| Budget Amount *help |
¥25,870,000 (Direct Cost: ¥19,900,000、Indirect Cost: ¥5,970,000)
Fiscal Year 2019: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2018: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥14,950,000 (Direct Cost: ¥11,500,000、Indirect Cost: ¥3,450,000)
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| Outline of Final Research Achievements |
During metastasis, cancer cells migrate through various microstructures in the body, but the mechanical influence of these structures or the underlying mechanism have not been clarified. From our previous works, it was shown that microgroove structures can change the motility of various cells like breast cancer epithelial cells, referred to as "topography effect." Here, we combined such topography effect and various stimuli (chemical gradient, hypoxia, fluid motion) to create biodevices for cancer characterization and motility regulation. As one result, the interactions between the various stimuli and topography effect was deciphered at the molecular level, and thus a more precise cell regulation could be realized. These are important discoveries for cancer metastasis, and the potentials for utilizing microstructures or signal molecules associated with them in preventing metastasis was suggested.
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