Tumor blood vessel formaiton by "vascular strand invasion"
| Project/Area Number |
16H06147
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Tumor biology
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| Research Institution | Osaka University |
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Principal Investigator |
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| Research Collaborator |
HAYASHI Yumiko
MURAMATSU Fumitaka
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥27,430,000 (Direct Cost: ¥21,100,000、Indirect Cost: ¥6,330,000)
Fiscal Year 2018: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
Fiscal Year 2017: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
Fiscal Year 2016: ¥10,660,000 (Direct Cost: ¥8,200,000、Indirect Cost: ¥2,460,000)
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| Keywords | 腫瘍血管形成 / 血管移動 / 生体イメージング / 腫瘍生物学 / 血管新生 / 腫瘍 / 癌治療 / 血管束移動 |
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| Outline of Final Research Achievements |
Tumor blood vessels that supply the oxygen and nutrients to tumor tissues are necessary for tumor growth. Therefore, anti-angiogenic therapy has been considered promising therapeutic strategy for cancer treatment because inhibition of angiogenesis contributes to tumor progression. However, anti-angiogenic drug such as VEGF (Vascular endothelial growth factor) inhibitor have not bring remarkable therapeutic effects. In this study, we conducted research aimed at elucidating the Mechanisms of acquired resistance to anti-angiogenic therapy. As a result, we found a novel mechanism to acquire new tumor blood vessels by the movement of vessels. Moreover, we discovered that myeloid cell subsets are involved in the regulation of this phenomenon.
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| Academic Significance and Societal Importance of the Research Achievements |
血管を介した酸素や栄養の供給は、腫瘍を含めた全ての生体組織が成長するために必須であり、腫瘍血管の形成を抑制することで癌の治療を目指すというのは合理的な概念である。そのため、腫瘍に対する血管形成抑制剤がこれまでに際だった成果を上げていない理由を明らかにすることは、効果的な癌治療薬の開発を目指すためには重要な課題である。本研究によって発見された「血管移動」による栄養路の獲得と、それを制御する「血管制御ミエロイド」は、癌治療薬の新たな標的となると期待できる。
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Report
(3 results)
Research Products
(31 results)
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[Journal Article] CD157 Marks Tissue-Resident Endothelial Stem Cells with Homeostatic and Regenerative Properties.2018
Author(s)
Wakabayashi T, Naito H, Suehiro JI, Lin Y, Kawaji H, Iba T, Kouno T, Ishikawa-Kato S, Furuno M, Takara K, Muramatsu F, Weizhen J, Kidoya H, Ishihara K, Hayashizaki Y, Nishida K, Yoder MC, Takakura N.
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Journal Title
Cell Stem Cell.
Volume: 22
Issue: 3
Pages: 348-397
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Lysophosphatidic acid receptor 4 activation augments drug delivery in tumors by tightening endothelial cell-cell contact.2017
Author(s)
Takara K., Eino D., Ando K., Yasuda D., Naito H., Tsukada Y., Iba T., Wakabayashi T., Muramatsu F., Kidoya H., Fukuhara S., Mochizuki N., Ishii S., Kishima H., Takakura N.
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Journal Title
Cell Reports
Volume: 20
Issue: 9
Pages: 2072-2086
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Fluorescence and Bioluminescence Imaging of Angiogenesis in Flk1-Nano-lantern Transgenic Mice.2017
Author(s)
Matsushita J, Inagaki S, Nishie T, Sakasai T, Tanaka J, Watanabe C, Mizutani KI, Miwa Y, Matsumoto K, Takara K, Naito H, Kidoya H, Takakura N, Nagai T, Takahashi S, Ema M.
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Journal Title
Sci Rep.
Volume: 7
Issue: 1
Pages: 46597-46597
DOI
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Combined gene therapy with vascular endothelial growth factor plus apelin in a chronic cerebral hypoperfusion model in rats.2017
Author(s)
Hiramatsu M, Hishikawa T, Tokunaga K, Kidoya H, Nishihiro S, Haruma J, Shimizu T, Takasugi Y, Shinji Y, Sugiu K, Takakura N, Date I.
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Journal Title
J Neurosurg
Volume: 印刷中
Issue: 3
Pages: 679-686
DOI
Related Report
Peer Reviewed / Open Access
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