Establishment of early diagnostic markers for nasopharyngeal carcinoma and experimental verification through fieldwork in southern China
Project/Area Number |
16H05829
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 海外学術 |
Research Field |
Hygiene and public health
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Research Institution | Mie University |
Principal Investigator |
Murata Mariko 三重大学, 医学系研究科, 教授 (10171141)
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Co-Investigator(Kenkyū-buntansha) |
及川 伸二 三重大学, 医学系研究科, 准教授 (10277006)
翠川 薫 三重大学, 医学系研究科, リサーチアソシエイト (20393366)
馬 寧 鈴鹿医療科学大学, 医療科学研究科, 教授 (30263015)
平工 雄介 福井大学, 学術研究院医学系部門, 教授 (30324510)
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Project Period (FY) |
2016-04-01 – 2019-03-31
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Project Status |
Completed (Fiscal Year 2018)
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Budget Amount *help |
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2018: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2016: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
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Keywords | 上咽頭癌 / 中国南部 / Epstein-Barr ウィルス / DNA損傷 / DNAメチル化 / バイオマーカー / 早期診断マーカー / 癌 / スクリーニング / メチル化DNA |
Outline of Final Research Achievements |
Epstein-Barr virus-related nasopharyngeal carcinoma (NPC) is endemic in southern China. The purpose of this study is to explore early diagnostic markers for NPC, which can apply to fieldwork. We examined genetic/epigenetic aberrations, such as oxidative/nitrative DNA lesions, DNA methylation, and microRNA in NPC samples to elucidate carcinogenic mechanisms and to find biomarkers. We performed genome-wide analysis for promoter DNA hypermethylation, and found several candidate genes. We tried to measure DNA methylation rate in blood as an applicable sample in fieldwork. It is suggested that combination of DNA methylation rate and other marker may be more efficient for the screening.
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Academic Significance and Societal Importance of the Research Achievements |
上咽頭癌の発症機構として、炎症に由来する酸化・ニトロ化DNA損傷やエピゲノム異常が重要であり、診断マーカーとしての可能性を示したことは、全がんの25%を占める炎症関連発がんの予防や早期診断のための戦略に資する学術的意義がある。また、血液を試料としてバイオマーカーを探索したことは、リキッドバイオプシーとして診断や治療効果の判定への応用が期待される。
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Report
(4 results)
Research Products
(102 results)
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[Journal Article] Oxidative DNA damage induced by pirarubicin, an anthracycline anticancer agent, in the presence of copper(II).2018
Author(s)
Mizutani H, Nishimoto A, Hotta S, Ikemura K, Imai M, Miyazawa D, Ohta K, Ikeda Y, Maeda T, Yoshikawa M, Hiraku Y, Kawanishi S
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Journal Title
Anticancer Research
Volume: 38
Issue: 5
Pages: 2643-2648
DOI
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Peer Reviewed / Open Access
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[Journal Article] Pirarubicin, an Anthracycline Anticancer Agent, Induces Apoptosis Through Generation of Hydrogen Peroxide.2017
Author(s)
Mizutani H, Hotta S, Nishimoto A, Ikemura K, Miyazawa D, Ikeda Y, Maeda T, Yoshikawa M, Hiraku Y, Kawanishi S.
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Journal Title
Anticancer Res.
Volume: 37
Issue: 11
Pages: 6063-6069
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] APOE Genotype in the Ethnic Majority and Minority Groups of Laos and the Implications for Non-Communicable Diseases.2016
Author(s)
Midorikawa K, Soukaloun D, Akkhavong K, Southivong B, Rattanavong O, Sengkhygnavong V, Pyaluanglath A, Sayasithsena S, Nakamura S, Midorikawa Y, Murata M.
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Journal Title
PLoS One
Volume: 11
Issue: 5
Pages: 1-15
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Epigenetic inactivation of follistatin-like 1 mediates tumor immune evasion in nasopharyngeal carcinoma.2016
Author(s)
Zhou X, Xiao X, Huang T, Du C, Wang S, Mo Y, Ma N, Murata M, Li B, Wen W, Huang G, Zeng X, Zhang Z
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Journal Title
Oncotarget
Volume: 7
Issue: 13
Pages: 16433-16444
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Glutaredoxin 3 promotes nasopharyngeal carcinoma growth and metastasis via EGFR/Akt pathway and independent of ROS.2016
Author(s)
He F, Wei L, Luo W, Liao Z, Li B, Zhou X, Xiao X, You J, Chen Y, Zheng S, Li P, Murata M, Huang G, Zhang Z
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Journal Title
Oncotarget.
Volume: 7
Issue: 24
Pages: 37000-37012
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Exposure assessment and heart rate variability monitoring in workers handling titanium dioxide particles-a pilot study.2016
Author(s)
Ichihara S, Li W, Omura S, Fujitani Y, Liu Y, Wang Q, Hiraku Y, Hisanaga N, Wakai K, Ding X, Kobayashi T, Ichihara G.
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Journal Title
J. Nanopart. Res.
Volume: 18
Issue: 3
Pages: 52-52
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] RKCB, a tumor suppressor, is epigenetically inactivated in nasopharyngeal carcinoma2016
Author(s)
Weilin Zhao, Shumin Wang, Kaoru Midorikawa, Zhe Zhang, Yingxi Mo, Guangwu Huang, Ning Ma, Yusuke Hiraku, Shinji Oikawa, Kazuhiko Takeuchi, Mariko Murata.
Organizer
第75回日本癌学会総会
Place of Presentation
パシフィコ横浜(神奈川県横浜市)
Year and Date
2016-10-06
Related Report
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