Induction of placental maturation at induced parturiton in cows

• Project/Area Number: 16H05040
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Veterinary medical science
• Research Institution: Tokyo University of Agriculture
• Principal Investigator: HIRAYAMA Hiroki 東京農業大学, 生物産業学部, 教授 (60390861)
• Co-Investigator(Kenkyū-buntansha): 古山 敬祐 大阪府立大学, 生命環境科学研究科, 講師 (50611026)
• Project Period (FY): 2016-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000); Fiscal Year 2019: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2018: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2017: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2016: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
• Keywords: 牛 / 分娩 / 胎盤停滞 / ウシ / 分娩誘起 / 炎症 / 胎盤

Outline of Final Research Achievements

In this study, the administration of glucocorticoids induced the expression of genes involved in prostaglandin synthesis in placentomes at parturition. The expression of C-C chemokines was increased in placentomes at spontaneous parturition. C-C chemokines are responsible for the recruitment of the leukocytes to the site of inflammation. However, the administration of glucocorticoids did not influence the expression of C-C chemokines. These results suggest that further studies on administration methods of glucocorticoids are needed in order to reduce the incidence of retained fetal membrane after parturition.

Academic Significance and Societal Importance of the Research Achievements

繁殖牛の適正な分娩管理は、分娩時の事故による母体や子牛の損耗を防ぐとともに、分娩した個体の生殖機能回復を早めることで繁殖効率の向上につながる。本研究の成果は、分娩牛に発生する重要な疾患の一つである胎盤停滞の発生メカニズムの解明や分娩誘起技術の改良を通じて、牛の繁殖効率向上による乳肉など畜産物の安定的生産に寄与するものである。

Research Products

• [Journal Article] Expression of C–C motif chemokines and their receptors in bovine placentomes at spontaneous and induced parturition (2020)
  • Author(s): Hirayama, H., Sakumoto, R., Koyama, K., Yasuhara, T., Hasegawa, T., Inaba, R., Fujii, T., Naito, A., Moriyasu, S., & Kageyama, S.
  • Journal Title: Journal of Reproduction and Development Volume: 66 Issue: 1 Pages: 49-55
  • DOI: 10.1262/jrd.2019-113
  • NAID: 130007798074
  • ISSN: 0916-8818, 1348-4400
  • Peer Reviewed / Open Access
• [Journal Article] Enhanced glucocorticoid exposure facilitates the expression of genes involved in prostaglandin and estrogen syntheses in bovine placentomes at induced parturition. (2019)
  • Author(s): Yasuhara, T., Koyama, K., Sakumoto, R., Fujii, T., Naito, A., Moriyasu, S., Kageyama, S., & Hirayama, H.
  • Journal Title: Theriogenology Volume: 139 Pages: 1-7
  • DOI: 10.1016/j.theriogenology.2019.07.016
  • Peer Reviewed
• [Presentation] ウシ分娩時胎盤節における主要組織適合遺伝子複合体クラス1（BoLA-1）発現 (2018)
  • Author(s): 泰原大治・古山敬祐・作本亮介・小林祐子・平山博樹
  • Organizer: 第111回日本繁殖生物学会大会
• [Presentation] 乳牛のグルココルチコイドによる誘起分娩時胎盤節のプロスタグランジン合成酵素発現 (2018)
  • Author(s): 泰原大治・古山敬祐・作本亮介・平山博樹
  • Organizer: 日本畜産学会第124回大会
• [Presentation] グルココルチコイドによる誘起分娩がウシ胎盤節におけるプロスタグランジン合成酵素発現に及ぼす影響 (2017)
  • Author(s): 平山博樹・泰原大治・古山敬祐・作本亮介・藤井貴志・森安悟
  • Organizer: 日本畜産学会第122回大会
  • Place of Presentation: 神戸大学（神戸市）
  • Year and Date: 2017-03-28
• [Presentation] Expression of CC chemokines and their receptors in bovine placentome at spontaneous and induced parturition (2017)
  • Author(s): Hiroki Hirayama, Ryosuke Sakumoto, Keisuke Koyama, Taichi Yasuhara, Taito Hasegawa, Takashi Fujii, Satoru Moriyasu
  • Organizer: Fourth World Congress of Reproductive Biotechnology
  • Int'l Joint Research