Effects and Safety of Oral Mast Cells Stabilization Therapy in Early Dengue Patients: A Randomized, Placebo-Controlled Trial

• Project/Area Number: 16H05844
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 海外学術
• Research Field: Infectious disease medicine
• Research Institution: Nagasaki University
• Principal Investigator: NGUYEN Huytien 長崎大学, 熱帯医学・グローバルヘルス研究科, 准教授 (20457526)
• Co-Investigator(Kenkyū-buntansha): ローサボーン チャントラ 長崎大学, 熱帯医学研究所, 教授 (10640196)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000); Fiscal Year 2018: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000); Fiscal Year 2017: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000); Fiscal Year 2016: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
• Keywords: デング / 血漿漏出 / 超音波 / 診断 / アレルギー / Dengue / Clinical trial / Ultrasound / Mast cells / Allergy / Severity / ウィルス / 感染症 / 免疫学 / dengue / 微生物

Outline of Final Research Achievements

We have already finished a systematic review to optimize a standardized ultrasound to measure the plasma leakage in dengue patients that is the main indicator of dengue severity. A clinical study has been conducted to assess the reproducibility of US in the assessment of gallbladder-wall thickness in addition to the volume of pleural effusion and ascites as a consequence of plasma leakage in dengue children. Our results showed that ultrasound values of plasma leakage were highly reproducible and showed a good intra- and inter-observer agreement between ultrasonic doctors.

Academic Significance and Societal Importance of the Research Achievements

本研究は、デング熱の診断とその重症度を予測する超音波検査の標準化手法を確立した。本手法は臨床医師の診断に役立つことが期待される。我々は既に本手法のパイロット試験を行った。臨床応用のためには更に臨床試験を繰り返す必要がある。

Research Products

• [Journal Article] Systematic review of spontaneous splenic rupture in dengue-infected patients (2019)
  • Author(s): Radwan Ibrahim、Magdy Khattab Mohamed、Mahmoud Abdalla Reda、Nghia Thai Le Ba、Y Mai Nhu、Trung Dinh The、Hirayama Kenji、Huy Nguyen Tien
  • Journal Title: Reviews in Medical Virology Volume: 29 Issue: 2
  • DOI: 10.1002/rmv.2029
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Plasma cell-free DNA: a potential biomarker for early prediction of severe dengue (2019)
  • Author(s): Phuong Nguyen Thi Ngoc、Manh Dao Huy、Dumre Shyam Prakash、Mizukami Shusaku、Weiss Lan Nguyen、Van Thuong Nguyen、Ha Tran Thi Ngoc、Phuc Le Hong、Van An Tran、Tieu Thuan Minh、Kamel Mohamed Gomaa、Morra Mostafa Ebraheem、Huong Vu Thi Que、Huy Nguyen Tien、Hirayama Kenji
  • Journal Title: Annals of Clinical Microbiology and Antimicrobials Volume: 18 Issue: 1 Pages: 1-6
  • DOI: 10.1186/s12941-019-0309-x
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Definitions for Warning Signs and Signs of Severe Dengue According to The WHO 2009 Classification: Systematic Review of Literature (2018)
  • Author(s): Morra ME, Altibi AM, Iqtadar S, Minh LHN, Elawady SS, Hallab A, Elshafay A, Omer OA, Iraqi A, Adhikari P, Labib JH, Elhusseiny KM, Elgebaly A, Yacoub S, Huong LTM, Hirayama K, Huy NT
  • Journal Title: Reviews in Medical Virology Volume: April Issue: 4
  • DOI: 10.1002/rmv.1979
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Association between dengue severity and plasma levels of dengue-specific IgE and chymase (2018)
  • Author(s): Inokuchi Miho、Dumre Shyam Prakash、Mizukami Shusaku、Tun Mya Myat Ngwe、Kamel Mohamed Gomaa、Manh Dao Huy、Phuc Le Hong、Van Thuong Nguyen、Van An Tran、Weiss Lan Nguyen、Turk Tarek、Dang Tran Ngoc、Huong Vu Thi Que、Morita Kouichi、Huy Nguyen Tien、Hirayama Kenji
  • Journal Title: Archives of Virology Volume: 163 Issue: 9 Pages: 2337-2347
  • DOI: 10.1007/s00705-018-3849-z
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Dengue hemophagocytic syndrome: A systematic review and meta‐analysis on epidemiology, clinical signs, outcomes, and risk factors (2018)
  • Author(s): Giang Hoang Thi Nam、Banno Keita、Minh Le Huu Nhat、Trinh Lam Tuyet、Loc Le Thai、Eltobgy Asmaa、Tai Luu Lam Thang、Khan Adnan、Tuan Nguyen Hoang、Reda Yaser、Samsom Maryan、Nam Nguyen Tran、Huy Nguyen Tien、Hirayama Kenji
  • Journal Title: Reviews in Medical Virology Volume: 28 Issue: 6
  • DOI: 10.1002/rmv.2005
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Post-dengue acute disseminated encephalomyelitis: A case report and meta-analysis (2017)
  • Author(s): Kamel MG, Nam NT, Han NHB, El-Shabouny AE, Makram AM, Abd-Elhay FA, Dang TN, Hieu NLT, Huong VTQ, Tung TH, Hirayama K, Huy NT
  • Journal Title: PLoS Negl Trop Dis Volume: 11(6) Issue: 6 Pages: e0005715-e0005715
  • DOI: 10.1371/journal.pntd.0005715
  • Peer Reviewed / Int'l Joint Research
• [Presentation] Epidemiology, clinical characteristics, and sequelae of Zika infection. A systematic review and meta-analysis. (2017)
  • Author(s): Huy NT, Giang HN, Alabd S, Ghozy S, Linh LK, Nguyen DPN, Anh TM, Dang NP, Turk T, Hassan M, AbdElsalam ES, Onyeudo O, Nasef S, Sassy A, Hadad HE, Aly S, Hirayama K
  • Organizer: Australasian Society for Infectious Diseases (ASID). Annual Scientific Meeting.
  • Place of Presentation: Blue Mountain, Sydney, Australia
  • Year and Date: 2017-03-29
  • Int'l Joint Research
• [Presentation] Starting a research and interpreting research results (2016)
  • Author(s): Nguyen Tien Huy
  • Organizer: Lecture invited by Hospital of Children of Ho Chi Minh City
  • Place of Presentation: Hospital of Children of Ho Chi Minh City, Ho Chi Minh City, Vietnam.
  • Year and Date: 2016-12-07
  • Invited
• [Presentation] Drug discovery (2016)
  • Author(s): Nguyen Tien Huy
  • Organizer: Seminar; invited by VN-UK Institute for Research & Executive Education, The University of Danang
  • Place of Presentation: The University of Danang, Da Nang, Vietnam
  • Year and Date: 2016-10-03
  • Invited
• [Presentation] How to find ideas and publish academic papers (2016)
  • Author(s): Nguyen Tien Huy
  • Organizer: Workshop at University of Medicine and Pharmacy, Ho Chi Minh City
  • Place of Presentation: University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam.
  • Year and Date: 2016-06-11
  • Invited