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Effect of Oral environment on hippocampal network in the erderly

Research Project

Project/Area Number 16H05560
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Social dentistry
Research InstitutionNagoya Women's University (2017-2019)
Seijoh University (2016)

Principal Investigator

Kubo kin-ya  名古屋女子大学, 健康科学部, 教授 (00329492)

Co-Investigator(Kenkyū-buntansha) 笹栗 健一  自治医科大学, 医学部, 講師 (10235286)
東 華岳  産業医科大学, 医学部, 教授 (20273146)
飯沼 光生  朝日大学, 歯学部, 教授 (70184364)
高橋 徹  郡山女子大学, 家政学部, 准教授 (80324292)
小野塚 実  神奈川歯科大学, 歯学部, 名誉教授 (90084780)
Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥14,690,000 (Direct Cost: ¥11,300,000、Indirect Cost: ¥3,390,000)
Fiscal Year 2019: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2018: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2017: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2016: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Keywords口腔環境 / デフォルドモードネットワーク / 神経心理学的検査 / 磁気共鳴画像法 / 脳内ネットワーク / 神経心理的検査 / デフォルトモードネットワーク / 老年歯科医学 / 歯学 / 歯 / 認知機能 / 海馬
Outline of Final Research Achievements

We examined the relationship between number of teeth and default mode network activity and connectivity, and score of social psychological test, e.g., MMSE (Mini-Mental State Examination). Default mode network activity and connectivity, and score of MMSE in the elderly with ≦9 teeth tends to decrease than those of the elderly with ≧10 teeth, however, no statistical significant was seen. Another network activity and connectivity in the central nervous system tends to decrease in the elderly with decrease in teeth. There is a possibility that another oral environment other than tooth number, e.g., swallowing function, involves in default mode network and connectivity, and score of MMSE.

Academic Significance and Societal Importance of the Research Achievements

本研究は記憶の中枢である海馬の萎縮など脳の不可逆的な変化に至る前の回復可能なステージにスポットをあて、脳内ネットワークの機能低下におよぼす口腔環境の影響を神経科学的に追跡調査し、口腔機能による認知症予防の可能性を検討したことに学術的意義がある。本研究により、回復可能な段階での認知症予防プログラムの開発が可能になり、認知症を大幅に減少させることができる可能性が生まれ、破綻が懸念される医療費の削減に大きく寄与することが期待できる。

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • Research Products

    (2 results)

All 2020 2019

All Journal Article (2 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 2 results,  Open Access: 1 results)

  • [Journal Article] Tooth loss early in life induces hippocampal morphology remodeling in senescence-accelerated mouse prone 8 (SAMP8) mice2020

    • Author(s)
      Masahisa Katano, Kyoko Kajimoto, Mitsuo Iinuma, Kagaku Azuma, Kin-ya Kubo
    • Journal Title

      Int J Med Sci

      Volume: 17(4) Issue: 4 Pages: 517-524

    • DOI

      10.7150/ijms.40241

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Vulnerability to stress in mouse offspring is ameliorated when pregnant dams are provided a chewing stick during prenatal stress.2019

    • Author(s)
      Kubo KY, Suzuki A, Iinuma M, Sato Y, Nagashio R, Ohta E, Azuma K.
    • Journal Title

      Arch Oral Biol

      Volume: 97 Pages: 150-155

    • DOI

      10.1016/j.archoralbio.2018.10.014

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research

URL: 

Published: 2016-04-21   Modified: 2021-02-19  

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