Significance of lipid metabolism in glial cell function: association with psychiatiric diseases
| Project/Area Number |
16H05116
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General anatomy (including histology/embryology)
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| Research Institution | Tohoku University |
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Principal Investigator |
Owada Yuji 東北大学, 医学系研究科, 教授 (20292211)
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| Co-Investigator(Kenkyū-buntansha) |
香川 慶輝 東北大学, 医学系研究科, 助教 (30728887)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2018: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2016: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
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| Keywords | グリア細胞 / 遺伝子欠損マウス / エピゲノム / 長鎖脂肪酸 / GABA / アストロサイト / 脱髄モデル / オリゴデンドロサイト前駆細胞 / ノックアウトマウス / 脂肪酸結合蛋白質 / 視床下部 / 脂質 / リポカイン / 遺伝子ノックアウトマウス / 脂肪酸結合タンパク質 / グリア / 睡眠 / オリゴデンドロサイト / 脂肪酸 |
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| Outline of Final Research Achievements |
In this study, we aimed to clarify the molecular basis how the cellular lipid environment affects the function of neural cells including neurons and glia. In addition, we also explored whether alteration of brain lipid metabolism is associated with the normal or pathological brain functions. We mainly revealed that fatty acid binding protein (FABP) in the cortical neurons is involved in the expression of behaviors through its epigenetic regulation of neurotransmitter synthesis, and that FABP in glia is important in the control of glial lipid metabolism and it is also involved in the glial proliferation and neuronal plasticity control through epigenetic regulation of lipid metabolism.
These results are expected to contribute to research and development in the fields of psychiatry and health sciences.
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| Academic Significance and Societal Importance of the Research Achievements |
脂質の摂取障害が、学習や情動などに影響を及ぼすことは栄養学的に古くから知られている。しかしながら、脂質摂取の異常（あるいは脂質代謝関連分子の異常）と神経活動の関連性については、未だ不明な点が多い。本研究成果は、脳機能を正常に保つには、神経系細胞において脂質を適切に調節・維持することが重要であることを示している。言い換えれば、その調節が上手くいかない場合には、精神疾患をはじめとする脳疾患につながることを意味している。
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Report
(4 results)
Research Products
(34 results)
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[Journal Article] Infection Programs Sustained Lymphoid Stromal Cell Responses and Shapes Lymph Node Remodeling upon Secondary Challenge.2017
Author(s)
Gregory JL, Walter A, Alexandre YO, Hor JL, Liu R, Ma JZ, Devi S, Tokuda N, Owada Y, Mackay LK, Smyth GK, Heath WR, Mueller SN.
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Journal Title
Cell Rep
Volume: 18
Issue: 2
Pages: 406-418
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Microglia-derived neuregulin expression in psychiatric disorders.2017
Author(s)
Ikawa D, Makinodan M, Iwata K, Ohgidani M, Kato TA, Yamashita Y, Yamamuro K, Kimoto S, Toritsuka M, Yamauchi T, Fukami SI, Yoshino H, Okumura K, Tanaka T, Wanaka A, Owada Y, Tsujii M, Sugiyama T, Tsuchiya K, Mori N, Hashimoto R, Matsuzaki H, Kanba S, Kishimoto T.
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Journal Title
Brain Behav Immun.
Volume: 61
Pages: 375-385
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Characterization of Fatty Acid Binding Protein 7 (FABP7) in the Murine Retina.2016
Author(s)
Su X, Tan QS, Parikh BH, Tan A, Mehta MN, Sia Wey Y, Tun SB, Li LJ, Han XY, Wong TY, Hunziker W, Luu CD, Owada Y, Barathi VA, Zhang SS, Chaurasia SS.
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Journal Title
Invest Ophthalmol Vis Sci
Volume: 57
Issue: 7
Pages: 3397-408
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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