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Attributable Causes of Cancer in Japan

Research Project

Project/Area Number 16H05244
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Epidemiology and preventive medicine
Research InstitutionNational Cancer Center Japan (2017-2018)
The University of Tokyo (2016)

Principal Investigator

Inoue Manami  国立研究開発法人国立がん研究センター, 社会と健康研究センター, 部長 (70250248)

Co-Investigator(Kenkyū-buntansha) 片野田 耕太  国立研究開発法人国立がん研究センター, がん対策情報センター, 部長 (00356263)
澤田 典絵  国立研究開発法人国立がん研究センター, 社会と健康研究センター, 室長 (00446551)
永田 知里  岐阜大学, 大学院医学系研究科, 教授 (30283295)
石原 淳子  麻布大学, 生命・環境科学部, 教授 (30415509)
林 櫻松  愛知医科大学, 医学部, 教授 (50340302)
高地 リベカ  奈良女子大学, 生活環境科学系, 教授 (60413085)
Research Collaborator TANAKA Junko  
SAITO Eiko  
UEDA Kayo  
GOTO Atsushi  
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥16,380,000 (Direct Cost: ¥12,600,000、Indirect Cost: ¥3,780,000)
Fiscal Year 2018: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2017: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Keywordsがん / 要因 / 人口寄与割合 / 予防 / 日本
Outline of Final Research Achievements

To contribute to evidence-based policy decision making for national cancer control, we estimated the burden of cancer attributable to major risk factors in Japan in 2015 (tobacco smoking, alcohol drinking, cancer related infectious agents, obesity, physical inactivity, diabetes, female hormone related factors, excess-salt intake, low-vegetable and fruit intake, air pollution etc.). Our estimates showed that these modifiable risk factors accounted for 45% of cancer incidence among men and 31% among women, and for 39% among both sexes, being suggested to be preventable. In addition, tobacco smoking, cancer-related infectious agents, and alcohol drinking were major attributable causes both in men and in women.

Academic Significance and Societal Importance of the Research Achievements

がんリスクの大きさをとらえる指標としては、要因のがんに対する相対危険度が多く用いられている。一方、要因の与える国全体への寄与度、すなわち負担の大きさを考える場合は、国全体における要因の保有割合を考慮した人口寄与割合が重要な指標となる。近年、わが国では、喫煙率やがん関連感染症の感染率など、要因によってはその保有割合が年代・世代によりダイナミックに変化していることから、現状に合う最新かつ精度の高い寄与度の推計が求められている。そのため、本研究はわが国における今後のがん対策へ大きく貢献する必須のエビデンスとなる。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • Research Products

    (18 results)

All 2018 2017 2016

All Journal Article (4 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 4 results,  Open Access: 4 results) Presentation (14 results) (of which Int'l Joint Research: 6 results,  Invited: 9 results)

  • [Journal Article] Changing trends in the prevalence of H. pylori infection in Japan (1908-2003): a systematic review and meta-regression analysis of 170,752 individuals.2017

    • Author(s)
      Wang C, Nishiyama T, Kikuchi S, Inoue M, Sawada N, Tsugane S, Lin Y.
    • Journal Title

      Sci Rep

      Volume: 7(1) Issue: 1 Pages: 15491-15491

    • DOI

      10.1038/s41598-017-15490-7

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Estimation of lifetime cumulative incidence and mortality risk of gastric cancer.2017

    • Author(s)
      Taniyama Y, Katanoda K, Charvat H, Hori M, Ohno Y, Sasazuki S, Tsugane S
    • Journal Title

      Jpn J Clin Oncol

      Volume: 47(11) Issue: 11 Pages: 1097-1102

    • DOI

      10.1093/jjco/hyx128

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Fruit and vegetable intake and the risk of overall cancer in Japanese: A pooled analysis of population-based cohort studies2017

    • Author(s)
      Takachi R, Inoue M, Sugawara Y, Tsuji I, Tsugane S, Ito H, Matsuo K, Tanaka K, Tamakoshi A, Mizoue T, Wakai K, Nagata C, Sasazuki S
    • Journal Title

      Journal of Epidemiology

      Volume: 27 Issue: 4 Pages: 152-162

    • DOI

      10.1016/j.je.2016.05.004

    • NAID

      130005611982

    • ISSN
      0917-5040, 1349-9092
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Changing epidemiology of Helicobacter pylori in Japan2017

    • Author(s)
      Inoue M
    • Journal Title

      Gastric Cancer

      Volume: 20 suppl 1 Issue: S1 Pages: 3-7

    • DOI

      10.1007/s10120-016-0658-5

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] わが国における出生年別にみたHCV及びHBV感染保有率の推計2018

    • Author(s)
      井上真奈美
    • Organizer
      日本人間ドック学会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Cancer Prevention and Control in Japan2018

    • Author(s)
      Manami Inoue
    • Organizer
      Asia Pacific Organization of Cancer Prevention Regional Meeting in China
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Inspiring the National Cancer Prevention Strategies in Japan2018

    • Author(s)
      Manami Inoue
    • Organizer
      World Cancer Congress 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 胃がんの原因と予防2018

    • Author(s)
      井上真奈美
    • Organizer
      第90回日本胃癌学会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Attributable Causes of Cancer in Japan2017

    • Author(s)
      Inoue M
    • Organizer
      The 24th Asia Pacific Cancer Conference
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Asian Cohort Studies Collaboration2017

    • Author(s)
      Inoue M
    • Organizer
      The first Middle Eastern Population Health Research Conference
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 日本人における H. pylori 感染率に関するシステマティックレビュー及びメタ回帰分析2017

    • Author(s)
      林 櫻松
    • Organizer
      第23回日本ヘリコバクター学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Cancer prevention research in Japan2016

    • Author(s)
      Inoue M
    • Organizer
      International Conference on the 21st Annual Meeting of the Korean Society of Cancer Prevention
    • Place of Presentation
      Grand Hilton Hotel, Seoul, Korea
    • Year and Date
      2016-12-08
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] わが国のピロリ菌感染と胃がんの現状2016

    • Author(s)
      林 櫻松、王超辰、菊地正悟
    • Organizer
      第75回日本公衆衛生学会総会
    • Place of Presentation
      グランフロント大阪
    • Year and Date
      2016-10-26
    • Related Report
      2016 Annual Research Report
  • [Presentation] Epidemiology of stomach cancer2016

    • Author(s)
      Inoue M
    • Organizer
      2016 International Symposium on Epidemioloogy of Upper Gastrointestinal Cancers
    • Place of Presentation
      Fujian Medical University, Fuzhou, China
    • Year and Date
      2016-09-18
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 疫学研究における前向きコホート2016

    • Author(s)
      井上真奈美
    • Organizer
      がん予防学術大会
    • Place of Presentation
      名古屋大学医学部
    • Year and Date
      2016-07-01
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] コホート内症例対照研究によるH. pylori感染と心血管疾患の関連についての検討2016

    • Author(s)
      林 櫻松、小幡由紀、王超辰、菊地正悟
    • Organizer
      第22回日本ヘリコバクター学会学術集会
    • Place of Presentation
      別府国際コンベンションセンター B-Con Plaza
    • Year and Date
      2016-06-24
    • Related Report
      2016 Annual Research Report
  • [Presentation] 中学生の学校検診におけるH. pylori抗体検査陽性者の臨床像2016

    • Author(s)
      中山 佳子、 草刈 麻衣、 加藤 沢子、日高 奈緒、 林 櫻松、菊地 正悟、 本郷 実
    • Organizer
      第22回日本ヘリコバクター学会学術集会
    • Place of Presentation
      別府国際コンベンションセンター B-Con Plaza
    • Year and Date
      2016-06-24
    • Related Report
      2016 Annual Research Report
  • [Presentation] 胃癌リスク評価のための新しいピロリ菌抗体測定キット開発の提案2016

    • Author(s)
      菊地正悟、荒井健介、王超辰、林櫻松
    • Organizer
      第22回日本ヘリコバクター学会学術集会
    • Place of Presentation
      別府国際コンベンションセンター B-Con Plaza
    • Year and Date
      2016-06-24
    • Related Report
      2016 Annual Research Report

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Published: 2016-04-21   Modified: 2020-03-30  

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