• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Research on regulatory T cell-therapy without inducing cancer and severe infections-the safe and effective immunosuppression from Japan

Research Project

Project/Area Number 16H05177
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Experimental pathology
Research InstitutionNagoya City University

Principal Investigator

Yamazaki Sayuri  名古屋市立大学, 大学院医学研究科, 教授 (70567255)

Co-Investigator(Kenkyū-buntansha) 小田中 瑞夕  名古屋市立大学, 大学院医学研究科, 研究員 (00510281)
大倉 永也  大阪大学, 医学系研究科, 特任教授(常勤) (20300949)
今井 優樹  名古屋市立大学, 大学院医学研究科, 講師 (30440936)
Research Collaborator MORITA Akimichi  名古屋市立大学, 大学院医学研究科, 教授 (30264732)
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2018: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2017: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2016: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
Keywords制御性T細胞 / 樹状細胞 / 抗原特異性 / 抗原提示 / 抗原特異的 / 免疫
Outline of Final Research Achievements

We showed that antigen presentation by dendritic cells expand antigen-specific regulatory T cells and that dendritic cell-expanded regulatory T cells suppress autoimmunity and graft-versus host disease in a specific way using mice. Based on these our former reports, we performed experiments to control antigen specificity of regulatory T cells using murine and human dendritic cells. In this project in the past three years, we were able to report several findings including a dendritic subset to expand regulatory T cells specifically and its gene expressions.

Academic Significance and Societal Importance of the Research Achievements

本研究では、制御性T細胞を特異的に増殖誘導する樹状細胞のサブセットを見出し、遺伝子発現解析にも成功するなどの成果をあげることができた。これらの成果は、3つの国際学会で口演に選出され、学術的にも注目されている。重篤感染症や発癌の誘因とならない安全な免疫抑制療法の開発が、増加する自己免疫疾患、移植、アレルギーの治療に世界的に求められている。本研究の成果を今後さらに発展させることで、将来、日本発の安全で有効な制御性T細胞療法の開発に貢献も期待され、社会的にも意義が大きい。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • Research Products

    (33 results)

All 2019 2018 2017 2016 Other

All Int'l Joint Research (6 results) Journal Article (8 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 5 results,  Open Access: 4 results) Presentation (16 results) (of which Int'l Joint Research: 8 results,  Invited: 3 results) Remarks (3 results)

  • [Int'l Joint Research] Guido Ferlazzo/University of Messina(イタリア)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] Su I-hsin/Nanyang Technological University(シンガポール)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] Milael Karlsson/Karolinska Institute(スウェーデン)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] Michel Nussenzweig/Rockefeller University(米国)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] Dieter Riethmacher/Nazarbayev University(カザフスタン)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] NAZARBAYEV UNIVERSITY(カザフスタン)

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Hyperglycemia is associated with psoriatic inflammation in both humans and mice2019

    • Author(s)
      Ikumi K, Odanaka M, Shime H, Imai M, Osaga S, Taguchi O, Nishida E, Hemmi H, Kaisho T, Morita A, Yamazaki S
    • Journal Title

      Journal of Investigative Dermatology

      Volume: 印刷中 Issue: 6 Pages: 1329-1338

    • DOI

      10.1016/j.jid.2019.01.029

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Regulatory T cells expressing abundant CTLA-4 on the cell surface with a proliferative gene profile are key features of human head and neck cancer.2019

    • Author(s)
      Matoba T, Imai M, Ohkura N, Kawakita D, Ijichi K, Toyama T, Morita A, Murakami S, Sakaguchi S, Yamazaki S.
    • Journal Title

      International Journal of Cancer

      Volume: 144(11) Issue: 11 Pages: 2811-2822

    • DOI

      10.1002/ijc.32024

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 皮膚の樹状細胞と制御性T細胞のクロストークによる免疫制御2019

    • Author(s)
      山崎小百合、森田明理
    • Journal Title

      医学の歩み

      Volume: 268 Pages: 1165-1169

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Ezh2 Controls Skin Tolerance through Distinct Mechanisms in Different Subsets of Skin Dendritic Cells2018

    • Author(s)
      Loh Jia Tong、Lim Thomas Jun Feng、Ikumi Kyoko、Matoba Takuma、Janela Baptiste、Gunawan Merry、Toyama Tatsuya、Bunjamin Maegan、Ng Lai Guan、Poidinger Michael、Morita Akimichi、Ginhoux Florent、Yamazaki Sayuri、Lam Kong-Peng、Su I-hsin
    • Journal Title

      iScience

      Volume: 10 Pages: 23-39

    • DOI

      10.1016/j.isci.2018.11.019

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] TLRアゴニストを用いた抗癌免疫アジュバント療法2018

    • Author(s)
      志馬寛明、松本美佐子、山崎小百合、瀬谷司
    • Journal Title

      Thrombosis Medicine

      Volume: 8 Pages: 97-104

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
  • [Journal Article] Ultraviolet B?Induced Maturation of CD11b-Type Langerin?Dendritic Cells Controls the Expansion of Foxp3+Regulatory T Cells in the Skin2017

    • Author(s)
      Yamazaki Sayuri、Odanaka Mizuyu、Nishioka Akiko、Kasuya Saori、Shime Hiroaki、Hemmi Hiroaki、Imai Masaki、Riethmacher Dieter、Kaisho Tsuneyasu、Ohkura Naganari、Sakaguchi Shimon、Morita Akimichi
    • Journal Title

      The Journal of Immunology

      Volume: 200 Issue: 1 Pages: 119-129

    • DOI

      10.4049/jimmunol.1701056

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Bath-PUVA therapy improves impaired resting regulatory T cells and increases activated regulatory T cells in psoriasis2017

    • Author(s)
      Ryoji Kubo, Shinnosuke Muramatsu, Yoko Sagawa, Chiyo Saito, Saori Kasuya, Akiko Nishioka, Emi Nishida, Sayuri Yamazaki, Akimichi Morita
    • Journal Title

      Journal of Dermatological Science

      Volume: 86 Issue: 1 Pages: 46-53

    • DOI

      10.1016/j.jdermsci.2017.01.001

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] 制御性T細胞の恒常性と皮膚2016

    • Author(s)
      山崎小百合, 森田明理
    • Journal Title

      臨床皮膚科臨時増刊号

      Volume: 5 Pages: 39-41

    • Related Report
      2016 Annual Research Report
  • [Presentation] Skin dendritic cells expressing a unique set of genes associated with immunological tolerance are specialized to expand thymus-derived Foxp3+ regulatory T cells upon ultraviolet B exposure2019

    • Author(s)
      Yamazaki S, Odanaka M, Shime H, Imai M, Hemmi H, Kaisho T, Ohkura N, Sakaguchi S, Morita A.
    • Organizer
      Japan-Singapore International Skin Conference 2019
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 頭頸部癌における制御性T細胞の新たな特徴2019

    • Author(s)
      的場拓磨、今井優樹、大倉永也、川北大介、伊地知圭、遠山竜也、森田明理、村上信五、坂口志文、山崎小百合
    • Organizer
      第37回日本耳鼻咽喉科免疫アレルギー学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Foxp3+ regulatory T cells are expanded by ultraviolet B-exposed PD-L1+ skin dendritic cell expressing a unique set of genes in a CSF1-independent manner.2018

    • Author(s)
      Yamazaki S, Odanaka M, Nishioka A, Kasuya S, Shime H, Hemmi H, Imai M, Riethmacher D, Kaisho T, Ohkura N, Sakaguchi S, Morita A.
    • Organizer
      International Investigative Dermatology 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 紫外線で誘導される樹状細胞と制御性T細胞のクロストークによる免疫制御2018

    • Author(s)
      山崎小百合
    • Organizer
      第69回日本皮膚科学会中部支部学術大会特別講演
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 樹状細胞と制御性T細胞―二つのコントローラーによる免疫制御2018

    • Author(s)
      山崎小百合
    • Organizer
      第28回日本樹状細胞研究会 シンポジウム
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Dendritic cells expressing a unique set of genes associated with immunological tolerance are specialized to expand thymus-derived Foxp3+ regulatory T cells in the ultraviolet B-exposed skin2018

    • Author(s)
      Sayuri Yamazaki, Mizuyu Odanaka, Hiroaki Shime, Masaki Imai, Akiko Nishioka, Hiroaki Hemmi, Tsuneyasu Kaisho, Naganari Ohkura, Shimon Sakaguchi, Akimichi Morita
    • Organizer
      第47回日本免疫学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Hyperglycemia is associated with psoriatic inflammation in both humans and mice2018

    • Author(s)
      Mizuyu Odanaka, Kyoko Ikumi, Hiroaki Shime, Masaki Imai, Osamu Taguchi, Hiroaki Hemmi, Tsuneyasu Kaisho, Akimichi Morita, Sayuri Yamazaki
    • Organizer
      第47回日本免疫学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] A New Feature of Regulatory T Cells in Human Head and Neck Cancer2018

    • Author(s)
      Takuma Matoba, Masaki Imai, Naganari Ohkura, Daisuke Kawakita, Kei Ijichi, Tatsuya Toyama, Akimichi Morita, Shingo Murakami, Shimon Sakaguchi, Sayuri Yamazaki
    • Organizer
      第47回日本免疫学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Successful treatment of psoriatic inflammation restores hyperglycemia2018

    • Author(s)
      Kyoko Ikumi, Mizuyu Odanaka, Hiroaki Shime, Masaki Imai, Osamu Taguchi, Hiroaki Hemmi, Tsuneyasu Kaisho, Sayuri Yamazaki, Akimichi Morita
    • Organizer
      International Investigative Dermatology 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The critical role of dendritic cell subset in expanding Foxp3+ regulatory T cells in the murine skin after ultraviolet B exposure2017

    • Author(s)
      Yamazaki, S., Nishioka, A., Kasuya, S., Odanaka, M., Hemmi, H., Imai, M., Riethmacher, D., Kaisho, T., Ohkura, N., Sakaguchi, S., Morita, A
    • Organizer
      LC2017 15th International Workshop on Langerhans Cells. NewYork, USA
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Does Juzen-Taiho-Tohave immunosuppressive effect?2016

    • Author(s)
      Ken Kanno, Mizuyu Odanaka, Masaki Imai, Akiko Nishioka, Saori Kasuya, Mitsuhiko Nose, Hiroaki Henmi, Tsuneyasu Kaisho, Akimichi Morita, Sayuri Yamazaki
    • Organizer
      第45回日本免疫学会学術集会
    • Place of Presentation
      沖縄コンベンションセンター(沖縄県、宜野湾市)
    • Year and Date
      2016-12-05
    • Related Report
      2016 Annual Research Report
  • [Presentation] The complement anaphylatoxin C5ades Arg still induce the acute inflammatory responce2016

    • Author(s)
      Masaki IMAI, Mizuyu ODANAKA, Shoryu TAKAYAMA,Rieko Ohta, Sayuri YAMAZAKI
    • Organizer
      Cold Spring Harbor Conference Asia
    • Place of Presentation
      Awaji(Japan)
    • Year and Date
      2016-10-03
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Ultraviolet B exposure expands skin-homing receptor+ Foxp3+CD4+ regulatory T cells in the skin2016

    • Author(s)
      Mizuyu Odanaka, Sayuri Yamazaki, Akiko Nishioka, Saori Kasuya, Osamu Taguchi, Masaki Imai, Akimichi Morita
    • Organizer
      Cold Spring Harbor Conference Asia
    • Place of Presentation
      Awaji(Japan)
    • Year and Date
      2016-10-03
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Does Juzen-Taiho-To show therapeutic effect in Imiquimod-induced psoriatic mice?2016

    • Author(s)
      Ken Kanno, Masaki Imai, Mizuyu Odanaka, Akiko Nishioka, Saori Kasuya, Mitsuhiko Nose, Hiroaki Henmi, Tsuneyasu Kaisho, Akimichi Morita, Sayuri Yamazaki
    • Organizer
      Cold Spring Harbor Conference Asia
    • Place of Presentation
      Awaji(Japan)
    • Year and Date
      2016-10-03
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 樹状細胞と制御性T細胞を利用した 免疫制御と治療2016

    • Author(s)
      山崎小百合
    • Organizer
      愛知医科大学 特別講演
    • Place of Presentation
      愛知医科大学(愛知県、長久手市)
    • Year and Date
      2016-10-03
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Ultraviolet B Expands Skin-Homing Thymus-derived Foxp3+ CD4+ Regulatory T Cells2016

    • Author(s)
      Sayuri Yamazaki, Mizuyu Odanaka, Akiko Nishioka, Saori Kasuya,Masaki Imai, Osamu Taguchi, Akimichi Morita
    • Organizer
      Cold Spring Harbor Conference Gene Expression& Signaling in the Immune System
    • Place of Presentation
      NewYork(U.S.A)
    • Year and Date
      2016-04-27
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Remarks] 名古屋市立大学大学院医学研究科免疫学教室

    • URL

      https://www.nagoya-cu.ac.jp/med/labo/immune/index.html

    • Related Report
      2018 Annual Research Report
  • [Remarks] 名古屋市立大学大学院医学研究科免疫学分野

    • URL

      http://www.med.nagoya-cu.ac.jp/immunol.dir/index.html

    • Related Report
      2017 Annual Research Report
  • [Remarks] 名古屋市立大学大学院医学研究科免疫学

    • URL

      http://www.med.nagoya-cu.ac.jp/immunol.dir/index.html

    • Related Report
      2016 Annual Research Report

URL: 

Published: 2016-04-21   Modified: 2020-03-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi