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Treatment strategy based on the pathophysiology of renal-multi-organ axis induced by pathogenic albumin

Research Project

Project/Area Number 16H05114
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Medical pharmacy
Research InstitutionKumamoto University

Principal Investigator

Watanabe Hiroshi  熊本大学, 大学院生命科学研究部(薬), 准教授 (70398220)

Co-Investigator(Kenkyū-buntansha) 小田切 優樹  崇城大学, 薬学部, 特任教授 (80120145)
丸山 徹  熊本大学, 薬学部, 教授 (90423657)
Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2019: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2018: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2017: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2016: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Keywordsアルブミン / 尿毒症物質 / 酸化ストレス / 筋萎縮 / 尿酸 / CYP3A / 脂肪酸代謝 / 腎病態 / 脂肪酸 / 酸化アルブミン / Elovl6 / 腎疾患 / バイカーカー / 尿毒素 / バイオマーカー / 二次性副甲状腺機能亢進症 / 副甲状腺ホルモン / ABCG2 / 薬学 / 腎ー多臓器連関 / 骨格筋 / 腎-多臓器連関
Outline of Final Research Achievements

We focused on the diversity of albumin molecules as a disease-progressing factor of the chronic kidney disease. We investigated 1) the molecular mechanism of skeletal muscle atrophy induced by uremic substances and 2) its therapeutic strategy, 3) the molecular mechanism of secondary hyperparathyroidism (SHPT)-induced hyperuricemia, and 4) the inhibition of CYP3A expression in SHPT, and 5) the molecular mechanism of renal tubular injury associated with renal fatty acid fluctuations, then found that indoxyl sulfate, parathyroid hormone and oxidized albumin were identified as negative humoral factors in chronic kidney disease. We also proposed a therapeutic target based on their molecular mechanism.

Academic Significance and Societal Importance of the Research Achievements

慢性腎臓病(CKD)の場合、死亡や要介護状態の原因となる心血管疾患(CVD)や筋力低下(サルコペニア)・骨萎縮を合併しやすいが、既存の治療方法ではその進行を抑制できず、新たな治療戦略の構築が希求されている。本申請課題は、悪玉となる液性因子の探索と、それを基軸とした新規CKD個別化診断・治療戦略の道を拓く循環型のトランスレーション研究である。本研究成果はCKDを基軸とした多臓器連関に対する早期診断・治療に繋がるため、臨床的、社会的意義と波及効果は非常に高く、医療経済的観点からも緊急性は高いと思われる。

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • Research Products

    (59 results)

All 2020 2019 2018 2017 2016 Other

All Journal Article (18 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 14 results,  Open Access: 7 results,  Acknowledgement Compliant: 4 results) Presentation (33 results) (of which Int'l Joint Research: 3 results,  Invited: 2 results) Book (6 results) Remarks (1 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] α1-acid glycoprotein attenuates adriamycin-induced nephropathy via CD163 expressing macrophages induction2020

    • Author(s)
      Fujimura R, Watanabe H, Nishida K, Fujiwara Y, Koga T, Bi J, Imafuku T, Kobayashi K, Komori H, Miyahisa M, Maeda H, Tanaka M, Matsushita K, Wada T, Fukagawa M, Maruyama .
    • Journal Title

      Kidney360

      Volume: in press

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Systemic and sustained thioredoxin analogue prevents acute kidney injury and its-associated distant organ damage in renal ischemia reperfusion injury mice2020

    • Author(s)
      Nishida K, Watanabe H, Miyahisa M, Hiramoto Y, Nosaki H, Fujimura R, Maeda H, Otagiri M, and Maruyama M
    • Journal Title

      Sci Rep.

      Volume: in press

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Sarcopenia in Chronic Kidney Disease: Factors, Mechanisms, and Therapeutic Interventions2019

    • Author(s)
      Watanabe H, Enoki Y, Maruyama T.
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 42 Issue: 9 Pages: 1437-1445

    • DOI

      10.1248/bpb.b19-00513

    • NAID

      130007700086

    • ISSN
      0918-6158, 1347-5215
    • Year and Date
      2019-09-01
    • Related Report
      2019 Annual Research Report
  • [Journal Article] Effect of Serum Parathyroid Hormone on Tacrolimus Therapy in Kidney Transplant Patients: A Possible Biomarker for a Tacrolimus Dosage Schedule2019

    • Author(s)
      Hirata K, Watanabe H, Toyoda M, Sugimoto R, Ikegami K, Imafuku T, Matsuzaka K, Ichimizu S, Maeda H, Uekihara S, Jingami S, Maruyama T.
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 42 Issue: 5 Pages: 786-791

    • DOI

      10.1248/bpb.b18-00976

    • NAID

      130007641447

    • ISSN
      0918-6158, 1347-5215
    • Year and Date
      2019-05-01
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cell-penetrating mechanism of intracellular targeting albumin: Contribution of macropinocytosis induction and endosomal escape.2019

    • Author(s)
      Ichimizu S, Watanabe H, Maeda H, Hamasaki K, Ikegami K, Chuang VTG, Kinoshita R, Nishida K, Shimizu T, Ishima Y, Ishida T, Seki T, Katsuki H, Futaki S, Otagiri M, Maruyama T
    • Journal Title

      J Control Release.

      Volume: S0168-3659 Pages: 30174-30177

    • DOI

      10.1016/j.jconrel.2020.03.022

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Effect of serum parathyroid hormone on tacrolimus therapy in kidney transplant patients:A possible biomarker for a tacrolimus dosage schedule2019

    • Author(s)
      Hirata K, Watanabe H, Toyoda M, Sugimoto R, Ikegami K, Imafuku T, Matsuzaka K, Ichimizu S, Maeda H, Uekihara S, Jingami S and Maruyama T
    • Journal Title

      Biol Pharm Bull

      Volume: in press

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A downstream molecule of 1,25-dihydroxyvitamin D3, alpha-1-acid glycoprotein, protects against mouse model of renal fibrosis2018

    • Author(s)
      Bi J, Watanabe H, Fujimura R, Nishida K, Nakamura R, Oshiro S, Imafuku T, Komori H, Miyahisa M, Tanaka M, Matsushita K, Maruyama T
    • Journal Title

      Sci Rep

      Volume: 26 Issue: 1 Pages: 17329-17329

    • DOI

      10.1038/s41598-018-35339-x

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Role of parathyroid hormone in regulating transporter and metabolizing enzyme function2018

    • Author(s)
      Watanabe H, Maruyama T
    • Journal Title

      Therapeutic Apheresis and Dialysis

      Volume: 22 Pages: 251-254

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 尿毒症物質2018

    • Author(s)
      渡邊博志、丸山徹
    • Journal Title

      透析患者の検査値の読み方 改訂第4版

      Volume: 4 Pages: 221-223

    • Related Report
      2018 Annual Research Report
  • [Journal Article] 尿毒症物質パラクレジル硫酸によるNADPH oxidase活性化を介した尿細管および血管障害作用2018

    • Author(s)
      渡邊博志
    • Journal Title

      腎とフリーラジカル 第13集

      Volume: 13 Pages: 64-66

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Potential therapeutic interventions for chronic kidney disease-associated sarcopenia via indoxyl sulfate-induced mitochondrial dysfunction2017

    • Author(s)
      Enoki Y, Watanabe H, Arake R, Fujimura R, Ishiodori K, Imafuku K, Nishida K, Sugimoto R, Nagao S, Miyamura S, Ishima Y, Tanaka M, Matsushita K, Komaba H, Fukagawa M, Otagiri M, Maruyama T
    • Journal Title

      J Cachexia Sarcopenia Muscle

      Volume: 8 Issue: 5 Pages: 735-747

    • DOI

      10.1002/jcsm.12202

    • NAID

      120006869527

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The down-regulation of ABCG2, a urate exporter, by parathyroid hormone enhances urate accumulation in secondary hyperparathyroidism2017

    • Author(s)
      Sugimoto R, Watanabe H, Ikegami K, Enoki Y, Imafuku T, Sakaguchi Y, Murata M, Nishida K, Miyamura M, Ishima Y, Tanaka M, Matsushita K, Komaba H, Fukagawa M, Otagiri M, Toru Maruyama
    • Journal Title

      Kidney Int

      Volume: 91 Issue: 3 Pages: 658-670

    • DOI

      10.1016/j.kint.2016.09.041

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Clinical Implications Associated With the Posttranslational Modification-Induced Functional Impairment of Albumin in Oxidative Stress-Related Diseases.2017

    • Author(s)
      Watanabe H, Imafuku T, Otagiri M, Maruyama T.
    • Journal Title

      J Pharm Sci.

      Volume: S0022-3549 Issue: 9 Pages: 18-25

    • DOI

      10.1016/j.xphs.2017.03.002

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Human serum albumin hydropersulfide is a potent reactive oxygen species scavenger in oxidative stress conditions such as chronic kidney disease2016

    • Author(s)
      Shibata A, Ishima Y, Ikeda M, Sato H, Imafuku T, Chuang VT, Ouchi Y, Abe T, Watanabe H, Ishida T, Otagiri M, Maruyama T
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 479 Issue: 3 Pages: 578-583

    • DOI

      10.1016/j.bbrc.2016.09.113

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Indoxyl sulfate potentiates skeletal muscle atrophy by inducing the oxidative stress-mediated expression of myostatin and atrogin-12016

    • Author(s)
      Enoki Y, Watanabe H, Arake R, Sugimoto R, Imafuku T, Tominaga Y, Ishima Y, Kotani S, Nakajima M, Tanaka M, Matsushita K, Fukagawa M, Otagiri M, Maruyama T
    • Journal Title

      Sci Rep

      Volume: 6 Issue: 1 Pages: 32084-32084

    • DOI

      10.1038/srep32084

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effect of a Ferric Citrate Formulation, a Phosphate Binder, on Oxidative Stress in Chronic Kidney Diseases-Mineral and Bone Disorder Patients Receiving Hemodialysis: A Pilot Study2016

    • Author(s)
      Tanaka M, Miyamura S, Imafuku T, Tominaga Y, Maeda H, Anraku M, Yamasaki K, Kadowaki D, Ishima Y, Watanabe H, Okuda T, Itoh K, Matsushita K, Fukagawa M, Otagiri M, Maruyama T
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 39 Issue: 6 Pages: 1000-1006

    • DOI

      10.1248/bpb.b15-01021

    • NAID

      130005155137

    • ISSN
      0918-6158, 1347-5215
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The clinical significance of plasma neopterin in heart failure with preserved left ventricular ejection fraction2016

    • Author(s)
      Yamamoto E, Hirata Y, Tokitsu T, Kusaka H, Tabata N, Tsujita K, Yamamuro M, Kaikita K, Watanabe H, Hokimoto S, Maruyama T, Ogawa H
    • Journal Title

      ESC Heart Failure

      Volume: 3 Pages: 53-59

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Comparison of Posttranslational Modification and the Functional Impairment of Human Serum Albumin in Commercial Preparations2016

    • Author(s)
      Miyamura S, Imafuku T, Anraku M, Taguchi K, Yamasaki K, Tominaga Y, Maeda H, Ishima Y, Watanabe H, Otagiri M, Maruyama T
    • Journal Title

      J Pharm Sci

      Volume: 105 Pages: 1043-1049

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] 腎虚血再灌流障害における急性相反応物質α1-酸性糖蛋白質の病態生理学的役割に関する検討2019

    • Author(s)
      平元 勇斗、渡邊 博志、西田 健人、ビー ジュン、藤村 留衣、前田 仁志、椋木 歩、竹尾 透、中潟 直己、深川 雅史、丸山 徹
    • Organizer
      第62回日本腎臓学会学術総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 合成レチノイン酸タミバロテンによる腎線維化抑制作用2019

    • Author(s)
      中村遼太、Bi Jing、渡邊博志、今福匡司、藤村留衣、大城俊、西田健人、丸山徹
    • Organizer
      第62回日本腎臓学会学術総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 酸化修飾アルブミンが誘発する腎組織中脂肪酸組成の変動と尿細管障害の分子機構2019

    • Author(s)
      今福匡司、渡邊博志、佐藤崇雄、田中元子、松下和孝、深川雅史、丸山徹
    • Organizer
      第62回日本腎臓学会学術総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] CKD誘発筋萎縮病態における蛋白質過酸化物AOPPsの関与2019

    • Author(s)
      加藤大雅、渡邊博志、今福匡司、田中元子、松下和孝、丸山徹
    • Organizer
      第62回日本腎臓学会学術総会2019
    • Related Report
      2019 Annual Research Report
  • [Presentation] 副甲状腺ホルモン関連蛋白質は癌病態においてCYP3A発現を抑制する2019

    • Author(s)
      松坂幸太朗、藤田一星、渡邊博志、杉本龍星、池上孝明、前田仁志、丸山徹
    • Organizer
      第4回日本臨床薬理学会九州・沖縄地方会
    • Related Report
      2019 Annual Research Report
  • [Presentation] CKD誘発骨格筋萎縮における蛋白質過酸化物AOPPsの役割2019

    • Author(s)
      渡邊博志、加藤大雅、今福匡司、田中元子、松下和孝、丸山徹
    • Organizer
      Reasearch PlaNet 2019
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 尿毒症物質が誘発する脂肪組織炎症の分子機構と治療戦略2019

    • Author(s)
      田中翔馬、渡邊博志、今福匡司、榎木裕紀、前田仁志、丸山徹
    • Organizer
      第43回西日本薬剤学研究会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Long-acting thioredoxin prevents AKI to CKD transition via its anti-oxidative and anti-inflammatory action2019

    • Author(s)
      Hiroshi Watanabe, Kento Nishida, Rui Fujimura, Toru Maruyama
    • Organizer
      ASN kidney week2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Alpha-1 acid glycoprotein ameliorates hemolysis-induced renal oxidative stress via accelerating plasma free hemoglobin clearance through CD163 induction2019

    • Author(s)
      Rui Fujimura, Hiroshi Watanabe, Kento Nishida, Jing Bi, Toru Maruyama
    • Organizer
      ASN kidney week2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 尿毒症物質により誘発される脂肪組織炎症-腎障害連関の分子機構解明2019

    • Author(s)
      田中 翔馬、渡邊 博志、今福 匡司、榎木 裕紀、前田 仁志、丸山 徹
    • Organizer
      第36回日本薬学会九州支部大会2019
    • Related Report
      2019 Annual Research Report
  • [Presentation] CKDとサルコペニア~要因、分子機構、治療介入~2019

    • Author(s)
      渡邊博志
    • Organizer
      第13回日本腎臓病薬物療法学会学術集会・総会2019
    • Related Report
      2019 Annual Research Report
  • [Presentation] 副甲状腺ホルモンによる肝臓及び小腸CYP3A発現抑制は腎移植患者における初回タクロリムス投与量の規定因子となる2019

    • Author(s)
      渡邊博志、平田憲史郎、杉本龍星、池上孝明、前田仁志、陣上祥子、深川雅史、丸山 徹
    • Organizer
      第2回日本Uremic Toxin研究会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 酸化ストレスが誘発する腎組織中脂肪酸の質的変動と腎病態との関連2019

    • Author(s)
      今福匡司、渡邊博志、佐藤崇雄、田中元子、松下和孝、丸山徹
    • Organizer
      第60回日本脂質生化学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 腎組織の脂肪酸代謝異常を基軸とした新規腎病態形成機序の解明2018

    • Author(s)
      今福匡司、渡邊博志、佐藤祟雄、田中元子、松下和孝、深川雅史、丸山徹
    • Organizer
      第61回日本腎臓学会学術総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 副甲状腺ホルモンによる肝臓及び小腸CYP3A発現抑制の分子機構解明と 腎移植患者におけるタクロリムス血中濃度との関連2018

    • Author(s)
      池上孝明、渡邊博志、杉本龍星、前田仁志、丸山徹
    • Organizer
      九重セミナー 第42回西日本薬剤学研究会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 腎組織中脂肪酸の質的変動から見出した新規腎障害メカニズム2018

    • Author(s)
      今福匡司、渡邊博志、佐藤 崇雄、田中元子、松下和孝、丸山 徹
    • Organizer
      第17回次世代を担う若手ファーマ・バイオフォーラム2018
    • Related Report
      2018 Annual Research Report
  • [Presentation] Parathyroid hormone-related protein secreted from cancer tissues contributes to the down-regulation of CYP3A2018

    • Author(s)
      Ikegami K, Watanabe H, Sugimoto R, Maeda H, Maruyama T
    • Organizer
      日本薬物動態学会第33回年会/MDO国際合同学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 肝腎および腸腎連関における副甲状腺ホルモンの関与と腎外クリアランス変動の分子機構2018

    • Author(s)
      渡邊博志、杉本龍星、池上孝明、平田憲史郎、陣上祥子、田中元子、深川雅史、丸山徹
    • Organizer
      第40回生体膜と薬物の相互作用シンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] 尿毒素誘発骨格筋萎縮の分子機構を基盤した既存薬による治療戦略(口頭発表)2017

    • Author(s)
      渡邊博志、榎木裕紀、田中元子、松下和孝、駒場大峰、深川雅史、丸山徹
    • Organizer
      第1回日本CKD-MBD研究会学術集会・総会
    • Place of Presentation
      東京:コクヨホール
    • Year and Date
      2017-03-04
    • Related Report
      2016 Annual Research Report
  • [Presentation] 慢性腎臓病が誘発する骨格筋萎縮における尿毒素の関与とその分子機構(口頭発表)2017

    • Author(s)
      丸山 徹、渡邊 博志、榎木 裕紀、荒毛 里歩、田中 元子、松下 和孝、深川 雅史
    • Organizer
      第1回日本Uremic Toxin研究会学術集会
    • Place of Presentation
      東京:ベルサール八重洲
    • Year and Date
      2017-02-18
    • Related Report
      2016 Annual Research Report
  • [Presentation] 副甲状腺ホルモンはcAMP/PI3K/PKC/PKA/NF-κBシグナル経路を介してシトクロームP450 3Aの発現低下に寄与する2017

    • Author(s)
      池上孝明、渡邊博志、杉本龍星、平田憲史郎、陣上祥子、田中元子、深川雅史、小田切優樹、丸山徹
    • Organizer
      日本薬物動態学会第32回年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Parathyroid hormone contributes to the down-regulation of cytochrome P450 3A through cAMP/PI3K/Akt signaling pathway in secondary hyperparathyroidism2017

    • Author(s)
      Hiroshi Watanabe, Ryusei Sugimoto, Masafumi Fukagawa and Toru Maruyama
    • Organizer
      Kidney Week-ASN 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 腎機能低下に伴う薬物動態の臨床的意義~副甲状腺ホルモンによる新たな制御機構~2017

    • Author(s)
      渡邊博志、田中元子、深川雅史、丸山徹
    • Organizer
      医療薬学フォーラム2017 第25回クリニカルファーマシーシンポジウム
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 副甲状腺ホルモンによるABCG2の発現抑制を介した尿酸蓄積機構2017

    • Author(s)
      渡邊博志、杉本龍星、池上孝明、田中元子、深川雅史、小田切優樹、丸山徹
    • Organizer
      日本薬剤学会 第32回年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 酸化ストレス早期発見に向けた血清パースルフィド定量の有用性評価(口頭発表) *優秀発表賞2016

    • Author(s)
      池田 真由美、異島 優、渡邉 博志、石田 竜弘、小田切 優樹、丸山 徹
    • Organizer
      第33回日本薬学会九州支部大会
    • Place of Presentation
      鹿児島大学 群元キャンパス
    • Year and Date
      2016-12-03
    • Related Report
      2016 Annual Research Report
  • [Presentation] 新規酸化ストレス早期発見に向けた血清パースルフィド定量の有用性評価(口頭発表)2016

    • Author(s)
      池田真由美、異島 優、渡邊博志、石田竜弘、小田切優樹、丸山 徹
    • Organizer
      第38回生体膜と薬物の相互作用シンポジウム
    • Place of Presentation
      名古屋市立大学大学院薬学研究科・薬学部
    • Year and Date
      2016-11-17
    • Related Report
      2016 Annual Research Report
  • [Presentation] Downregulation of ABCG2, a Urate Exporter, by Parathyroid Hormone Enhances Urate Accumulation in Secondary Hyperparathyroidism(ポスター発表)2016

    • Author(s)
      Hiroshi Watanabe, Ryusei Sugimoto, Motoko Tanaka, Hirotaka Komaba, Masafumi Fukagawa and Toru Maruyama
    • Organizer
      第49回米国腎臓学会議 Kidney Week-ASN
    • Place of Presentation
      USA:Chicago McCormick Place
    • Year and Date
      2016-11-17
    • Related Report
      2016 Annual Research Report
  • [Presentation] 慢性腎臓病が誘発する骨格筋萎縮における尿毒素の関与とその分子機構(口頭発表)*最優秀演題賞2016

    • Author(s)
      渡邊博志、榎木裕紀、荒毛里歩、田中元子、松下和孝、深川雅史、丸山徹
    • Organizer
      第3回日本サルコペニア・フレイル研究会研究発表会
    • Place of Presentation
      名古屋:今池ガスビル
    • Year and Date
      2016-11-06
    • Related Report
      2016 Annual Research Report
  • [Presentation] Molecular mechanism of uremic toxin induced-skeletal muscle atrophy in chronic kidney disease(ポスター発表)2016

    • Author(s)
      Hiroshi Watanabe, Yuki Enoki, Riho Arake, Motoko Tanaka, Kazutaka Matsushita, Masafumi Fukagawa and Toru Maruyama
    • Organizer
      The 2nd Asian Conference for Frailty and Sarcopenia (ACFS)
    • Place of Presentation
      名古屋:今池ガスビル
    • Year and Date
      2016-11-04
    • Related Report
      2016 Annual Research Report
  • [Presentation] 慢性腎臓病が誘発する骨格筋萎縮に対するAST-120の有効性評価2016

    • Author(s)
      渡邊 博志、榎木 裕紀、荒毛 里歩、田中 元子、深川 雅史、小田切 優樹、丸山 徹
    • Organizer
      第31回日本薬物動態学会
    • Place of Presentation
      長野:キッセイ文化ホール 松本市総合体育館
    • Year and Date
      2016-10-13
    • Related Report
      2016 Annual Research Report
  • [Presentation] 副甲状腺ホルモンは尿酸排泄トランスポーターの発現抑制を介して尿酸の蓄積を促進する(口頭発表)2016

    • Author(s)
      杉本 龍星、渡邊 博志、異島 優、田中 元子、松下 和孝、駒場 大峰、深川 雅史、丸山 徹
    • Organizer
      第59回日本腎臓学会学術総会
    • Place of Presentation
      神奈川 : パシフィコ横浜、会議センター
    • Year and Date
      2016-06-17
    • Related Report
      2016 Annual Research Report
  • [Presentation] CKD誘発骨格筋紹介に対するAST-120の有効性評価(口頭発表)2016

    • Author(s)
      荒毛 里歩、榎木 裕紀、渡邊 博志、異島 優、田中 元子、松下 和孝、深川 雅史、小田切 優樹、丸山 徹
    • Organizer
      第59回日本腎臓学会学術総会
    • Place of Presentation
      神奈川 : パシフィコ横浜、会議センター
    • Year and Date
      2016-06-17
    • Related Report
      2016 Annual Research Report
  • [Presentation] 質量分析によるアルブミンの翻訳後修飾解析を基軸とした糖尿病患者の酸化ストレス評価(ポスター発表)2016

    • Author(s)
      今福 匡司、 宮村 重幸、異島 優、渡邊 博志、吉田 陽、陣内 秀昭、丸山 徹
    • Organizer
      第59回日本糖尿病学会年次学術集会
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2016-05-19
    • Related Report
      2016 Annual Research Report
  • [Book] Molecular mechanism of muscle wasting in CKD. Recent advances of sarcopenia and frailty in CKD2020

    • Author(s)
      Watanabe H, Enoki Y, Maruyama T
    • Total Pages
      20
    • Publisher
      Springer
    • Related Report
      2019 Annual Research Report
  • [Book] 副甲状腺ホルモンによる高尿酸血症発症のメカニズム2017

    • Author(s)
      渡邊博志、丸山徹
    • Total Pages
      2
    • Publisher
      医歯薬出版株式会社
    • Related Report
      2017 Annual Research Report
  • [Book] 副甲状腺ホルモンの新しい標的臓器とその作用2017

    • Author(s)
      丸山徹、渡邊博志、田中元子
    • Total Pages
      6
    • Publisher
      日本メディカルセンター
    • Related Report
      2017 Annual Research Report
  • [Book] Albumin as a biomarker. Human serum albumin: Pharmaceutical and medical applications, edited by Masaki Otagiri2016

    • Author(s)
      Hiroshi Watanabe, Toru Maruyama
    • Total Pages
      19
    • Publisher
      Springer
    • Related Report
      2016 Annual Research Report
  • [Book] タンパク結合率の臨床的な意義を教えて下さい。2016

    • Author(s)
      渡邊博志、丸山徹
    • Total Pages
      5
    • Publisher
      月刊薬事
    • Related Report
      2016 Annual Research Report
  • [Book] CKD-MBDにおけるリン吸着薬の進歩と治療選択~リンと鉄の関連を含めて~ 最新透析医療 先端技術との融合2016

    • Author(s)
      田中元子、伊藤和子、奥田智子、今福匡史、渡邊博志、丸山徹、小泉賢洋、角田隆俊、深川雅史
    • Total Pages
      3
    • Publisher
      医薬ジャーナル社
    • Related Report
      2016 Annual Research Report
  • [Remarks] 薬剤学分野HP

    • URL

      http://www.pharm.kumamoto-u.ac.jp/Labs/Yakuzai/

    • Related Report
      2019 Annual Research Report
  • [Patent(Industrial Property Rights)] α1-酸性糖タンパク質の血中濃度上昇をメカニズムとした慢性腎臓病治療薬2017

    • Inventor(s)
      丸山徹、渡邊博志、異島優、藤村留依、小田切優樹
    • Industrial Property Rights Holder
      丸山徹、渡邊博志、異島優、藤村留依、小田切優樹
    • Industrial Property Rights Type
      特許
    • Filing Date
      2017-03-25
    • Related Report
      2016 Annual Research Report

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Published: 2016-04-21   Modified: 2021-02-19  

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