Research on regulatory T cell-therapy without inducing cancer and severe infections-the safe and effective immunosuppression from Japan
| Project/Area Number |
16H05177
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Experimental pathology
|
|---|
| Research Institution | Nagoya City University |
|---|
Principal Investigator |
Yamazaki Sayuri 名古屋市立大学, 大学院医学研究科, 教授 (70567255)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
小田中 瑞夕 名古屋市立大学, 大学院医学研究科, 研究員 (00510281)
大倉 永也 大阪大学, 医学系研究科, 特任教授(常勤) (20300949)
今井 優樹 名古屋市立大学, 大学院医学研究科, 講師 (30440936)
|
|---|
| Research Collaborator |
MORITA Akimichi 名古屋市立大学, 大学院医学研究科, 教授 (30264732)
|
|---|
| Project Period (FY) |
2016-04-01 – 2019-03-31
|
| Project Status |
Completed (Fiscal Year 2018)
|
| Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2018: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2017: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2016: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
|
|---|
| Keywords | 制御性T細胞 / 樹状細胞 / 抗原特異性 / 抗原提示 / 抗原特異的 / 免疫 |
|---|
| Outline of Final Research Achievements |
We showed that antigen presentation by dendritic cells expand antigen-specific regulatory T cells and that dendritic cell-expanded regulatory T cells suppress autoimmunity and graft-versus host disease in a specific way using mice. Based on these our former reports, we performed experiments to control antigen specificity of regulatory T cells using murine and human dendritic cells. In this project in the past three years, we were able to report several findings including a dendritic subset to expand regulatory T cells specifically and its gene expressions.
|
| Academic Significance and Societal Importance of the Research Achievements |
本研究では、制御性T細胞を特異的に増殖誘導する樹状細胞のサブセットを見出し、遺伝子発現解析にも成功するなどの成果をあげることができた。これらの成果は、3つの国際学会で口演に選出され、学術的にも注目されている。重篤感染症や発癌の誘因とならない安全な免疫抑制療法の開発が、増加する自己免疫疾患、移植、アレルギーの治療に世界的に求められている。本研究の成果を今後さらに発展させることで、将来、日本発の安全で有効な制御性T細胞療法の開発に貢献も期待され、社会的にも意義が大きい。
|
Report
(4 results)
Research Products
(33 results)
-
-
-
-
-
-
-
[Journal Article] Hyperglycemia is associated with psoriatic inflammation in both humans and mice2019
Author(s)
Ikumi K, Odanaka M, Shime H, Imai M, Osaga S, Taguchi O, Nishida E, Hemmi H, Kaisho T, Morita A, Yamazaki S
-
Journal Title
Journal of Investigative Dermatology
Volume: 印刷中
Issue: 6
Pages: 1329-1338
DOI
Related Report
Peer Reviewed / Open Access
-
-
-
-
-
-
-
-
-
-
[Presentation] Foxp3+ regulatory T cells are expanded by ultraviolet B-exposed PD-L1+ skin dendritic cell expressing a unique set of genes in a CSF1-independent manner.2018
Author(s)
Yamazaki S, Odanaka M, Nishioka A, Kasuya S, Shime H, Hemmi H, Imai M, Riethmacher D, Kaisho T, Ohkura N, Sakaguchi S, Morita A.
Organizer
International Investigative Dermatology 2018
Related Report
Int'l Joint Research
-
-
-
-
-
-
-
[Presentation] The critical role of dendritic cell subset in expanding Foxp3+ regulatory T cells in the murine skin after ultraviolet B exposure2017
Author(s)
Yamazaki, S., Nishioka, A., Kasuya, S., Odanaka, M., Hemmi, H., Imai, M., Riethmacher, D., Kaisho, T., Ohkura, N., Sakaguchi, S., Morita, A
Organizer
LC2017 15th International Workshop on Langerhans Cells. NewYork, USA
Related Report
Int'l Joint Research
-
-
-
-
-
-
-
-
-
