Mesenchymal progenitor cells as a niche factor of muscle tissues.
| Project/Area Number |
16H05041
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Integrative animal science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Yamanouchi Keitaro 東京大学, 大学院農学生命科学研究科(農学部), 准教授 (70272440)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2018: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
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| Keywords | 間葉系前駆細胞 / 筋分化 / 脂肪細胞 / 線維芽細胞 / 筋衛星細胞 / 骨格筋 / 筋ジストロフィー / ラット / CSPG4 / 生理学 / プロテオグリカン / 心筋 / 分化 |
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| Outline of Final Research Achievements |
Mesenchymal progenitor cells are common origin of fibroblasts and adipocytes whose excessive increase impairs muscle function. In the present research project, we demonstrated that fibroblastic differentiation of mesenchymal progenitors is reversible. Furthermore, we found that senescent mesenchymal progenitors strongly suppress myogenesis. Finally, we generated CSPG4 deficient rats and their phenotype was examined.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究では、間葉系前駆細胞の分化が可逆的であることや、老化した間葉系前駆細胞が周囲の筋の正常な発達を抑制することを見出した。さらに、間葉系前駆細胞の分化制御にCSPG4分子が関わることを発見した。これらの知見はいずれも、間葉系前駆細胞を標的とすることで筋ジストロフィーなどの重篤な筋疾患の新たな解決法の開発に繋がる可能性を示すものである。
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Report
(4 results)
Research Products
(33 results)
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[Journal Article] Roles of chondroitin sulfate proteoglycan 4 in fibrogenic/adipogenic differentiation in skeletal muscle tissues.2016
Author(s)
Takeuchi S, Nakano S, Nakamura K, Ozoe A, Chien P, Yoshihara H, Hakuno F, Matsuwaki T, Saeki Y, Takahashi S, Yamanouchi K, Nishihara M
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Journal Title
Experimental Cell Research
Volume: 347
Issue: 2
Pages: 367-377
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Presentation] Identification of chondroitin sulfate proteoglycan 4 as a marker for mesenchymal progenitor cells and its possible involvement in adipogenic/fibrogenic differentiation.2016
Author(s)
Takeuchi S, Nakano SI, Nakamura K, Ozoe A, Chien P, Yoshihara H, Hakuno F, Matsuwaki T, Saeki Y, Takahashi SI, Yamanouchi K, Nishihara M
Organizer
FASEB summer research conference "Skeletal Muscle Satellite Cells and Regeneration"
Related Report
Int'l Joint Research
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