| Project/Area Number |
16H05145
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General medical chemistry
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| Research Institution | Kansai Medical University |
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Principal Investigator |
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| Research Collaborator |
AKAMA Tomoya
KAGESHIMA Masami
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2018: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2016: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
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| Keywords | 細胞外マトリックス / 弾性線維 / 老化 / 再生 / 細胞・組織 / 再生医学 |
|---|
| Outline of Final Research Achievements |
Tissue elasticity in organs such as skin, arteries, and lungs is conferred by an extracellular matrix named elastic fiber. Aging-associated deterioration of elastic fibers causes loose skin, arteriosclerosis, and emphysema, while elastic fibers do not regenerate in adult tissues. In this study, we analyzed molecular function of Fibulin-4 and 5, and LTBP-2 and 4, which we have identified as elastogenic proteins, and obtained findings that may lead to elastic fiber regenerative therapy.
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| Academic Significance and Societal Importance of the Research Achievements |
老化に伴って私達の体は伸縮性を失ってゆく。皮膚はたるみ、動脈は硬くなり、肺が縮みにくくなって呼吸機能が低下する。これらは、伸縮性を担う弾性線維が劣化・断裂していくことに起因する。弾性線維のターンオーバーは極めて遅く、成長期を過ぎると弾性線維は再生されないとされるが、その理由はわかっていない。本研究は、弾性線維がどのようにして作られるのか、そのしくみの一端を明らかにしたものであり、弾性線維再生に必要な基盤的知識となるものである。
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