Analysis of cleft palate mechanism using p53 gene-deficient consomic mice
Project/Area Number |
16H05539
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Surgical dentistry
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Research Institution | Niigata University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
大峡 淳 新潟大学, 医歯学系, 教授 (40266169)
児玉 泰光 新潟大学, 医歯学総合病院, 講師 (90419276)
|
Project Period (FY) |
2016-04-01 – 2020-03-31
|
Project Status |
Completed (Fiscal Year 2019)
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Budget Amount *help |
¥12,610,000 (Direct Cost: ¥9,700,000、Indirect Cost: ¥2,910,000)
Fiscal Year 2019: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2018: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2017: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2016: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
|
Keywords | 口蓋裂 / p53 / 口唇口蓋裂 / p53遺伝子 / ノックアウトマウス / 感受性遺伝子 / 放射線照射 / コンソミックマウス |
Outline of Final Research Achievements |
CL / Fr strain mice, which are inbred mice, include mice having both a primary cleft palate and a secondary cleft palate. This time, using CL / Fr strain mice, we analyzed whether there is a difference at the molecular level between primary cleft palate and secondary cleft palate. No change was observed in those signals in the secondary cleft palate region.
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Academic Significance and Societal Importance of the Research Achievements |
口蓋裂は、一次口蓋と二次口蓋の間の口蓋裂 (primary cleft palate)と、二次口蓋における口蓋裂(secondary cleft palate)に大別され、primary cleft palateとsecondary cleft palateが同じメカニズムで生じているかは不明である。本研究の結果から、primary cleft palateとsecondary cleft palateは、別々のメカニズムでひき起こる可能性があることが示唆された。
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Report
(5 results)
Research Products
(1 results)