| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2018: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2016: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
|
|---|
| Outline of Final Research Achievements |
In this study, we have identified bacterial strategy that counteracts host cell death. Shigella effector A targets host proteins for degradation to inhibit necroptosis of infected epithelial cells, and promote bacterial colonization. Furthermore, by comparing another enteric bacterial pathogens, we have revealed that inhibition of necroptosis by effector A homologs seems to be a universal infectious strategy for enteric bacterial pathogens.
|
