Novel screenings for unmet medical needs with innovative new natural product derived compounds
| Project/Area Number |
16H05346
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Infectious disease medicine
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| Research Institution | Tohoku University |
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Principal Investigator |
Kodama Eiichi 東北大学, 災害科学国際研究所, 教授 (50271151)
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| Co-Investigator(Kenkyū-buntansha) |
大島 吉輝 東北大学, 医学系研究科, 特任教授(客員) (00111302)
浅井 禎吾 東京大学, 大学院総合文化研究科, 准教授 (60572310)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2018: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2017: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2016: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
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| Keywords | 感染症 / ウイルス / 薬学 / 化学合成 / 天然物 |
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| Outline of Final Research Achievements |
In the project, we have successfully established unique and divergent chemical libraries with innovative natural products under up-regulation of the synthetic enzymes and/or pathways of plants or microbes by various anti-silencing agents. Further chemical modifications have been applied to the isolated products and determined chemical structures with nuclear magnetic resonance analysis. In addition, we have also established several novel screening methods for unmet medical needs. Some compounds show new biological activities, such as anti-osteoporosis, anti-cancers associated with virus infections, and anti-viruses. These valuable achievements were published and presented in scientific meetings elsewhere. Our innovative libraries and novel screening systems based on chemical biology may contribute to rational drug designs and developments.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究により、近年、枯渇しつつある天然物由来新規化合物の効率的な取得を可能としただけでなく、化学修飾を加えることで飛躍的に多様性を有するライブラリーを既存法と比べ簡便かつ短時間に構築できることを明らかとした。希少疾患も含めたアンメットメディカルニーズに対応する新規化合物評価系を複数構築し、骨粗しょう症とウイルス発がんを抑制しうる天然物由来のヒットを見出したことから、我々のライブラリーの有用性を確認した。社会的には、少子化・高齢化に伴う疾患の複雑性に対応する薬剤開発の一助となったと思われる。
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Report
(4 results)
Research Products
(23 results)
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[Journal Article] Identification of human immunodeficiency virus type-1 Gag-TSG101 interaction inhibitors by high-throughput screening2018
Author(s)
Lowela Siarot, Nopporn Chutiwitoonchai, Hirotaka Sato, Hao Chang, Hironori Sato, Masayuki,Fujino,Tsutomu Murakami,Toshihiro Aono, Eiichi Kodama, Kazumichi Kuroda, Masami Takei, Yoko Aida
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Journal Title
Biochemical and Biophysical Research Communications
Volume: 503
Issue: 4
Pages: 2970-2976
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] A Cinnamon-Derived Procyanidin.Compound Displays Anti-HIV-1 Activity by Blocking Heparan Sulfate- and Co-Receptor- Binding Sites on gp120 and Reverses T Cell Exhaustion via Impeding Tim-3 and PD-1 Upregulation2016
Author(s)
Connell BJ, Chang SY, Prakash E, Yousfi R, Mohan V, Posch W, Wilflingseder D, Moog C, Kodama EN, Clayette P, Lortat-Jacob H.
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Journal Title
PLoS One.
Volume: 2
Issue: 10
Pages: e0165386-e0165386
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] A Novel Peptide Derived from the Fusion Protein Heptad Repeat Inhibits Replication of Subacute Sclerosing Panencephalitis Virus In Vitro and In Vivo.2016
Author(s)
Watanabe M, Hashimoto K, Abe Y, Kodama EN, Nabika R, Oishi S, Ohara S, Sato M,Kawasaki Y, Fujii N, Hosoya M.
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Journal Title
PLoS One.
Volume: 11
Issue: 9
Pages: e0162823-e0162823
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] Characterization of novel HIV-1 inhibitorstargeting Gag-TSG101 interaction.2018
Author(s)
Siarot Lowela, Chutiwitoonchai Nopporn, 佐藤洋隆, Chang Hao, 小谷治, 横山勝, 佐藤裕徳, 藤野真之, 村上努, 近藤恭光, 本田香り, 長田裕之, 上田一樹, 伊藤嘉浩, 青野俊裕, 児玉栄一, 黒田和道, 武井正美, 間陽子
Organizer
第32回日本エイズ学会
Related Report
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