Effects and Safety of Oral Mast Cells Stabilization Therapy in Early Dengue Patients: A Randomized, Placebo-Controlled Trial
| Project/Area Number |
16H05844
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 海外学術 |
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| Research Field |
Infectious disease medicine
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| Research Institution | Nagasaki University |
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Principal Investigator |
NGUYEN Huytien 長崎大学, 熱帯医学・グローバルヘルス研究科, 准教授 (20457526)
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| Co-Investigator(Kenkyū-buntansha) |
ローサボーン チャントラ 長崎大学, 熱帯医学研究所, 教授 (10640196)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000)
Fiscal Year 2018: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2017: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2016: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
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| Keywords | デング / 血漿漏出 / 超音波 / 診断 / アレルギー / Dengue / Clinical trial / Ultrasound / Mast cells / Allergy / Severity / ウィルス / 感染症 / 免疫学 / dengue / 微生物 |
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| Outline of Final Research Achievements |
We have already finished a systematic review to optimize a standardized ultrasound to measure the plasma leakage in dengue patients that is the main indicator of dengue severity. A clinical study has been conducted to assess the reproducibility of US in the assessment of gallbladder-wall thickness in addition to the volume of pleural effusion and ascites as a consequence of plasma leakage in dengue children. Our results showed that ultrasound values of plasma leakage were highly reproducible and showed a good intra- and inter-observer agreement between ultrasonic doctors.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究は、デング熱の診断とその重症度を予測する超音波検査の標準化手法を確立した。本手法は臨床医師の診断に役立つことが期待される。我々は既に本手法のパイロット試験を行った。臨床応用のためには更に臨床試験を繰り返す必要がある。
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Report
(4 results)
Research Products
(10 results)
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[Journal Article] Plasma cell-free DNA: a potential biomarker for early prediction of severe dengue2019
Author(s)
Phuong Nguyen Thi Ngoc、Manh Dao Huy、Dumre Shyam Prakash、Mizukami Shusaku、Weiss Lan Nguyen、Van Thuong Nguyen、Ha Tran Thi Ngoc、Phuc Le Hong、Van An Tran、Tieu Thuan Minh、Kamel Mohamed Gomaa、Morra Mostafa Ebraheem、Huong Vu Thi Que、Huy Nguyen Tien、Hirayama Kenji
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Journal Title
Annals of Clinical Microbiology and Antimicrobials
Volume: 18
Issue: 1
Pages: 1-6
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Definitions for Warning Signs and Signs of Severe Dengue According to The WHO 2009 Classification: Systematic Review of Literature2018
Author(s)
Morra ME, Altibi AM, Iqtadar S, Minh LHN, Elawady SS, Hallab A, Elshafay A, Omer OA, Iraqi A, Adhikari P, Labib JH, Elhusseiny KM, Elgebaly A, Yacoub S, Huong LTM, Hirayama K, Huy NT
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Journal Title
Reviews in Medical Virology
Volume: April
Issue: 4
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Post-dengue acute disseminated encephalomyelitis: A case report and meta-analysis2017
Author(s)
Kamel MG, Nam NT, Han NHB, El-Shabouny AE, Makram AM, Abd-Elhay FA, Dang TN, Hieu NLT, Huong VTQ, Tung TH, Hirayama K, Huy NT
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Journal Title
PLoS Negl Trop Dis
Volume: 11(6)
Issue: 6
Pages: e0005715-e0005715
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Presentation] Epidemiology, clinical characteristics, and sequelae of Zika infection. A systematic review and meta-analysis.2017
Author(s)
Huy NT, Giang HN, Alabd S, Ghozy S, Linh LK, Nguyen DPN, Anh TM, Dang NP, Turk T, Hassan M, AbdElsalam ES, Onyeudo O, Nasef S, Sassy A, Hadad HE, Aly S, Hirayama K
Organizer
Australasian Society for Infectious Diseases (ASID). Annual Scientific Meeting.
Place of Presentation
Blue Mountain, Sydney, Australia
Year and Date
2017-03-29
Related Report
Int'l Joint Research
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[Presentation] Drug discovery2016
Author(s)
Nguyen Tien Huy
Organizer
Seminar; invited by VN-UK Institute for Research & Executive Education, The University of Danang
Place of Presentation
The University of Danang, Da Nang, Vietnam
Year and Date
2016-10-03
Related Report
Invited
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