| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2018: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
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| Outline of Final Research Achievements |
Mesenchymal progenitor cells are common origin of fibroblasts and adipocytes whose excessive increase impairs muscle function. In the present research project, we demonstrated that fibroblastic differentiation of mesenchymal progenitors is reversible. Furthermore, we found that senescent mesenchymal progenitors strongly suppress myogenesis. Finally, we generated CSPG4 deficient rats and their phenotype was examined.
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