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Elucidation of the mechanisms of neoatherosclerosis and degenerative vascular disease and development of novel therapeutic strategy

Research Project

Project/Area Number 16H05297
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Cardiovascular medicine
Research InstitutionKyoto University

Principal Investigator

Kimura Takeshi  京都大学, 医学研究科, 教授 (80359786)

Co-Investigator(Kenkyū-buntansha) 尾野 亘  京都大学, 医学研究科, 准教授 (00359275)
芦田 昇  京都大学, 医学研究科, 講師 (00538978)
齋藤 成達  京都大学, 医学研究科, 助教 (20467484)
西 英一郎  滋賀医科大学, 医学部, 教授 (30362528)
森本 剛  兵庫医科大学, 医学部, 教授 (30378640)
今井 逸雄  京都大学, 医学研究科, 特定病院助教 (10625677)
伯野 大彦  京都大学, 医学研究科, 医員 (80286476)
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2018: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2017: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2016: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
Keywordsneoatherosclerosis / 大動脈弁狭窄症 / microRNA / nardilysin / ステント / Neoatherosclerosis / マイクロRNA / 退行性血管病変 / 大動脈弁狭窄 / NRDc / 動脈硬化 / 冠動脈疾患 / バイオマーカー / 病理 / ステント血栓症 / デバイス
Outline of Final Research Achievements

In order to elucidate the mechanisms of neoatherosclerosis and pathogenesis of degenerative vessel diseases, we conducted large scale observation studies, histo-pathological examination of human samples, and research on animal models. We also trying to develop new devices for the treatment of cardiovascular diseases. Contribution of microRNA-33b in the development of unstable plaques and usefulness of measurement of serum nardilysin in the diagnosis of myocardial infarction were clarified. Moreover, it was revealed that asymptomatic patients with severe AS was dismal when managed conservatively in this real-world analysis and might be substantially improved by an initial AVR strategy.

Academic Significance and Societal Importance of the Research Achievements

申請者らは、これまでに動脈硬化に関し多くの基礎実験を重ね、また大規模臨床データを集積して、その治療法に関する提言を行ってきた。今回、大規模臨床データの集積と病理像の解析、さらに基礎的研究を有機的につなげて、ステント治療後の冠動脈病変と大動脈弁狭窄症における課題と治療法に関する研究を行った。不安定プラークにおけるmicroRNA-33bの役割、Nardilysinの心筋梗塞マーカーとしての有用性、大動脈弁狭窄症に対する治療法の改善が必要であることなどが明らかとなった。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Annual Research Report
  • 2016 Annual Research Report

Research Products

(69 results)

All 2019 2018 2017 2016 Other

All Journal Article (40 results) (of which Int'l Joint Research: 6 results,  Peer Reviewed: 33 results,  Open Access: 24 results,  Acknowledgement Compliant: 3 results) Presentation (27 results) (of which Int'l Joint Research: 21 results,  Invited: 12 results) Remarks (1 results) Patent(Industrial Property Rights) (1 results) (of which Overseas: 1 results)

  • [Journal Article] Open-Label Randomized Trial Comparing Oral Anticoagulation With and Without Single Antiplatelet Therapy in Patients With Atrial Fibrillation and Stable Coronary Artery Disease Beyond 1 Year After Coronary Stent Implantation2019

    • Author(s)
      Matsumura-Nakano Y, Shizuta S, Komasa A, Morimoto T, Masuda H et al.
    • Journal Title

      Circulation.

      Volume: 139 Pages: 604-616

    • DOI

      10.1161/circulationaha.118.036768

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prognostic impacto of left ventricular ejection fraction in patients with severe aortic stenosis2018

    • Author(s)
      Taniguchi T, Morimoto T, Shiomi H, Ando K, Kanamori N, Murata K, Kitai T, Kadota K, Izumi C, Nakatsuma K, Sasa T, Watanabe H, Kuwabara Y, Makiyama T, Ono K, Shizuta S, Kato T, Saito N, Minatoya K, Kimura T.
    • Journal Title

      JACC Cardiovasc Interv.

      Volume: 11 Pages: 145-157

    • DOI

      10.1016/j.jcin.2017.08.036

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Utility of a 3-Dimensional Printed Model to Simulate Transcatheter Aortic Valve Implantation in a Patient With an Intramural Hematoma and a Penetrating Atherosclerotic Ulcer in the Distal Aortic Arch2018

    • Author(s)
      Yaku Hidenori、Saito Naritatsu、Imai Masao、Sakamoto Kazuhisa、Toyota Toshiaki、Watanabe Hirotoshi、Taniguchi Tomohiko、Shiomi Hiroki、Imada Kazuaki、Seo Hideya、Yamazaki Kazuhiro、Kimura Takeshi
    • Journal Title

      Circulation. Cardiovascular interventions

      Volume: 11

    • DOI

      10.1161/circinterventions.118.006925

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Validation of simplified PESI score for identification of low-risk patients with pulmonary embolism: From the COMMAND VTE Registry2018

    • Author(s)
      Yamashita Yugo、Morimoto Takeshi、Amano Hidewo、Takase Toru、Hiramori Seiichi、Shiomi Hiroki、Kato Takao、Makiyama Takeru、Ono Koh、Kimura Takeshi et al.
    • Journal Title

      European Heart Journal: Acute Cardiovascular Care

      Volume: -

    • DOI

      10.1177/2048872618799993

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Deletion of IκB-Kinase β in Smooth Muscle Cells Induces Vascular Calcification Through β-Catenin-Runt-Related Transcription Factor 2 Signaling.2018

    • Author(s)
      Al-Huseini I, Ashida N, Kimura T.
    • Journal Title

      Journal of the American Heart Association

      Volume: 7

    • DOI

      10.1161/jaha.117.007405

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Validating Utility of Dual Antiplatelet Therapy Score in a Large Pooled Cohort From 3 Japanese Percutaneous Coronary Intervention Studies.2018

    • Author(s)
      Yoshikawa Y, Shiomi H, Watanabe H, Natsuaki M, Kondo H, Tamura T, Nakagawa Y, Morimoto T, Kimura T.
    • Journal Title

      Circulation

      Volume: 137 Pages: 551-562

    • DOI

      10.1161/circulationaha.117.028924

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Differences Between Fractional Flow Reserve and Instantaneous Wave-Free Ratio Clarified by Consideration of a Mathematical Model of Diffuse Coronary Stenosis2018

    • Author(s)
      Yoshikawa Yusuke、Saito Naritatsu.
    • Journal Title

      JACC: Cardiovascular Interventions

      Volume: 11 Pages: 1903-1904

    • DOI

      10.1016/j.jcin.2018.07.022

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Influence of a history of cancer on long-term cardiovascular outcomes after coronary stent implantation (an Observation from Coronary Revascularization Demonstrating Outcome Study-Kyoto Registry Cohort-2)2018

    • Author(s)
      Nakatsuma Kenji、Shiomi Hiroki、Morimoto Takeshi、Watanabe Hirotoshi、Nakagawa Yoshihisa、Furukawa Yutaka、Kadota Kazushige、Ando Kenji、Ono Koh、Shizuta Satoshi、Kimura Takeshi、CREDO-Kyoto PCI/CABG Registry Cohort-2 Investigators
    • Journal Title

      European Heart Journal - Quality of Care and Clinical Outcomes

      Volume: 4 Pages: 200-207

    • DOI

      10.1093/ehjqcco/qcy014

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Loss of periostin ameliorates adipose tissue inflammation and fibrosis in vivo2018

    • Author(s)
      Nakazeki Fumiko、Nishiga Masataka、Horie Takahiro、Nishi Hitoo、Nakashima Yasuhiro、Baba Osamu、Kuwabara Yasuhide、Nishino Tomohiro、Nakao Tetsushi、Ide Yuya、Koyama Satoshi、Kimura Masahiro、Tsuji Shuhei、Sowa Naoya、Yoshida Shigeo、Conway Simon J.、Yanagita Motoko、Kimura Takeshi、Ono Koh
    • Journal Title

      Scientific Reports

      Volume: 8 Pages: 1-14

    • DOI

      10.1038/s41598-018-27009-9

    • NAID

      120006510274

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] SREBF1/MicroRNA-33b Axis Exhibits Potent Effect on Unstable Atherosclerotic Plaque Formation In Vivo2018

    • Author(s)
      Nishino T、Horie T、Baba O、Sowa N、Hanada R、Kuwabara Y、Nakao T、Nishiga M、Nishi H、Nakashima Y、Nakazeki F、Ide Y、Koyama S、Kimura M、Nagata M、Yoshida K、Takagi Y、Nakamura T、Hasegawa K、Miyamoto S、Kimura T、Ono K.
    • Journal Title

      Arteriosclerosis, Thrombosis, and Vascular Biology

      Volume: 38 Pages: 2460-2473

    • DOI

      10.1161/atvbaha.118.311409

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] High-Dose Versus Low-Dose Pitavastatin in Japanese Patients With Stable Coronary Artery Disease (REAL-CAD)2018

    • Author(s)
      Taguchi Isao、Iimuro Satoshi、Iwata Hiroshi、et.al 、Nagai Ryozo
    • Journal Title

      Circulation

      Volume: 137 Pages: 1997-2009

    • DOI

      10.1161/circulationaha.117.032615

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Nardilysin controls intestinal tumorigenesis through HDAC1/p53-dependent transcriptional regulation.2018

    • Author(s)
      Kanda K, Sakamoto J, Matsumoto Y, Ikuta K, Goto N, Morita Y, Ohno M, Nishi K, Eto K, Kimura Y, Nakanishi Y, Ikegami K, Yoshikawa T, Fukuda A, Kawada K, Sakai Y, Ito A, Yoshida M, Kimura T, Chiba T, Nishi E, Seno H.
    • Journal Title

      JCI insight

      Volume: 3 Issue: 8 Pages: 1-15

    • DOI

      10.1172/jci.insight.91316

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Bioresorbable Scaffold for Treatment of Coronary Artery Lesions: Intravascular Ultrasound Results From the ABSORB Japan Trial.2018

    • Author(s)
      Okada K, Honda Y, Kitahara H, Otagiri K, Tanaka S, Hollak MB, Yock PG, Popma JJ, Kusano H, Cheong WF, Sudhir K, Fitzgerald PJ, Kimura T; ABSORB Japan Investigators.
    • Journal Title

      JACC Cardiovasc Interv.

      Volume: 11 Pages: 648-661

    • DOI

      10.1016/j.jcin.2017.11.034

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Malignant Disease as a Comorbidity in Patients with Severe Aortic Stenosis: Clinical Presentation, Outcomes, and Management.2018

    • Author(s)
      Minamino-Muta E, Kato T, Kimura T, at al.
    • Journal Title

      Eur Heart J Qual Care Clin Outcomes.

      Volume: 印刷中

    • DOI

      10.1093/ehjqcco/qcy010

    • NAID

      120006551773

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Long Non-Coding RNAs as Key Regulators of Cardiovascular Diseases2018

    • Author(s)
      Ono K, Kuwabara Y, Horie T, Kimura T.
    • Journal Title

      Circ J

      Volume: 印刷中 Issue: 5 Pages: 1231-1236

    • DOI

      10.1253/circj.cj-18-0169

      10.1253/circj.CJ-18-0169

    • NAID

      130006725985

    • ISSN
      1346-9843, 1347-4820
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Causes of Death in Patients with Severe Aortic Stenosis: An Observational study.2017

    • Author(s)
      Minamino-Muta E, Kato T, Kimura T, at al.
    • Journal Title

      Sci Rep.

      Volume: 7 Pages: 14723-14723

    • DOI

      10.1038/s41598-017-15316-6

    • NAID

      120006364093

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Genome-wide profiling of nardilysin target genes reveals its role in epigenetic regulation and cell cycle progression2017

    • Author(s)
      Morita Y, Ohno M, Nishi K, Hiraoka Y, Saijo S, Matsuda S, Kita T, Kimura T, Nishi E.
    • Journal Title

      Scientific Reports

      Volume: 7 Pages: 14801-14801

    • DOI

      10.1038/s41598-017-14942-4

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Genetic Ablation of MicroRNA-33 Attenuates Inflammation and Abdominal Aortic Aneurysm Formation via Several Anti-Inflammatory Pathways.2017

    • Author(s)
      Nakao T, Horie T, Baba O, Nishiga M, Nishino T, Izuhara M, Kuwabara Y, Nishi H, Usami S, Nakazeki F, Ide Y, Koyama S, Kimura M, Sowa N, Ohno S, Aoki H, Hasegawa K, Sakamoto K, Minatoya K, Kimura T, Ono K.
    • Journal Title

      Arteriosclerosis, Thrombosis, and Vascular Biology

      Volume: 37 Pages: 2161-2170

    • DOI

      10.1161/atvbaha.117.309768

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dual Antithrombotic Therapy with Dabigatran after PCI in Atrial Fibrillation.2017

    • Author(s)
      Cannon CP, Bhatt DL, Oldgren J, Lip GYH, Ellis SG, Kimura T, Maeng M, Merkely B, Zeymer U, Gropper S, Nordaby M, Kleine E, Harper R, Manassie J, Januzzi JL, Ten Berg JM, Steg PG, Hohnloser SH; RE-DUAL PCI Steering Committee and Investigators.
    • Journal Title

      N Engl J Med.

      Volume: 377 Pages: 1513-1524

    • DOI

      10.1056/nejmoa1708454

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Prognostic Impact of Peak Aortic Jet Velocity in Conservatively Managed Patients With Severe Aortic Stenosis: An Observation From the CURRENT AS Registry.2017

    • Author(s)
      Nakatsuma K, Taniguchi T, Kimura T, at al.
    • Journal Title

      J Am Heart Assoc.

      Volume: 6

    • DOI

      10.1161/jaha.117.005524

    • NAID

      120006876600

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Severe Aortic Stenosis in Dialysis Patients.2017

    • Author(s)
      Kawase Y, Taniguchi T, Morimoto T, Kadota K, Iwasaki K, Kuwayama A, Ohya M, Shimada T, Amano H, Maruo T, Fuku Y, Izumi C, Kitai T, Saito N, Minamino-Muta E, Kato T, Inada T, Inoko M, Ishii K, Komiya T, Hanyu M, Minatoya K, Kimura T; CURRENT AS Registry Investigators.
    • Journal Title

      J Am Heart Assoc.

      Volume: 6

    • DOI

      10.1161/jaha.116.004961

    • NAID

      120006876599

    • Related Report
      2017 Annual Research Report
  • [Journal Article] High- Versus Low-Gradient Severe Aortic Stenosis: Demographics, Clinical Outcomes, and Effects of the Initial Aortic Valve Replacement Strategy on Long-Term Prognosis.2017

    • Author(s)
      Taniguchi T, Morimoto T, Kimura T, at al.
    • Journal Title

      Circ Cardiovasc Interv.

      Volume: 10

    • DOI

      10.1161/circinterventions.116.004796

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Allele-specific Ablation Rescues Electrophysiological Abnormalities in a Human iPS Cell Model of Long-QT Syndrome with a CALM2 Mutation.2017

    • Author(s)
      Yamamoto Y, Horie M, et al.
    • Journal Title

      Hum Mol Genet.

      Volume: 印刷中 Pages: 1670-1677

    • DOI

      10.1093/hmg/ddx073

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Incidence and Prognostic Impact of Heart Failure Hospitalization During Follow-up after Primary Percutaneous Coronary Intervention in ST-segment Elevation Myocardial Infarction.2017

    • Author(s)
      Taniguchi T, Horie M, et al.
    • Journal Title

      Am J Cardiol.

      Volume: 印刷中 Pages: 1729-1739

    • DOI

      10.1016/j.amjcard.2017.03.013

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relation of ST-Segment Elevation Myocardial Infarction to Daily Ambient Temperature and Air Pollutant Levels in a Japanese Nationwide Percutaneous Coronary Intervention Registry.2017

    • Author(s)
      Yamaji K, Kohsaka S, Morimoto T, Fujii K, Amano T, Uemura S, Akasaka T, Kadota K, Nakamura M, Kimura T; J-PCI Registry Investigators.
    • Journal Title

      Am J Cardiol.

      Volume: 15 Pages: 872-880

    • DOI

      10.1016/j.amjcard.2016.11.041

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The ReACT Trial: Randomized Evaluation of Routine Follow-up Coronary Angiography After Percutaneous Coronary Intervention Trial.2017

    • Author(s)
      Shiomi H, Morimoto T, Ishii K, Nakao K, Aoyama Y, Takeda T, Murata K, Akao M, Inada T, Eizawa H, Hyakuna E, Awano K, Shirotani M, Furukawa Y, Kadota K, Miyauchi K, Tanaka M, Noguchi Y, Nakamura S, Yasuda S, Miyazaki S, Daida H, Kimura K, Ikari Y, Hirayama H, Sumiyoshi T, Kimura T; ReACT Investigators
    • Journal Title

      JACC Cardiovasc Interv.

      Volume: 23 Pages: 109-117

    • DOI

      10.1016/j.jcin.2016.10.018

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Very Late Scaffold Thrombosis of Bioresorbable Vascular Scaffold: Systematic Review and a Meta-Analysis.2017

    • Author(s)
      Toyota T, Morimoto T, Shiomi H, Yoshikawa Y, Yaku H, Yamashita Y, Kimura T.
    • Journal Title

      JACC Cardiovasc Interv.

      Volume: 9 Pages: 27-37

    • DOI

      10.1016/j.jcin.2016.10.027

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cardiac and Noncardiac Causes of Long-Term Mortality in ST-Segment-Elevation Acute Myocardial Infarction Patients Who Underwent Primary Percutaneous Coronary Intervention.2017

    • Author(s)
      Yamashita Y, Shiomi H, Morimoto T, Yaku H, Furukawa Y, Nakagawa Y, Ando K, Kadota K, Abe M, Nagao K, Shizuta S, Ono K, Kimura T; CREDO-Kyoto AMI Registry Investigators.
    • Journal Title

      Circ Cardiovasc Qual Outcomes.

      Volume: 10

    • DOI

      10.1161/circoutcomes.116.002790

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] MicroRNA-33 Controls Adaptive Fibrotic Response in the Remodeling Heart by Preserving Lipid Raft Cholesterol.2017

    • Author(s)
      Nishiga M, Horie T, Kuwabara Y, Nagao K, Baba O, Nakao T, Nishino T, Hakuno D, Nakashima Y, Nishi H, Nakazeki F, Ide Y, Koyama S, Kimura M, Hanada R, Nakamura T, Inada T, Hasegawa K, Conway SJ, Kita T, Kimura T, Ono K.
    • Journal Title

      Circ Res

      Volume: - Pages: 835-847

    • DOI

      10.1161/circresaha.116.309528

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Favorable Clinical Outcomes of Transcatheter Aortic Valve Implantation in Japanese Patients ― First Report From the Post-Approval K-TAVI Registry ―2017

    • Author(s)
      Takimoto S, Saito N, Minakata K, Shirai S, Isotani A, Arai Y, Hanyu M, Komiya T, Shimamoto T, Goto T, Fuku Y, Ehara N, Furukawa Y, Koyama T, Nagasawa A, Tamura T, Miyake M, Yamanaka K, Sakaguchi H, Murata K, Onodera T, Yamazaki F, Nakai M, Taniguchi T, Sakata R, Kimura T.
    • Journal Title

      Circ J

      Volume: 22 Issue: 1 Pages: 103-109

    • DOI

      10.1253/circj.cj-16-0546

      10.1253/circj.CJ-16-0546

    • NAID

      130005252648

    • ISSN
      1346-9843, 1347-4820
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Impact of Low Diastolic Blood Pressure on Risk of Cardiovascular Death in Elderly Patients With Coronary Artery Disease After Revascularization – The CREDO-Kyoto Registry Cohort-1 –2016

    • Author(s)
      Kai H, Kimura T, Fukuda K, Fukumoto Y, Kakuma T, Furukawa Y; CREDO-Kyoto Investigators.
    • Journal Title

      Circ J

      Volume: 25 Issue: 5 Pages: 1232-1241

    • DOI

      10.1253/circj.cj-15-1151

      10.1253/circj.CJ-15-1151

    • NAID

      130005147673

    • ISSN
      1346-9843, 1347-4820
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Long-term clinical outcomes in patients with ST-segment elevation acute myocardial infarction complicated by cardiogenic shock due to acute pump failure.2016

    • Author(s)
      Kawaji T, Shiomi H, Morimoto T, Furukawa Y, Nakagawa Y, Kadota K, Ando K, Mizoguchi T, Abe M, Takahashi M, Kimura T; CREDO-Kyoto AMI investigators.
    • Journal Title

      Eur Heart J Acute Cardiovasc Care.

      Volume: -

    • DOI

      10.1177/2048872616673535

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Different clinical outcomes in patients with asymptomatic severe aortic stenosis according to the stage classification: Does the aortic valve area matter?2016

    • Author(s)
      Kitai T, Taniguchi T, Morimoto T, Toyota T, Izumi C, Kaji S, Kim K, Saito N, Nagao K, Inada T, Minamino-Muta E, Kato T, Inoko M, Ishii K, Koyama T, Sakata R, Furukawa Y, Kimura T; CURRENT AS registry Investigators.
    • Journal Title

      Int J Cardiol.

      Volume: 11 Pages: 244-252

    • DOI

      10.1016/j.ijcard.2016.11.092

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Adaptive servoventilation versus oxygen therapy for sleep disordered breathing in patients with heart failure: a randomised trial.2016

    • Author(s)
      Murase K, Ono K, Yoneda T, Iguchi M, Yokomatsu T, Mizoguchi T, Izumi T, Akao M, Miki S, Nohara R, Ueshima K, Mishima M, Kimura T, White DP, Chin K.
    • Journal Title

      Open Heart.

      Volume: 31

    • DOI

      10.1136/openhrt-2015-000366

    • NAID

      120005997791

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Inter-Facility Transfer vs. Direct Admission of Patients With ST-Segment Elevation Acute Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention2016

    • Author(s)
      Nakatsuma K, Shiomi H, Morimoto T, Furukawa Y, Nakagawa Y, Ando K, Kadota K, Yamamoto T, Suwa S, Horie M, Kimura T; CREDO-Kyoto AMI investigators.
    • Journal Title

      Circ J

      Volume: 25 Issue: 8 Pages: 1764-1772

    • DOI

      10.1253/circj.cj-16-0204

      10.1253/circj.CJ-16-0204

    • NAID

      130005166115

    • ISSN
      1346-9843, 1347-4820
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Nardilysin is required for maintaining pancreatic β-Cell Function.2016

    • Author(s)
      Nishi K, Sato Y, Ohno M, Hiraoka Y, Saijo S, Sakamoto J, Chen P-M, Morita Y, Matsuda S, Iwasaki K, Sugizaki K, Harada N, Mukumoto Y, Kiyonari H, Furuyama K, Kawaguchi Y, Uemoto S, Kita T, Inagaki N, Kimura T and Nishi E
    • Journal Title

      Diabetes.

      Volume: 65 Pages: 3015-27

    • DOI

      10.2337/db16-0178

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Long-Term Outcomes After Stent Implantation for Left Main Coronary Artery (from the Multicenter Assessing Optimal Percutaneous Coronary Intervention for Left Main Coronary Artery Stenting Registry).2016

    • Author(s)
      Ohya M, Kadota K, Toyofuku M, Morimoto T, Higami H, Fuku Y, Yamaji K, Muranishi H, Yamaji Y, Nishida K, Furukawa D, Tada T, Ko E, Ando K, Sakamoto H, Tamura T, Kawai K, Kimura T; AOI LMCA Stenting Registry Investigators.
    • Journal Title

      Am J Cardiol.

      Volume: -

    • DOI

      10.1016/j.amjcard.2016.10.033

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Two-year clinical, angiographic, and serial optical coherence tomographic follow-up after implantation of an everolimus-eluting bioresorbable scaffold and an everolimus-eluting metallic stent: insights from the randomised ABSORB Japan trial.2016

    • Author(s)
      Onuma Y, Sotomi Y, Shiomi H, Ozaki Y, Namiki A, Yasuda S, Ueno T, Ando K, Furuya J, Igarashi K, Kozuma K, Tanabe K, Kusano H, Rapoza R, Popma JJ, Stone GW, Simonton C, Serruys PW, Kimura T.
    • Journal Title

      EuroIntervention.

      Volume: 20 Pages: 1090-1101

    • DOI

      10.4244/eijy16m09_01

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Very Long-Term (10 to 14 Year) Outcomes After Percutaneous Coronary Intervention Versus Coronary Artery Bypass Grafting for Multivessel Coronary Artery Disease in the Bare-Metal Stent Era.2016

    • Author(s)
      Shiomi H, Yamaji K, Morimoto T, Shizuta S, Nakatsuma K, Higami H, Furukawa Y, Nakagawa Y, Kadota K, Ando K, Sakata R, Okabayashi H, Hanyu M, Shimamoto M, Nishiwaki N, Komiya T, Kimura T.
    • Journal Title

      Circ Cardiovasc Interv.

      Volume: 9

    • DOI

      10.1161/circinterventions.115.003365

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Is quantitative coronary angiography reliable in assessing the lumen gain after treatment with the everolimus-eluting bioresorbable polylactide scaffold?2016

    • Author(s)
      Sotomi Y, Onuma Y, Suwannasom P, Tateishi H, Tenekecioglu E, Zeng Y, Cavalcante R, Jonker H, Dijkstra J, Foin N, Koon JN, Collet C, de Winter RJ, Wykrzykowska JJ, Stone GW, Popma JJ, Kozuma K, Tanabe K, Serruys PW, Kimura T.
    • Journal Title

      EuroIntervention.

      Volume: 10

    • DOI

      10.4244/eijv12i8a163

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] High-intensity pitavastatin therapy further improves clinical outcomes in2018

    • Author(s)
      Takeshi Kimura.
    • Organizer
      86th EAS CONGRESS
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Optimal Lipid Lowering Therapy in Japanese Patients: REAL-CAD and2018

    • Author(s)
      Takeshi Kimura.
    • Organizer
      Asian Pacific Society of Cardiology (APSC) Congress
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Optimal antithrombotic treatment beyond the first year post PCI for ACS.2018

    • Author(s)
      Takeshi Kimura.
    • Organizer
      ESC Congress 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Complementary Role of Randomized Trials and Registry.2018

    • Author(s)
      木村 剛
    • Organizer
      第 82 回 日本循環器学会学術集会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 日本最大の大規模臨床試験 REAL-CAD の報告2018

    • Author(s)
      木村 剛
    • Organizer
      第 82 回 日本循環器学会学術集会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Novel Long Intergenic Noncoding RNA, Lionheart, Guards the Heart from Pressure Overload2018

    • Author(s)
      Kuwabara Y, Horie T, Baba O, Nishiga M, Nakao M, Nishino T, Nakazeki F, Koyama S, Kimura T, Ono K
    • Organizer
      第82回日本循環器学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] MicroRNA-33b promotes atherosclerotic plaque formation in Apoe-/- mice2018

    • Author(s)
      Nishino T, Horie T, Baba O, Kuwabara Y, Hakuno D, Nakashima Y, Nakao T, Nishiga M, Kimura T, Ono K
    • Organizer
      第82回日本循環器学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Molecular Links between Lipid Metabolism and Heart Failure.2017

    • Author(s)
      Koh Ono, Masataka Nishiga, Takahiro Horie, Takeshi Kimura.
    • Organizer
      第81回 日本循環器学会学術集会
    • Place of Presentation
      石川県立音楽堂外(石川県金沢市)
    • Year and Date
      2017-03-17
    • Related Report
      2016 Annual Research Report
  • [Presentation] MicroRNA-33b promotes atherosclerotic plaque formation in Apoe-/- mice2017

    • Author(s)
      Ono K, Nishino T, Horie T, Kuwabara Y, Nakao T, Nishiga M, Ide Y, Nakazeki F, Koyama S, Kimura M, Kimura T.
    • Organizer
      43rd Naito Conference Noncoding RNA
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] MicroRNA-33b promotes atherosclerotic plaque formation in Apoe-/- mice.2017

    • Author(s)
      Nishino T, Horie T, Kuwabara Y, Nakao T, Nishiga M, Ide Y, Nakazeki F, Koyama S, Kimura M, Kimura T, Ono K
    • Organizer
      American Heart Association Scientific Sessions 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Nuturitional status in acute decompensated heart failure waas slosely linked to high in-hospital mortality2017

    • Author(s)
      Kato T, Sasaki K, Kimura T
    • Organizer
      ESC Congress
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Post discharge myocardial infarction after percutaneous coronary intervention: incidence, risk factors, size distributuion2017

    • Author(s)
      Watanabe H, Morimoto T, Kimura T.
    • Organizer
      ESC Congress
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A rondamized controlled trial evaluating the efficacy of long-term use of beta-blocker in patients with ST-segment elevation myocardial infarction terated with primary percutaneous coronary intervention2017

    • Author(s)
      Watanabe H, Ozasa N, Kimura T.
    • Organizer
      ESC Congress
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Imaging iPSC-derived cardiomyocytes engrafted in a mouse model of myocardial infarction using stably expressed APEX2.2017

    • Author(s)
      Hatani T, Funakoshi S, Kimura T.
    • Organizer
      American Heart Association Scientific Sessions 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Single-session versus staged procedures for elective multi-vessel percutaneous coronary intervention.2017

    • Author(s)
      Toyota T, Morimoto T, Kimura T.
    • Organizer
      American Heart Association Scientific Sessions 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Very late scaffold thrombosis of biodegradable vascular scaffold.2017

    • Author(s)
      Toyota T, Morimoto T, Kimura T.
    • Organizer
      EuroPCR 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ABSORB Japan Clinical Outcomes at 2 Years.2016

    • Author(s)
      Takeshi Kimura.
    • Organizer
      TCT2016
    • Place of Presentation
      Washinton(アメリカ合衆国)
    • Year and Date
      2016-10-29
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] BRS, is it appropiate or wrong choice for patients undergoing.2016

    • Author(s)
      Takeshi Kimura.
    • Organizer
      ENCORE SEOUL 2016
    • Place of Presentation
      Seoul(大韓民国)
    • Year and Date
      2016-10-05
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Bioresorbable Vascular Scaffold: Observations from ABSORB Japan.2016

    • Author(s)
      Takeshi Kimura.
    • Organizer
      ENCORE SEOUL 2016
    • Place of Presentation
      Seoul(大韓民国)
    • Year and Date
      2016-10-05
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 完全生体吸収性スキャフォールドの現状と課題2016

    • Author(s)
      木村 剛
    • Organizer
      第64回日本心臓病学会学術集会
    • Place of Presentation
      東京国際フォーラム(東京都)
    • Year and Date
      2016-09-23
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Future direction for research in complex PCI.2016

    • Author(s)
      Takeshi Kimura.
    • Organizer
      ESC Congress 2016
    • Place of Presentation
      Roma(イタリア)
    • Year and Date
      2016-08-27
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ABSORB Japan.2016

    • Author(s)
      Takeshi Kimura.
    • Organizer
      ESC Congress 2016
    • Place of Presentation
      Roma(イタリア)
    • Year and Date
      2016-08-27
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Imaging for bioresorbable scaffolds - An Asian perspective.3.2016

    • Author(s)
      Takeshi Kimura.
    • Organizer
      ESC Congress 2016
    • Place of Presentation
      Roma(イタリア)
    • Year and Date
      2016-08-27
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Very Long-Term Follow-up (>10 Years) After PCI and CABG.2016

    • Author(s)
      Takeshi Kimura.
    • Organizer
      TCTAP2016
    • Place of Presentation
      Seoul(大韓民国)
    • Year and Date
      2016-04-26
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] MiR30-GALNTs axis-mediated O-glycosylation plays an important role in the increased secretion of unprocessed pro-brain natriuretic peptide by failing heart.2016

    • Author(s)
      Yasuaki Nakagawa, Toshio Nishikimi, Koichiro Kuwahara, Kazuwa Nakao and Takeshi Kimura.
    • Organizer
      KEYSTONE SYMPOSIA, Heart failure: Genetics, Genomics and Epigenetics (Z1)
    • Place of Presentation
      Snowbird, Utah(アメリカ合衆国)
    • Year and Date
      2016-04-03
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] MicroRNA-33 promotes cardiac fibrosis by maintaining cellular lipid homeostasis.2016

    • Author(s)
      Masataka Nishiga, Takahiro Horie, Yasuhide Kuwabara, Osamu Baba, Tetsushi Nakao, Tomohiro Nishino, Daihiko Hakuno, Yasuhiro Nakashima, Koji Hasegawa, Toru Kita, Takeshi Kimura, Koh Ono.
    • Organizer
      KEYSTONE SYMPOSIA, Heart failure: Genetics, Genomics and Epigenetics (Z1)
    • Place of Presentation
      Snowbird, Utah(アメリカ合衆国)
    • Year and Date
      2016-04-03
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Real-world Feasibility of Noninvasive Fractional Flow Reserve Derived from Computed Tomography (Real-FFRCT) Study.2016

    • Author(s)
      Tetsuma Kawaji, Hiroki Shiomi, Takeshi Morimoto, Charles A. Taylor, Takeshi Kimura.
    • Organizer
      American College of Cardiology(ACC)2016:65th Annual Scientific Session & Expo
    • Place of Presentation
      Chicago(アメリカ合衆国)
    • Year and Date
      2016-04-02
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Remarks] 京都大学循環器内科

    • URL

      http://kyoto-u-cardio.jp/

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
  • [Patent(Industrial Property Rights)] miR-33bノックインマウスによる非アルコール性脂肪肝炎モデル2017

    • Inventor(s)
      尾野 亘、堀江貴裕、西野共達
    • Industrial Property Rights Holder
      尾野 亘、堀江貴裕、西野共達
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2017-059580
    • Filing Date
      2017
    • Related Report
      2017 Annual Research Report
    • Overseas

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Published: 2016-04-21   Modified: 2020-03-30  

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