Analysis of the mechanisms of incretin secretion: similarities or differences of GIP and GLP-1 secretion

• Project/Area Number: 16H05326
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Metabolomics
• Research Institution: Kyoto University
• Principal Investigator: Inagaki Nobuya 京都大学, 医学研究科, 教授 (30241954)
• Co-Investigator(Kenkyū-buntansha): 原田 範雄 京都大学, 医学研究科, 講師 (50530169) ; 林 良敬 名古屋大学, 環境医学研究所, 准教授 (80420363) ; 山根 俊介 京都大学, 医学研究科, 助教 (90582156)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000); Fiscal Year 2018: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2017: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2016: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
• Keywords: インクレチン分泌 / インクレチン / GIP / GLP-1 / K細胞 / L細胞 / Incretin

Outline of Final Research Achievements

We examined FABP5 localization in K-cells before and after oral fat
intake using electron microscopy and confocal microscopy.FABP5 was present both in the nucleus and in the cytoplasm of K-cells before loading. In contrast, 60 minutes after fat loading, the intranuclear localization has disappeared. The expression of Regulator of G protein signaling 4(RGS4) was found to be elevated in the K cells of FABP5-deficient mouse. We clarified that both GPR120 and GPR40 are involved in GIP secretion after fat intake. It is suggested that GPR40 expressed in K-cells directly sense LCFA, and in contrast, GPR120 expressed in I-cells indirectly regulates GIP secretion in the presence of bile via CCK secretion.We also obtained results suggesting that carbonic anhydrase 8 (Car8), which shows high expression in L-cells, negatively regulates GLP-1 secretion in response to fatty acid stimulation.

Academic Significance and Societal Importance of the Research Achievements

肥満・2型糖尿病患者の数は増加の一途をたどっており、全世界的に重要な健康問題であるが、有効かつ安全性の高い治療法は未だ確立されていないのが現状である。本研究で注目しているインクレチンはその治療標的として大変有望であり、GIP制御に関わる重要な分子としてFABP5に、GLP-1分泌制御に関与するものとしてCar8に着目し、作用機構の解明に着手している。本研究の結果、薬剤によるFABP5、Car8の制御を介してインクレチン分泌制御が可能となれば、糖尿病・肥満症の新たな治療法の開発、創薬につながることが期待され研究の意義は大きい。

Research Products

• [Journal Article] Sphingosine kinase 1-interacting protein is a dual regulator of insulin and incretin secretion (2019)
  • Author(s): Liu Y, Harashima SI, Wang Y, Suzuki K, Tokumoto S, Usui R, Tatsuoka H, Tanaka D, Yabe D, Harada N, Hayashi Y, Inagaki N.
  • Journal Title: FASEB J. Volume: 33 Issue: 5 Pages: 6239-6253
  • DOI: 10.1096/fj.201801783rr
  • Peer Reviewed / Open Access
• [Journal Article] Solid-phase extraction treatment is required for measurement of active glucagon-like peptide-1 by enzyme-linked immunosorbent assay kit affected by heterophilic antibodies. (2019)
  • Author(s): Hasegawa T, Komagata M, Hamasaki A, Harada N, Seino Y, Inagaki N
  • Journal Title: Journal of Clinical Investigation Volume: 10 Issue: 2 Pages: 302-308
  • DOI: 10.1111/jdi.12896
  • Peer Reviewed / Open Access
• [Journal Article] Medium-chain triglyceride diet stimulates less GIP secretion and suppresses body weight and fat mass gain compared with long-chain triglyceride diet. (2019)
  • Author(s): Murata Y, Harada N, Yamane S, Iwasaki K, Ikeguchi E, Kanemaru Y, Harada T, Sankoda A, Shimazu-Kuwahara S, Joo E, Poudyal H, Inagaki N.
  • Journal Title: Am J Physiol Endocrinol Metab. Volume: accept Pages: 0-0
  • Peer Reviewed
• [Journal Article] Free fatty acid receptor GPR120 and GPR40 are essential for oil-induced GIP secretion. (2019)
  • Author(s): Sankoda A, Harada N, Kato T, Iwasaki K, Yamane S, Ikeguchi E, Murata Y, Hirasawa A, Inagaki N.
  • Journal Title: J Diabetes Investig. Volume: accept Pages: 0-0
  • Peer Reviewed / Open Access
• [Journal Article] A Novel p.L145Q Mutation in the HNF1B Gene in a Case of Maturity-onset Diabetes of the Young Type 5 (MODY5) (2018)
  • Author(s): Kato T, Tanaka D, Muro S, Jambaljav B, Mori E, Yonemitsu S, Oki S, Inagaki N.
  • Journal Title: Internal Medicine Volume: 57 Issue: 14 Pages: 2035-2039
  • DOI: 10.2169/internalmedicine.9692-17
  • NAID: 130007404920
  • ISSN: 0918-2918, 1349-7235
  • Year and Date: 2018-07-15
  • Peer Reviewed / Open Access
• [Journal Article] Glucose-dependent insulinotropic polypeptide deficiency reduced fat accumulation and insulin resistance, but deteriorated bone loss in ovariectomized mice (2018)
  • Author(s): Shimazu-Kuwahara Satoko、Kanemaru Yoshinori、Harada Norio、Ikeguchi Eri、Ueda Yohei、Yamane Shunsuke、Murata Yuki、Yasoda Akihiro、Kieffer Timothy J、Inagaki Nobuya
  • Journal Title: Journal of Diabetes Investigation Volume: Epub Issue: 4 Pages: 0-0
  • DOI: 10.1111/jdi.12978
  • NAID: 120006708221
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Case 23-2018: A Man with Episodes of Confusion and Hypoglycemia. (2018)
  • Author(s): Murakami T, Yabe D, Inagaki N.
  • Journal Title: N Engl J Med. Volume: 379 Issue: 19 Pages: 1881-1882
  • DOI: 10.1056/nejmc1811310
  • Peer Reviewed / Open Access
• [Journal Article] Establishment of a method for in-vivo SPECT/CT imaging analysis of 111In-labeled exendin-4 pancreatic uptake in mice without the need for nephrectomy or a secondary probe. (2018)
  • Author(s): K. Hamamatsu, H. Fujimoto, N. Fujita, T. Murakami, H. Kimura, H. Saji, N. Inagaki
  • Journal Title: Nucl Med Biol. Volume: 64-65 Pages: 22-27
  • DOI: 10.1016/j.nucmedbio.2018.06.002
  • Peer Reviewed
• [Journal Article] Transcriptional factor Pdx1 is involved in age-related GIP hypersecretion in mice. (2018)
  • Author(s): Ikeguchi E, Harada N, Kanemaru Y, Sankoda A, Yamane S, Iwasaki K, Imajo M, Murata Y, Suzuki K, Joo E, Inagaki N.
  • Journal Title: Am J Physiol Gastrointest Liver Physiol. Volume: 315 Issue: 2 Pages: 272-272
  • DOI: 10.1152/ajpgi.00054.2018
  • Peer Reviewed
• [Journal Article] Live imaging analysis of the growth plate in a murine long bone explanted culture system (2018)
  • Author(s): Hirota Keisho、Yasoda Akihiro、Kanai Yugo、Ueda Yohei、Yamauchi Ichiro、Yamashita Takafumi、Sakane Yoriko、Fujii Toshihito、Inagaki Nobuya
  • Journal Title: Scientific Reports Volume: 8 Issue: 1 Pages: 1-9
  • DOI: 10.1038/s41598-018-28742-x
  • NAID: 120006502590
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Dietary habits associated with reduced insulin resistance: The Nagahama Study. (2018)
  • Author(s): Ikeda K, Sato T, Nakayama T, Tanaka D, Nagashima K, Mano F, Joo E, Fujimoto S, Takahashi Y, Kosugi S, Sekine A, Tabara Y, Matsuda F, Inagaki N; Nagahama Study Group.
  • Journal Title: Diabetes Res Clin Pract Volume: In press
  • Peer Reviewed
• [Journal Article] Cross-cultural comparison of predictors for self-care behaviors in patients with type 2 diabetes. (2018)
  • Author(s): Ikeda K, Fujimoto S, Morling B, Ayano-Takahara S, Harashima SI, Uchida Y, Inagaki N.
  • Journal Title: J Diabetes Investig Volume: In press Issue: 5 Pages: 1212-1215
  • DOI: 10.1111/jdi.12822
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Glucose-dependent insulinotropic polypeptide is required for moderate high fat diet, but not high carbohydrate diet-induced weight gain. (2018)
  • Author(s): Maekawa R, Ogata H, Murase M, Harada N, Suzuki K, Joo E, Sankoda A, Iida A, Izumoto T, Tsunekawa S, Hamada Y, Oiso Y, Inagaki N, Arima H, Hayashi Y, Seino Y.
  • Journal Title: Am J Physiol Endocrinol Metab. Volume: 6 Issue: 6 Pages: 111-112
  • DOI: 10.1152/ajpendo.00352.2017
  • Peer Reviewed / Open Access
• [Journal Article] Prevalence of Cardiovascular Disease and Its Risk Factors in Primary Aldosteronism: A Multicenter Study in Japan. (2018)
  • Author(s): Ohno, Y., Sone, M., Inagaki, N., Yamasaki, T., Ogawa, O., Takeda, Y., Kurihara, I., Itoh, H., Umakoshi, H., Tsuiki, M., et al.
  • Journal Title: Hypertension Volume: 71 Issue: 3 Pages: 530-537
  • DOI: 10.1161/hypertensionaha.117.10263
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Evaluation of 18F-labeled exendin(9-39) derivatives targeting glucagon-like peptide-1 receptor for pancreatic β-cell imaging. (2018)
  • Author(s): Kimura H, Ogawa Y, Fujimoto H, Mukai E, Kawashima H, Arimitsu K, Toyoda K, Fujita N, Yagi Y, Hamamatsu K, Murakami T, Murakami A, Ono M, Nakamoto Y, Togashi K, Inagaki N, Saji H.
  • Journal Title: Bioorganic & Medicinal Chemistry Volume: 26 Issue: 2 Pages: 463-469
  • DOI: 10.1016/j.bmc.2017.12.007
  • Peer Reviewed
• [Journal Article] Long-term efficacy and safety of canagliflozin in combination with insulin in Japanese patients with type 2 diabetes mellitus. (2018)
  • Author(s): Inagaki N, Harashima S, Kaku K, Kondo K, Maruyama N, Otsuka M, Kawaguchi Y, Iijima H.
  • Journal Title: Diabetes Obes Metab Volume: 20(4) Issue: 4 Pages: 812-820
  • DOI: 10.1111/dom.13152
  • NAID: 120006425875
  • Peer Reviewed
• [Journal Article] Effects of three major amino acids found inJapanese broth on glucose metabolism and gastric emptying. (2018)
  • Author(s): Mano F, Ikeda K, Joo E, Yamane S, Harada N, Inagaki N.
  • Journal Title: Nutrition Volume: 46 Pages: 153-158
  • DOI: 10.1016/j.nut.2017.08.007
  • Peer Reviewed
• [Journal Article] Significance of dopamine D1 receptor signalling for steroidogenic differentiation of human induced pluripotent stem cells. (2017)
  • Author(s): Matsuo K, Sone M, Honda-Kohmo K, Toyohara T, Sonoyama T, Taura D, Kojima K, Fukuda Y, Ohno Y, Inoue M, Ohta A, Osafune K, Nakao K, Inagaki N.
  • Journal Title: Sci Rep. Volume: Nov 9;7(1) Issue: 1 Pages: 15120-15120
  • DOI: 10.1038/s41598-017-15485-4
  • Peer Reviewed / Open Access
• [Journal Article] Glucose-lowering effects and safety of DS-8500a, a G protein-coupled receptor 119 agonist, in Japanese patients with type 2 diabetes: results of a randomized, double-blind, placebo-controlled, parallel-group, multicenter, phase II study. (2017)
  • Author(s): Inagaki N, Chou HS, Tsukiyama S, Washio T, Shiosakai K, Nakatsuka Y, Taguchi T.
  • Journal Title: BMJ Open Diabetes Res Care Volume: 5(1) Issue: 1 Pages: e000424-e000424
  • DOI: 10.1136/bmjdrc-2017-000424
  • Peer Reviewed / Open Access
• [Journal Article] Distribution and hormonal characterization of primary murine L cells throughout the gastrointestinal tract (2017)
  • Author(s): Suzuki Kazuyo、Iwasaki Kanako、Murata Yuki、Harada Norio、Yamane Shunsuke、Hamasaki Akihiro、Shibue Kimitaka、Joo Erina、Sankoda Akiko、Fujiwara Yuta、Hayashi Yoshitaka、Inagaki Nobuya
  • Journal Title: J Diabetes Investig Volume: 9 Issue: 1 Pages: 25-32
  • DOI: 10.1111/jdi.12681
  • NAID: 120006376021
  • Peer Reviewed / Open Access
• [Journal Article] Circulating osteocrin stimulates bone growth by limiting C-type natriuretic peptide clearance. (2017)
  • Author(s): Kanai Y, Yasoda A, Mori KP, Watanabe-Takano H, Nagai-Okatani C, Yamashita Y, Hirota K, Ueda Y, Yamauchi I, Kondo E, Yamanaka S, Sakane Y, Nakao K, Fujii T, Yokoi H, Minamino N, Mukoyama M, Mochizuki N, Inagaki N.
  • Journal Title: Journal of Clinical Investigation Volume: 127 Issue: 11 Pages: 4136-4147
  • DOI: 10.1172/jci94912
  • Peer Reviewed / Open Access
• [Journal Article] Beta-cell replacement strategies for diabetes (2017)
  • Author(s): Kieffer Timothy J、Woltjen Knut、Osafune Kenji、Yabe Daisuke、Inagaki Nobuya
  • Journal Title: Journal of Diabetes Investigation Volume: 9 Issue: 3 Pages: 457-463
  • DOI: 10.1111/jdi.12758
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Identification of a small molecule that facilitates the differentiation of human iPSCs/ESCs and mouse embryonic pancreatic explants into pancreatic endocrine cells (2017)
  • Author(s): Kondo Yasushi、Toyoda Taro、Ito Ryo、Funato Michinori、Hosokawa Yoshiya、Matsui Satoshi、Sudo Tomomi、Nakamura Masahiro、Okada Chihiro、Zhuang Xiaotong、Watanabe Akira、Ohta Akira、Inagaki Nobuya、Osafune Kenji
  • Journal Title: Diabetologia Volume: 60 Issue: 8 Pages: 1454-1466
  • DOI: 10.1007/s00125-017-4302-7
  • Peer Reviewed
• [Journal Article] Long chain free fatty acid receptor GPR120 mediates oil-induced GIP secretion through CCK in male mice. (2017)
  • Author(s): 19.Sankoda A, Harada N, Iwasaki K, Yamane S, Murata Y, Shibue K, Thewjitcharoen Y, Suzuki K, Harada T, Kanemaru Y, Shimazu-Kuwahara S, Hirasawa A, Inagaki N.
  • Journal Title: Endocrinology. Volume: In press Issue: 5 Pages: 0-0
  • DOI: 10.1210/en.2017-00090
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Sphingosine kinase 1-interacting protein is a novel regulator of glucose-stimulated insulin secretion. (2017)
  • Author(s): Wang Y, Harashima SI, Liu Y, Usui R, Inagaki N.
  • Journal Title: Sci Rep. Volume: 10 Issue: 1 Pages: 779-779
  • DOI: 10.1038/s41598-017-00900-7
  • NAID: 120006305887
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Attenuated secretion of glucose-dependent insulinotropic polypeptide (GIP) does not alleviate hyperphagic obesity and insulin resistance in ob/ob mice. (2017)
  • Author(s): Shimazu-Kuwahara S, Harada N, Yamane S, Joo E, Sankoda A, Kieffer TJ, Inagaki N.
  • Journal Title: Mol Metab. Volume: 19 Issue: 3 Pages: 288-288
  • DOI: 10.1016/j.molmet.2017.01.006
  • NAID: 120005997778
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Myotonic dystrophy type 1 patient-derived iPSCs for the investigation of CTG repeat instability. (2017)
  • Author(s): Ueki J, Nakamori M, Nakamura M, Nishikawa M, Yoshida Y, Tanaka A, Morizane A, Kamon M, Araki T, Takahashi MP, Watanabe A, Inagaki N, Sakurai H.
  • Journal Title: Sci Rep. Volume: 13 Issue: 1 Pages: 42522-42522
  • DOI: 10.1038/srep42522
  • Peer Reviewed / Open Access
• [Journal Article] Inhibition of Gastric Inhibitory Polypeptide Receptor Signaling in Adipose Tissue Reduces Insulin Resistance and Hepatic Steatosis in High-Fat Diet-Fed Mice. (2017)
  • Author(s): Joo E, Harada N, Yamane S, Fukushima T, Taura D, Iwasaki K, Sankoda A, Shibue K, Harada T, Suzuki K, Hamasaki A, Inagaki N.
  • Journal Title: Diabetes. Volume: 66 Issue: 4 Pages: 868-868
  • DOI: 10.2337/db16-0758
  • NAID: 40021434294
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Epidemiology, clinical characteristics, and genetic etiology of neonatal diabetes in Japan. (2017)
  • Author(s): Nagashima K, Tanaka D, Inagaki N.
  • Journal Title: Pediatr Int. Volume: 59 Issue: 2 Pages: 129-129
  • DOI: 10.1111/ped.13199
• [Journal Article] Ubc13 haploinsufficiency protects against age-related insulin resistance and high-fat diet-induced obesity. (2016)
  • Author(s): Joo E, Fukushima T, Harada N, Reed JC, Matsuzawa SI, Inagaki N.
  • Journal Title: Sci Rep. Volume: 31 Issue: 1 Pages: 35983-35983
  • DOI: 10.1038/srep35983
  • NAID: 120005867104
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] C-type natriuretic peptide restores impaired skeletal growth in a murine model of glucocorticoid-induced growth retardation. (2016)
  • Author(s): Ueda Y, Yasoda A, Yamashita Y, Kanai Y, Hirota K, Yamauchi I, Kondo E, Sakane Y, Yamanaka S, Nakao K, Fujii T, Inagaki N.
  • Journal Title: Bone. Volume: 92 Pages: 157-157
  • DOI: 10.1016/j.bone.2016.08.026
  • Peer Reviewed
• [Journal Article] Mechanisms of fat-induced gastric inhibitory polypeptide/glucose-dependent insulinotropic polypeptide secretion from K cells. (2016)
  • Author(s): Yamane S, Harada N, Inagaki N.
  • Journal Title: J Diabetes Investig. Volume: 7 Issue: S1 Pages: 20-20
  • DOI: 10.1111/jdi.12467
  • NAID: 120005770746
  • Peer Reviewed / Open Access
• [Journal Article] Src regulates insulin secretion and glucose metabolism by influencing subcellular localization of glucokinase in pancreatic β-cells. (2016)
  • Author(s): Sato H, Nagashima K, Ogura M, Sato Y, Tahara Y, Ogura K, Yamano G, Sugizaki K, Fujita N, Tatsuoka H, Usui R, Mukai E, Fujimoto S, Inagaki N.
  • Journal Title: Journal of Diabetes Investigation Volume: 7 Issue: 2 Pages: 171-178
  • DOI: 10.1111/jdi.12407
  • NAID: 120005770743
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] インクレチンを介する臓器連関 (2018)
  • Author(s): 稲垣 暢也, 山根 俊介, 原田 範雄.
  • Organizer: 日本内分泌学会学術総会
  • Invited
• [Presentation] 転写因子Pancreatic duodenal homeobox-1(Pdx1)は加齢に伴うGIP分泌亢進に関与する (2018)
  • Author(s): 池口 絵理, 原田 範雄, 金丸 良徳, 三小田 亜希子, 山根 俊介, 岩﨑 可南子, 今城 正道, 村田 由貴, 鈴木 和代, 城尾 恵里奈, 稲垣 暢也.
  • Organizer: 第31回日本糖尿病・肥満動物学会学術集会
• [Presentation] インクレチンを介する臓器連関 (2017)
  • Author(s): 稲垣暢也, 山根俊介, 原田範雄.
  • Organizer: 第91回日本内分泌学会学術集会
• [Presentation] Glucose-dependent insulinotropic polypeptide (GIP) deficiency improves obesity but worsens bone loss in ovariectomised mice (2017)
  • Author(s): Kanemaru Y, Harada N, Kuwahara-Shimazu S, Ueda Y, Yamane S, Murata Y, Yasoda A, Kieffer TJ, Inagaki N.
  • Organizer: 53rd EASD Annual Meeting
  • Int'l Joint Research
• [Presentation] Role of gastric inhibitory polypeptide (GIP) in high fat diet-induced obesity and insulin resistance. (2017)
  • Author(s): Harada N, Yamane S, Inagaki N.
  • Organizer: Asia Islet Biology and Incretin Symposium
  • Int'l Joint Research
• [Presentation] Long chain free fatty acid receptor GPR120 mediates oil-induced GIP secretion through CCK in mice. (2017)
  • Author(s): Sankoda A, Harada N, Iwasaki K, Yamane S, Murata Y, Shibue K, Thewjitcharoen Y, Suzuki K, Harada T, Kanemaru Y, Shimazu-Kuwahara S, Hirasawa A, Inagaki N.
  • Organizer: Asia Islet Biology and Incretin Symposium
  • Int'l Joint Research
• [Presentation] 卵巣摘出マウスにおけるGIP分泌欠損は体重増加を抑制するが骨量を減少させる (2017)
  • Author(s): 金丸 良徳, 原田 範雄, 桑原 智子, 植田 洋平, 山根 俊介, 村田 由貴, 八十田 明宏, 稲垣 暢也.
  • Organizer: 第32回日本糖尿病合併症学会年次学術集会
• [Presentation] 長鎖脂肪酸受容体GPR120とGPR40は異なる機序で脂肪摂取時のGIP分泌に関与する (2017)
  • Author(s): 三小田 亜希子, 原田 範雄, 岩﨑 可南子, 山根 俊介, 村田 由貴, 金丸 良徳, 鈴木 和代, 渋江 公尊, 原田 貴成, 城尾 恵里奈, 平澤 明, 稲垣 暢也.
  • Organizer: 第60回日本糖尿病学会年次学術集会
• [Presentation] 過食肥満下におけるインクレチンGIPの生体内への影響について (2017)
  • Author(s): 桑原 智子, 原田 範雄, 金丸 良徳, 山根 俊介, 村田 由貴, 三小田 亜希子, 岩崎 可南子, 城尾 恵里奈, 渋江 公尊, 原田 貴成, 池口 絵理, 藤原 雄太, 稲垣 暢也.
  • Organizer: 第60回日本糖尿病学会年次学術集会
• [Presentation] 脂肪酸結合タンパク5(FABP5)の腸管内分泌K細胞における局在に関する検討 (2017)
  • Author(s): 池口 絵理, 渋江 公尊, Thewjitcharoen Yotsapon, 山根 俊介, 原田 範雄, 原田 貴成, 藤原 雄太, 鈴木 和代, 大和田 祐二, 稲垣 暢也.
  • Organizer: 第60回日本糖尿病学会年次学術集会
• [Presentation] 世界の健康に貢献する日本食の科学的・多面的検証 (2016)
  • Author(s): 稲垣暢也, 池田香織
  • Organizer: 日本農芸化学会創立100周年に向けたシンポジウム
  • Place of Presentation: 京都
  • Year and Date: 2016-10-24
  • Int'l Joint Research / Invited
• [Book] 栄養素に対する腸管内分泌細胞からのインクレチン分泌. 糖尿病. 第61巻第3号 (2018)
  • Author(s): 原田 範雄, 稲垣 暢也.
  • Total Pages: 3
  • Publisher: 日本糖尿病学会
• [Book] 【消化器疾患と代謝異常を考える】 《消化管疾患と代謝異常》 消化管ホルモンと栄養代謝. Modern Physician, 38巻2号 (2018)
  • Author(s): 原田 範雄, 稲垣 暢也.
  • Total Pages: 7
  • Publisher: 新興医学出版社
• [Book] 【激増する糖尿病の診療最前線】 糖尿病治療薬 DPP-4阻害薬. 臨牀と研究, 95巻1号 (2018)
  • Author(s): 原田 範雄, 稲垣 暢也.
  • Total Pages: 5
  • Publisher: 大道学館
• [Book] 腸管内分泌細胞研究の進化と展望】脂肪摂取時のインクレチン分泌について. Islet equality. Vol.6 No.1. (2017)
  • Author(s): 原田 範雄, 稲垣 暢也.
  • Total Pages: 4
  • Publisher: メディカルビュー社