Effect of Japanese food component on marker of athrosclerosis, research using metabolome measurement

Research Project

Project/Area Number	16H05241
Research Category	Grant-in-Aid for Scientific Research (B)
Allocation Type	Single-year Grants
Section	一般
Research Field	Epidemiology and preventive medicine
Research Institution	Tohoku University
Principal Investigator	Atsushi Hozawa 東北大学, 東北メディカル・メガバンク機構, 教授 (00432302)
Research Collaborator	Nakamura Tomohiro Hirata Takumi Kogure Mana Oikawa Maki Kisara Fuko Yang Yunqing Igarashi Yuka Ichinohasama Fumi
Project Period (FY)	2016-04-01 – 2019-03-31
Project Status	Completed (Fiscal Year 2018)
Budget Amount *help	¥15,990,000 (Direct Cost: ¥12,300,000、Indirect Cost: ¥3,690,000) Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000) Fiscal Year 2017: ¥12,090,000 (Direct Cost: ¥9,300,000、Indirect Cost: ¥2,790,000) Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords	動脈硬化 / 疫学 / メタボローム / 日本食コンポーネント / 栄養
Outline of Final Research Achievements	We measured information on metabolome. Participants of this study was (1) participants of Tohoku Medical Megabank Community Cohort Study (2) who measured cervical intina medina thickness(IMT), and (3) whose IMT was upper 25% or lower 25%. We selected participants considering age sex subgroup. Finally, we completed metabolome measurement from 2002 participants. We analyzeｄ the relation of IMT thickness with 165 items of metabolome measured by LC-MS and 37 items of metabolome measured by NMR. As a result, 3 items measured by LC-MS and 9 items measured by NMR was significantly associated with IMT thickness adjusting for age and sex.
Academic Significance and Societal Importance of the Research Achievements	生活習慣が頸動脈硬化、ひいては脳心血管疾患に影響を与えることは良く知られている。しかしながらどのようなメカニズムを介して疾患につながるかはまだ明らかとはなっていない。本研究ではどのような代謝物質が動脈硬化肥厚者で高くなっているかを確認することを通じ、動脈硬化の早期マーカーをとらえることが可能になる。今後の創薬や早期診断マーカーの確立につながる意義のある研究であると考える。