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Analysis of cleft palate mechanism using p53 gene-deficient consomic mice

Research Project

Project/Area Number 16H05539
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Surgical dentistry
Research InstitutionNiigata University

Principal Investigator

Takagi Ritsuo  新潟大学, 医歯学系, 教授 (20143795)

Co-Investigator(Kenkyū-buntansha) 大峡 淳  新潟大学, 医歯学系, 教授 (40266169)
児玉 泰光  新潟大学, 医歯学総合病院, 講師 (90419276)
Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥12,610,000 (Direct Cost: ¥9,700,000、Indirect Cost: ¥2,910,000)
Fiscal Year 2019: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2018: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2017: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2016: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Keywords口蓋裂 / p53 / 口唇口蓋裂 / p53遺伝子 / ノックアウトマウス / 感受性遺伝子 / 放射線照射 / コンソミックマウス
Outline of Final Research Achievements

CL / Fr strain mice, which are inbred mice, include mice having both a primary cleft palate and a secondary cleft palate. This time, using CL / Fr strain mice, we analyzed whether there is a difference at the molecular level between primary cleft palate and secondary cleft palate. No change was observed in those signals in the secondary cleft palate region.

Academic Significance and Societal Importance of the Research Achievements

口蓋裂は、一次口蓋と二次口蓋の間の口蓋裂 (primary cleft palate)と、二次口蓋における口蓋裂(secondary cleft palate)に大別され、primary cleft palateとsecondary cleft palateが同じメカニズムで生じているかは不明である。本研究の結果から、primary cleft palateとsecondary cleft palateは、別々のメカニズムでひき起こる可能性があることが示唆された。

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • Research Products

    (1 results)

All 2020

All Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results,  Open Access: 1 results)

  • [Journal Article] Changes in signaling pathways in the palatal cleft in CL/Fr2020

    • Author(s)
      Yamada A, Nagai T, Kitamura A, Kawasaki M, Kawasaki K, Kodama Y, Maeda T, Ohazama A, Takagi R
    • Journal Title

      J Oral Maxillofac Surg Med Pathol

      Volume: in press

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research

URL: 

Published: 2016-04-21   Modified: 2021-02-19  

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