Dissecting the prefrontal cortex dysfunction and its recovery in autism spectrum disorder.
Project/Area Number |
16H05377
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Psychiatric science
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Research Institution | Nara Medical University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
紀本 創兵 奈良県立医科大学, 医学部, 講師 (00405391)
芳野 浩樹 奈良県立医科大学, 医学部, 准教授 (10347560)
太田 豊作 奈良県立医科大学, 医学部, 学内講師 (10553646)
安野 史彦 国立研究開発法人国立長寿医療研究センター, 病院, 医長 (60373388)
松田 康裕 奈良県立医科大学, 医学部, 助教 (70445063)
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Project Period (FY) |
2016-04-01 – 2020-03-31
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Project Status |
Completed (Fiscal Year 2019)
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Budget Amount *help |
¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2019: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2018: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
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Keywords | 自閉スペクトラム症 / 前頭前野 / 小児期体験 / リハビリテーション / 社会性 / 髄鞘形成 / 社会的経験 / MRI / 認知リハビリテーション / ミエリン / 自閉症 / 前頭前野機能 / 恐怖記憶 |
Outline of Final Research Achievements |
The main purpose of this study was to clarify the structural and functional abnormalities of the prefrontal cortex in adult autism spectrum disorder (ASD) and to establish a method to improve the prefrontal cortex abnormalities. In this study, we considered that childhood experiences of ASD individuals are different from those of typically developed individuals, and conducted research on the impact of childhood experiences of ASD individuals on prefrontal pathology in mice and humans. Mouse studies reveal that juvenile experience activates microglia in the cerebral cortex and environmental intervention can improve prefrontal myelination defects, demonstrating the importance of childhood experiences. From human studies, we have been able to clarify multiple ASD biomarkers and brain circuits that regulate ASD symptoms by using blood and cutting-edge neuroimaging techniques.
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Academic Significance and Societal Importance of the Research Achievements |
自閉スペクトラム症(ASD)は社会的な問題となっているものの、決定的な治療法はみつかっておらず、その開発は喫緊の課題である。本研究では従来のようにASD病態を定型発達者と比較することで明らかにするのではなく、その小児期体験に着目することで新規知見を得るよう試みた。不良な小児期体験がこれまでに報告されたASD者で認められる諸症状の一部を引き起こすことが明らかになり、ASD者の小児期体験を調整することによるASD症状の軽減が得られる可能性が示された。ASDの諸症状はペアレントトレーニングやソーシャルスキルトレーニングなどの早期介入によって軽減されるが、本研究結果はそれを支持するものである。
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Report
(5 results)
Research Products
(25 results)
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[Journal Article] Microstructural Anomalies Evaluated by Neurite Orientation Dispersion and Density Imaging Are Related to Deficits in Facial Emotional Recognition via Perceptual-Binding Difficulties in Autism Spectrum Disorder2020
Author(s)
Fumihiko Yasuno 1 2 , Manabu Makinodan 1 , Masato Takahashi 1 , Kiwamu Matsuoka 1 , Hiroaki Yoshikawa 1 , Soichiro Kitamura 1 , Rio Ishida 1 , Naoko Kishimoto 1 , Toshiteru Miyasaka 3 , Kimihiko Kichikawa 3 , Toshifumi Kishimoto 1
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Journal Title
Autism Res
Volume: 13
Issue: 5
Pages: 729-740
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Delayed Prefrontal Hemodynamic Response Associated With Suicide Risk in Autism Spectrum Disorder2020
Author(s)
Ota T, Iida J, Okazaki K, Ishida R, Takahashi M, Okamura K, Yamamuro K, Kishimoto N, Kimoto S, Yasuda Y, Hashimoto R, Makinodan M, Kishimoto T.
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Journal Title
Psychiatry Res
Volume: 289
Pages: 112971-112971
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Increased dendritic orientationdispersion in the left occipital gyrus is associated with atypical visual processing in adults with autism spectrum disorder2020
Author(s)
1.Matsuoka K, Makinodan M*, Kitamura S, Takahashi M, Yoshikawa H, Yasuno F, Ishida R, Kishimoto N,Yasuda Y, Hashimoto R, Taoka T, Miyasaka T, Kichikawa K, Kishimoto T
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Journal Title
Cereb Cortex
Volume: in press
Related Report
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[Journal Article] The Self-Construal Scale: A Potential Tool for Predicting Subjective Well-Being of Individuals With Autism Spectrum Disorder2019
Author(s)
Sachie Kaneko 1 2 3 , Takahiro A Kato 1 , Manabu Makinodan 4 , Takashi Komori 4 , Rio Ishida 4 , Naoko Kishimoto 4 , Masato Takahashi 4 , Yuka Yasuda 4 5 6 , Ryota Hashimoto 6 7 , Hidemi Iwasaka 3 , Ayumi Tanaka 8 , Yukiko Uchida 2 , Shigenobu Kanba 1 , Toshifumi Kishimoto 4
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Journal Title
Autism Res
Volume: in press
Issue: 6
Pages: 947-958
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Multiple animal positioning system shows that socially-reared mice influence the social proximity of isolation-reared cagemates.2018
Author(s)
Endo N, Ujita W, Fujiwara T, Miyauchi H, Mishima H, Makino Y, Hashimoto L, Oyama, H, Makinodan M, Nishi M, Tohyama C, Kakeyama M*
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Journal Title
Communications Biology
Volume: 1
Issue: 1
Pages: 225-225
DOI
Related Report
Peer Reviewed / Open Access
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