Cross-sectional analysis of infectious strategies of enteric bacterial pathogens
| Project/Area Number |
16H05186
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Bacteriology (including mycology)
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| Research Institution | Tokyo Medical and Dental University (2017-2018)
Chiba University (2016) |
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Principal Investigator |
ASHIDA HIROSHI 東京医科歯科大学, 大学院医歯学総合研究科, 准教授 (10535115)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2018: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2016: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
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| Keywords | エフェクター / 細胞死 / 腸管病原菌 / 腸管病原細菌 / 赤痢菌 / 病原細菌 / 自然免疫 |
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| Outline of Final Research Achievements |
In this study, we have identified bacterial strategy that counteracts host cell death. Shigella effector A targets host proteins for degradation to inhibit necroptosis of infected epithelial cells, and promote bacterial colonization. Furthermore, by comparing another enteric bacterial pathogens, we have revealed that inhibition of necroptosis by effector A homologs seems to be a universal infectious strategy for enteric bacterial pathogens.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究では、感染様式の異なる複数の腸管病原菌を用い、その感染現象を横断的に比較解析し、共通する感染戦略を解明した。本研究により得られた知見は幅広い腸管病原細菌を標的とする創薬・ワクチン開発へとつながることが期待される。
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Report
(4 results)
Research Products
(12 results)
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[Journal Article] Gut pathobionts underlie intestinal barrier dysfunction and liver T helper 17 cell immune response in primary sclerosing cholangitis.2019
Author(s)
Nakamoto N, Sasaki N, Aoki R, Miyamoto K, Suda W, Teratani T, Suzuki T, Koda Y, Chu PS, Taniki N, Yamaguchi A, Kanamori M, Kamada N, Hattori M, Ashida H, Sakamoto M, Atarashi K, Narushima S, Yoshimura A, Honda K, Sato T, Kanai T.
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Journal Title
Nat Microbiol.
Volume: 4
Issue: 3
Pages: 492-503
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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