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A study on medical and ethical validity of palliative sedation therapy in East Asia

Research Project

Project/Area Number 16H05212
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Medical sociology
Research InstitutionKyoto University

Principal Investigator

tsuneto satoru  京都大学, 医学研究科, 教授 (70372604)

Co-Investigator(Kenkyū-buntansha) 森田 達也  聖隷クリストファー大学, 看護学研究科, 臨床教授 (70513000)
木澤 義之  神戸大学, 医学部附属病院, 特命教授 (80289181)
Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2018: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2017: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2016: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Keywords鎮静 / 終末期 / 緩和ケア / 安楽死 / 治療抵抗性の苦痛 / バイオエシックス / 医療 / 緩和医療 / 癌
Outline of Final Research Achievements

This study examined medical and ethical validity of palliative sedation therapy. A questionnaire survey on Japanese palliative care specialists revealed that they approved palliative sedation with terms of proportionally reasonable predicted survival, refractoriness, and patient autonomy. A cross-sectional survey revealed the prevalence of palliative sedation was 8.5% in Japan, 13% in Korea, and 15% in Taiwan. Patients who received palliative sedation were; very close to death and suffering from serious refractory symptoms with relatively small dose of sedatives.

Academic Significance and Societal Importance of the Research Achievements

終末期がん患者の死亡直前の苦痛が十分に緩和されない時期の対応策(last resort)として、患者の意識を低下させることで苦痛を緩和する手段は、東アジアの専門緩和ケアサービスを受けている患者の約10%に実施されていたが、生命予後が日の単位と考えられる患者の治療抵抗性とみなされる苦痛に対して行われており、医学的・倫理的に妥当であると考えられた。

Report

(4 results)
  • 2019 Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • Research Products

    (5 results)

All 2018 2017 Other

All Int'l Joint Research (2 results) Journal Article (3 results) (of which Peer Reviewed: 3 results)

  • [Int'l Joint Research] College of Medicine and Hospital/National Taiwan University/Taipei Veterans General Hospital(台湾)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] Dongguk University Ulsan Hospital/Dongguk University School of Medicine/Ulsan University Hospital(韓国)

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Changes in opinions on palliative sedation of palliative care specialists over 16?years and their effects on clinical practice2018

    • Author(s)
      Maeda Sayaka、Morita Tatsuya、Ikenaga Masayuki、Abo Hirofumi、Kizawa Yoshiyuki、Tsuneto Satoru
    • Journal Title

      Supportive Care in Cancer

      Volume: 27 Issue: 6 Pages: 2211-2219

    • DOI

      10.1007/s00520-018-4497-2

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Nationwide Survey About Palliative Sedation Involving Japanese Palliative Care Specialists: Intentions and Key Factors Used to Determine Sedation as Proportionally Appropriate2018

    • Author(s)
      Hamano Jun、Morita Tatsuya、Ikenaga Masayuki、Abo Hirofumi、Kizawa Yoshiyuki、Tunetou Satoru
    • Journal Title

      Journal of Pain and Symptom Management

      Volume: 55 Issue: 3 Pages: 785-791

    • DOI

      10.1016/j.jpainsymman.2017.10.006

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Continuous Deep Sedation: A Proposal for Performing More Rigorous2017

    • Author(s)
      Morita T, Imai K, Yokomichi N, Mori M, Kizawa Y, Tsuneto S.
    • Journal Title

      Continuous Deep Sedation: A Proposal for Performing More Rigorous

      Volume: 53 Pages: 146-152

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed

URL: 

Published: 2016-04-21   Modified: 2022-08-05  

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