Study of the function and development of regulatory T cells

• Project/Area Number: 16H06295
• Research Category: Grant-in-Aid for Specially Promoted Research
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Osaka University
• Principal Investigator: Shimon Sakaguchi 大阪大学, 免疫学フロンティア研究センター, 特任教授(常勤) (30280770)
• Co-Investigator(Kenkyū-buntansha): ウィング ジェイムス 大阪大学, 免疫学フロンティア研究センター, 特任准教授(常勤) (00648694) ; 市山 健司 大阪大学, 免疫学フロンティア研究センター, 特任准教授(常勤) (60777960) ; 三上 統久 大阪大学, 免疫学フロンティア研究センター, 特任助教(常勤) (20710388)
• Project Period (FY): 2016-04-26 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥534,950,000 (Direct Cost: ¥411,500,000、Indirect Cost: ¥123,450,000); Fiscal Year 2020: ¥78,260,000 (Direct Cost: ¥60,200,000、Indirect Cost: ¥18,060,000); Fiscal Year 2019: ¥89,180,000 (Direct Cost: ¥68,600,000、Indirect Cost: ¥20,580,000); Fiscal Year 2018: ¥117,000,000 (Direct Cost: ¥90,000,000、Indirect Cost: ¥27,000,000); Fiscal Year 2017: ¥99,450,000 (Direct Cost: ¥76,500,000、Indirect Cost: ¥22,950,000); Fiscal Year 2016: ¥151,060,000 (Direct Cost: ¥116,200,000、Indirect Cost: ¥34,860,000)
• Keywords: 自己免疫寛容 / 制御性T細胞 / 自己免疫疾患 / Foxp3 / エピジェネティクス / 免疫学 / シグナル伝達 / 発現制御 / 発生・分化 / 免疫自己寛容

Outline of Final Research Achievements

This project has attempted to elucidate the molecular basis of immunosuppressive function and development of regulatory T cells (Tregs). In particular, we clarified that regulation of genomic structures at the Foxp3 locus based on Treg-specific epigenome is essential for early development of Tregs in the thymus. We also showed that functionally stable Tregs can be efficiently induced from antigen-specific conventional T cells by removal of certain signaling pathways. This enables a novel immunotherapy with functionally stable induced Tregs.
We also proved that selective depletion of tumor-infiltrating effector Tregs, which hamper effective anti-tumor immunity, can evoke and enhance anti-tumor immune responses. In addition, we found that autoimmune disease-associated SNPs are frequently accumulated in the Treg-specific DNA demethylation regions in human Tregs, suggesting the importance of genetic variations in Treg function for determining genetic susceptibility to autoimmune diseases.

Academic Significance and Societal Importance of the Research Achievements

本研究成果は、Tregの分化および免疫抑制機構の基礎的理解を進めた。その結果、Tregを標的とし、その量的・機能的減弱による、癌、病原微生物に対する新しい免疫賦活法の開発、一方、Tregの抗原特異的増殖、あるいは抗原特異的T細胞からの機能安定型Tregの分化誘導による自己免疫疾患や移植臓器拒絶反応に対する革新的治療法の開発、医療応用が期待できる。

Assessment Rating

Verification Result (Rating)

A

Research Products

• [Journal Article] CTLA-4 expression by B-1a B cells is essential for immune tolerance (2021)
  • Author(s): Yang Yang、Li Xiao、Ma Zhihai、Wang Chunlin、Yang Qunying et al
  • Journal Title: Nature Communications Volume: 12 Issue: 1 Pages: 525-525
  • DOI: 10.1038/s41467-020-20874-x
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Clinical importance of the expression of CD4+CD8+ T cells in Renal Cell Carcinoma. (2020)
  • Author(s): Nishida K, Kawashima A, Kanazawa T, Kidani Y, Yoshida T, Hirata M, Yamamoto K, Yamamoto Y, Sawada M, Kato R, Kato T, Hatano K, Ujike T, Fujita K, Uemura M, Morimoto-Okazawa A, Iwahori K, Yamasaki M, Ohkura N, Sakaguchi S, Nonomura N, Doki Y, Wada H.
  • Journal Title: Int Immunol Volume: Jan24 Issue: 5 Pages: 347-357
  • DOI: 10.1093/intimm/dxaa004
  • Peer Reviewed / Open Access
• [Journal Article] Regulatory T Cell-Specific Epigenomic Region Variants Are a Key Determinant of Susceptibility to Common Autoimmune Diseases (2020)
  • Author(s): Ohkura Naganari、Yasumizu Yoshiaki、Kitagawa Yohko、Tanaka Atsushi、Nakamura Yamami、Motooka Daisuke、Nakamura Shota、Okada Yukinori、Sakaguchi Shimon
  • Journal Title: Immunity Volume: 52 Issue: 6 Pages: 1119-1132.e4
  • DOI: 10.1016/j.immuni.2020.04.006
  • Peer Reviewed / Open Access
• [Journal Article] Epigenetic conversion of conventional T cells into regulatory T cells by CD28 signal deprivation (2020)
  • Author(s): Mikami Norihisa、Kawakami Ryoji、Chen Kelvin Y.、Sugimoto Atsushi、Ohkura Naganari、Sakaguchi Shimon
  • Journal Title: Proceedings of the National Academy of Sciences Volume: 117 Issue: 22 Pages: 12258-12268
  • DOI: 10.1073/pnas.1922600117
  • Peer Reviewed / Open Access
• [Journal Article] Transcriptional and epigenetic basis of Treg cell development and function: its genetic anomalies or variations in autoimmune diseases (2020)
  • Author(s): Ohkura Naganari、Sakaguchi Shimon
  • Journal Title: Cell Research Volume: 30 Issue: 6 Pages: 465-474
  • DOI: 10.1038/s41422-020-0324-7
  • Peer Reviewed / Open Access
• [Journal Article] Control of foreign Ag‐specific Ab responses by Treg and Tfr (2020)
  • Author(s): Wing James B.Lim Ee Lyn、Sakaguchi Shimon
  • Journal Title: Immunological Reviews Volume: 296 Issue: 1 Pages: 104-119
  • DOI: 10.1111/imr.12888
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Impaired T cell receptor signaling and development of T cell-mediated autoimmune arthritis. (2020)
  • Author(s): Takeuchi Y, Hirota K, Sakaguchi S.
  • Journal Title: Immunol Rev. Volume: 294 Issue: 1 Pages: 164-176
  • DOI: 10.1111/imr.12841
  • Peer Reviewed / Open Access
• [Journal Article] Tumour Grade Significantly Correlates With Total Dysfunction of Tumour Tissue-Infiltrating Lymphocytes in Renal Cell Carcinoma (2020)
  • Author(s): Kawashima A, Kanazawa T, Kidani Y, Yoshida T, Hirata M, Nishida K, Nojima S, Yamamoto Y, Kato T, Hatano K, Ujike T, Nagahara A, Fujita K, Morimoto-Okazawa A, Iwahori K, Uemura M, Imamura R, Ohkura N, Morii E, Sakaguchi S, Wada H, Nonomura N.
  • Journal Title: Sci Rep . Volume: 10 Issue: 1 Pages: 6220-6220
  • DOI: 10.1038/s41598-020-63060-1
  • Peer Reviewed / Open Access
• [Journal Article] Dynamics of effector and naive Regulatory T cells throughout pregnancy (2020)
  • Author(s): Shigeta Naoya、Kumasawa Keiichi、Tanaka Atsushi、Badger Wing James、Nakamura Hitomi、Sakaguchi Shimon、Kimura Tadashi
  • Journal Title: Journal of Reproductive Immunology Volume: 140 Pages: 103135-103135
  • DOI: 10.1016/j.jri.2020.103135
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Regulatory T Cells and Human Disease (2020)
  • Author(s): Sakaguchi Shimon、Mikami Norihisa、Wing James B.、Tanaka Atsushi、Ichiyama Kenji、Ohkura Naganari
  • Journal Title: Annual Review of Immunology Volume: 38 Issue: 1 Pages: 541-566
  • DOI: 10.1146/annurev-immunol-042718-041717
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Proenkephalin+regulatory T cells expanded by ultraviolet B exposure maintain skin homeostasis with a healing function (2020)
  • Author(s): Shime Hiroaki、Odanaka Mizuyu、Tsuiji Makoto、Matoba Takuma、Imai Masaki、Yasumizu Yoshiaki、Uraki Ryuta、Minohara Kiyoshi、Watanabe Maiko、Bonito Anthony John、Fukuyama Hidehiro、Ohkura Naganari、Sakaguchi Shimon、Morita Akimichi、Yamazaki Sayuri
  • Journal Title: Proceedings of the National Academy of Sciences Volume: 117 Issue: 34 Pages: 20696-20705
  • DOI: 10.1073/pnas.2000372117
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] VIRTUS: a pipeline for comprehensive virus analysis from conventional RNA-seq data (2020)
  • Author(s): Yasumizu Yoshiaki、Hara Atsushi、Sakaguchi Shimon、Ohkura Naganari
  • Journal Title: Bioinformatics Volume: btaa859 Issue: 10 Pages: 1465-1467
  • DOI: 10.1093/bioinformatics/btaa859
  • Peer Reviewed / Open Access
• [Journal Article] PTPN2 links colonic and joint inflammation in experimental autoimmune arthritis (2020)
  • Author(s): Hsieh Wan-Chen、Svensson Mattias N.D.、Zoccheddu Martina、Tremblay Michael L.、Sakaguchi Shimon、Stanford Stephanie M.、Bottini Nunzio
  • Journal Title: JCI Insight Volume: 5 Issue: 20
  • DOI: 10.1172/jci.insight.141868
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] New Treg cell-based therapies of autoimmune diseases: towards antigen-specific immune suppression (2020)
  • Author(s): Mikami Norihisa、Kawakami Ryoji、Sakaguchi Shimon
  • Journal Title: Current Opinion in Immunology Volume: 67 Pages: 36-41
  • DOI: 10.1016/j.coi.2020.07.004
  • Peer Reviewed / Open Access
• [Journal Article] Hyper-Progressive Disease: The Potential Role and Consequences of T-Regulatory Cells Foiling Anti-PD-1 Cancer Immunotherapy (2020)
  • Author(s): Tay Christopher、Qian Yamin、Sakaguchi Shimon
  • Journal Title: Cancers Volume: 13 Issue: 1 Pages: 48-48
  • DOI: 10.3390/cancers13010048
  • Peer Reviewed / Open Access
• [Journal Article] Loss of TET proteins in regulatory T cells promotes abnormal proliferation, Foxp3 destabilization, and IL-17 expression. (2019)
  • Author(s): Nakatsukasa H, Oda M, Yin J, Chikuma S, Ito M, Koga-Iizuka M, Someya K, Kitagawa Y, Ohkura N, Sakaguchi S, Koya I, Sanosaka T, Kohyama J, Tsukada YI, Yamanaka S, Takamura-Enya T, Lu Q, Yoshimura A
  • Journal Title: International immunology Volume: 31 Issue: 5 Pages: 335-347
  • DOI: 10.1093/intimm/dxz008
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Regulatory T cells expressing abundant CTLA-4 on the cell surface with a proliferative gene profile are key features of human head and neck cancer. (2019)
  • Author(s): Matoba T, Imai M, Ohkura N, Kawakita D, Ijichi K, Toyama T, Morita A, Murakami S, Sakaguchi S, Yamazaki S.
  • Journal Title: International Journal of Cancer Volume: 144(11) Issue: 11 Pages: 2811-2822
  • DOI: 10.1002/ijc.32024
  • Peer Reviewed / Open Access
• [Journal Article] Reduced expression of phosphatase PTPN2 promotes pathogenic conversion of Tregs in autoimmunity (2019)
  • Author(s): Svensson Mattias N.D, et al.
  • Journal Title: Journal of Clinical Investigation Volume: 129 Issue: 3 Pages: 1193-1210
  • DOI: 10.1172/jci123267
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Satb1 regulates the effector program of encephalitogenic tissue Th17 cells in chronic inflammation (2019)
  • Author(s): Yasuda Keiko、Kitagawa Yohko、Kawakami Ryoji、Isaka Yoshitaka、Watanabe Hitomi、Kondoh Gen、Kohwi-Shigematsu Terumi、Sakaguchi Shimon、Hirota Keiji
  • Journal Title: Nature Communications Volume: 10 Issue: 1 Pages: 549-549
  • DOI: 10.1038/s41467-019-08404-w
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Targeting Treg cells in cancer immunotherapy (2019)
  • Author(s): Tanaka Atsushi、Sakaguchi Shimon
  • Journal Title: European Journal of Immunology Volume: 49 Issue: 8 Pages: 1140-1146
  • DOI: 10.1002/eji.201847659
  • Peer Reviewed / Open Access
• [Journal Article] PD-1+ regulatory T cells amplified by PD-1 blockade promote hyperprogression of cancer (2019)
  • Author(s): Kamada Takahiro、Togashi Yosuke、Tay Christopher、Ha Danbee、Sasaki Akinori、Nakamura Yoshiaki、Sato Eiichi、Fukuoka Shota、Tada Yasuko、Tanaka Atsushi、Morikawa Hiromasa、Kawazoe Akihito、Kinoshita Takahiro、Shitara Kohei、Sakaguchi Shimon、Nishikawa Hiroyoshi
  • Journal Title: Proceedings of the National Academy of Sciences Volume: In press Issue: 20 Pages: 9999-10008
  • DOI: 10.1073/pnas.1822001116
  • Peer Reviewed / Open Access
• [Journal Article] Strain-specific manifestation of lupus-like systemic autoimmunity caused by ZAP70 mutation (2019)
  • Author(s): Takashi Matsuo, Motomu Hashimoto, Shimon Sakaguchi, Noriko Sakaguchi, Yoshinaga Ito, Masaki Hikida, Tatsuaki Tsuruyama, Kaoru Sakai, Hideki Yokoi, Mirei Shirakashi, Masao Tanaka, Hiromu Ito, Hajime Yoshifuji, Koichiro Ohmura, Takao Fujii, and Tsuneyo Mimori
  • Journal Title: The Journal of Immunology Volume: 印刷中 Issue: 11 Pages: 3161-3172
  • DOI: 10.4049/jimmunol.1801159
  • Peer Reviewed / Open Access
• [Journal Article] Enzymatic Activity of HPGD in Treg Cells Suppresses Tconv Cells to Maintain Adipose Tissue Homeostasis and Prevent Metabolic Dysfunction (2019)
  • Author(s): Schmidleithner Lisa, et al.
  • Journal Title: Immunity Volume: 50 Issue: 5 Pages: 1232-1248.e14
  • DOI: 10.1016/j.immuni.2019.03.014
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Functional Roles of the IgM Fc Receptor in the Immune System (2019)
  • Author(s): Kubagawa Hiromi、Honjo Kazuhito、Ohkura Naganari、Sakaguchi Shimon、Radbruch Andreas、Melchers Fritz、Jani Peter K.
  • Journal Title: Frontiers in Immunology Volume: 10 Pages: 945-945
  • DOI: 10.3389/fimmu.2019.00945
  • Peer Reviewed / Open Access
• [Journal Article] Regulatory roles of IL-10?producing human follicular T cells (2019)
  • Author(s): Canete Pablo F., et al.
  • Journal Title: Journal of Experimental Medicine Volume: 216 Issue: 8 Pages: 1843-1856
  • DOI: 10.1084/jem.20190493
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Theoretical modeling reveals that regulatory T cells increase T-cell interaction with antigen-presenting cells for stable immune tolerance (2019)
  • Author(s): Yamaguchi Tomoyuki、Teraguchi Shunsuke、Furusawa Chikara、Machiyama Hiroaki、Watanabe Tomonobu M、Fujita Hideaki、Sakaguchi Shimon、Yanagida Toshio
  • Journal Title: International Immunology Volume: 31 Issue: 11 Pages: 743-753
  • DOI: 10.1093/intimm/dxz043
  • Peer Reviewed / Open Access
• [Journal Article] Human FOXP3+ Regulatory T Cell Heterogeneity and Function in Autoimmunity and Cancer (2019)
  • Author(s): Wing James B.、Tanaka Atsushi、Sakaguchi Shimon
  • Journal Title: Immunity Volume: 50 Issue: 2 Pages: 302-316
  • DOI: 10.1016/j.immuni.2019.01.020
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Synovial Tissue Inflammation Mediated by Autoimmune T Cells (2019)
  • Author(s): Takeuchi Yusuke、Hirota Keiji、Sakaguchi Shimon
  • Journal Title: Frontiers in Immunology Volume: 10 Pages: 1989-1989
  • DOI: 10.3389/fimmu.2019.01989
  • NAID: 120006726173
  • Peer Reviewed / Open Access
• [Journal Article] Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition) (2019)
  • Author(s): Cossarizza A,…150 authors…,Wing, JB….16 authors… Zychlinsky A
  • Journal Title: European Journal of Immunology Volume: 49 Issue: 10 Pages: 1457-1973
  • DOI: 10.1002/eji.201970107
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Dynamic Imprinting of the Treg Cell-Specific Epigenetic Signature in Developing Thymic Regulatory T Cells (2019)
  • Author(s): Herppich S, Toker A, Pietzsch B, Kitagawa Y, Ohkura N, Miyao T, Floess S, Hori S, Sakaguchi S, Huehn J
  • Journal Title: Frontiers in Immunology Volume: 10 Pages: 2382-2382
  • DOI: 10.3389/fimmu.2019.02382
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Control of Regulatory T Cells by Co-signal Molecules (2019)
  • Author(s): Wing James Badger、Tay Christopher、Sakaguchi Shimon
  • Journal Title: Co-signal Molecules in T Cell Activation Volume: 1189 Pages: 179-210
  • DOI: 10.1007/978-981-32-9717-3_7
  • ISBN: 9789813297166, 9789813297173
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Conversion of antigen-specific effector/memory T cells into Foxp3-expressing Treg cells by inhibition of CDK8/19 (2019)
  • Author(s): Akamatsu Masahiko、Mikami Norihisa、Ohkura Naganari、Kawakami Ryoji、Kitagawa Yohko、Sugimoto Atsushi、Hirota Keiji、Nakamura Naoto、Ujihara Satoru、Kurosaki Toshio、Hamaguchi Hisao、Harada Hironori、Xia Guliang、Morita Yoshiaki、Aramori Ichiro、Narumiya Shuh、Sakaguchi Shimon
  • Journal Title: Science Immunology Volume: 4 Issue: 40
  • DOI: 10.1126/sciimmunol.aaw2707
  • Peer Reviewed / Open Access
• [Journal Article] Differential control of human Treg and effector T cells in tumor immunity by Fc-engineered anti-CTLA-4 antibody (2018)
  • Author(s): Ha Danbee、Tanaka Atsushi、Kibayashi Tatsuya、Tanemura Atsushi、Sugiyama Daisuke、Wing James Badger、Lim Ee Lyn、Teng Karen Wei Weng、Adeegbe Dennis、Newell Evan W.、Katayama Ichiro、Nishikawa Hiroyoshi、Sakaguchi Shimon
  • Journal Title: Proceedings of the National Academy of Sciences Volume: 116 Issue: 2 Pages: 609-618
  • DOI: 10.1073/pnas.1812186116
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Nod2 Deficiency Augments Th17 Responses and Exacerbates Autoimmune Arthritis. (2018)
  • Author(s): Napier RJ, Lee EJ, Vance EE, Snow PE, Samson KA, Dawson CE, Moran AE, Stenzel P, Davey MP, Sakaguchi S, Rosenzweig HL.
  • Journal Title: J. Immunol. Volume: 201 Issue: 7 Pages: 1889-1898
  • DOI: 10.4049/jimmunol.1700507
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Regulatory T-cell deficiency and autoimmune skin disease: Beyond the scurfy mouse and immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (2018)
  • Author(s): Hashimoto Takashi、Takahashi Hayato、Sakaguchi Shimon
  • Journal Title: Journal of Allergy and Clinical Immunology Volume: 142 Issue: 6 Pages: 1754-1756
  • DOI: 10.1016/j.jaci.2018.08.028
  • Peer Reviewed / Open Access
• [Journal Article] Control of Germinal Center Responses by T-Follicular Regulatory Cells (2018)
  • Author(s): Wing James B.、Tekguc Murat、Sakaguchi Shimon
  • Journal Title: Frontiers in Immunology Volume: 9 Pages: 1910-1917
  • DOI: 10.3389/fimmu.2018.01910
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Minimum Information about T Regulatory Cells: A Step toward Reproducibility and Standardization. (2018)
  • Author(s): Fuchs A, Gliwinski M, Grageda N, et al.
  • Journal Title: Front Immunol. Volume: 8 Pages: 1844-1844
  • DOI: 10.3389/fimmu.2017.01844
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Autoimmune Th17 Cells Induced Synovial Stromal and Innate Lymphoid Cell Secretion of the Cytokine GM-CSF to Initiate and Augment Autoimmune Arthritis (2018)
  • Author(s): Hirota Keiji、Hashimoto Motomu、Ito Yoshinaga、Matsuura Mayumi、Ito Hiromu、Tanaka Masao、Watanabe Hitomi、Kondoh Gen、Tanaka Atsushi、Yasuda Keiko、Kopf Manfred、Potocnik Alexandre J.、Stockinger Brigitta、Sakaguchi Noriko、Sakaguchi Shimon
  • Journal Title: Immunity Volume: 48 Issue: 6 Pages: 1220-1232
  • DOI: 10.1016/j.immuni.2018.04.009
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Innate Myeloid Cell Subset-Specific Gene Expression Patterns in the Human Colon are Altered in Crohn's Disease Patients. (2018)
  • Author(s): Sekido Y, Yasumizu Y, Nishimura J, Kayama H, Matsuno H, Ogino T, Miyoshi N, Takahashi H, Haraguchi N, Hata T, Matsuda C, Doki Y, Mori M, Takeda K, Ohkura N, Sakaguchi S, Mizushima T.
  • Journal Title: Digestion Volume: 19: Issue: 3 Pages: 1-11
  • DOI: 10.1159/000490890
  • Peer Reviewed / Open Access
• [Journal Article] Are naive T cells and class-switched memory (IgD- CD27+) B cells not essential for establishment and maintenance of pregnancy? Insights from a case of common variable immunodeficiency with pregnancy. (2018)
  • Author(s): Shigeta Naoya、Nakamura Hitomi、Kumasawa Keiichi、Imai Kohsuke、Saito Shigeru、Sakaguchi Shimon、Kimura Tadashi
  • Journal Title: Medical Hypotheses Volume: 121 Pages: 36-41
  • DOI: 10.1016/j.mehy.2018.09.014
  • Peer Reviewed / Open Access
• [Journal Article] Preoperative metabolic tumor volume of intrahepatic cholangiocarcinoma measured by 18F-FDG-PET is associated with the KRAS mutation status and prognosis. (2018)
  • Author(s): Ikeno Y, Seo S, Iwaisako K, Yoh T, Nakamoto Y, Fuji H, Taura K, Okajima H, Kaido T, Sakaguchi S, Uemoto S
  • Journal Title: J Transl Med. Volume: 16 Issue: 1 Pages: 95-95
  • DOI: 10.1186/s12967-018-1475-x
  • Peer Reviewed / Open Access
• [Journal Article] Long-term Functioning of Allogeneic Islets in Subcutaneous Tissue Pretreated with a Novel Cyclic Peptide without Immunosuppressive Medication (2018)
  • Author(s): Kuwabara Rei、Hamaguchi Masahide、Fukuda Takuya、Sakai Hiroki、Inui Makoto、Sakaguchi Shimon、Iwata Hiroo
  • Journal Title: Transplantation Volume: 102 Issue: 3 Pages: 417-425
  • DOI: 10.1097/tp.0000000000001923
  • Peer Reviewed / Open Access
• [Journal Article] Ultraviolet B?Induced Maturation of CD11b-Type Langerin?Dendritic Cells Controls the Expansion of Foxp3+Regulatory T Cells in the Skin (2017)
  • Author(s): Yamazaki Sayuri、Odanaka Mizuyu、Nishioka Akiko、Kasuya Saori、Shime Hiroaki、Hemmi Hiroaki、Imai Masaki、Riethmacher Dieter、Kaisho Tsuneyasu、Ohkura Naganari、Sakaguchi Shimon、Morita Akimichi
  • Journal Title: The Journal of Immunology Volume: 200 Issue: 1 Pages: 119-129
  • DOI: 10.4049/jimmunol.1701056
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Reciprocal regulation of the Il9 locus by counteracting activities of transcription factors IRF1 and IRF4. (2017)
  • Author(s): Carrascosa CL, Klein M, Kitagawa Y, Luckel C, Marini F, Konig A, Guralnik A, Raifer H, Hagner S, Raedler D, Bock A, Kang C, Lohoff M, Garn H, Schaub B, Berberich-Siebelt F, Sakaguchi S, Bopp T, Huber M.
  • Journal Title: Nature Communications Volume: 8 Issue: 1 Pages: 15366-15366
  • DOI: 10.1038/ncomms15366
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Guidance of regulatory T cell development by Satb1-dependent super-enhancer establishment. (2017)
  • Author(s): Kitagawa Y, Ohkura N, Kidani Y, Vandenbon A, Hirota K, Kawakami R, Yasuda K, Motooka D, Nakamura S, Kondo M, Taniuchi I, Kohwi-Shigematsu T, Sakaguchi S.
  • Journal Title: Nat Immunol. Volume: 18(2) Issue: 2 Pages: 173-183
  • DOI: 10.1038/ni.3646
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Unique properties of thymic antigen-presenting cells promote epigenetic imprinting of alloantigen-specific regulatory T cells. (2017)
  • Author(s): Garg G, Nikolouli E, Hardtke-Wolenski M, Toker A, Ohkura N, Beckstette M, Miyao T, Geffers R, Floess S, Gerdes N, Lutgens E, Osterloh A, Hori S, Sakaguchi S, Jaeckel E, Huehn J.
  • Journal Title: Oncotarget. Volume: 8(22) Issue: 22 Pages: 35542-35557
  • DOI: 10.18632/oncotarget.16221
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Novel interferon-γ enzyme-linked immunoSpot assay using activated cells for identifying hypersensitivity-inducing drug culprits. (2017)
  • Author(s): Kato K, Kawase A, Azukizawa H, Hanafusa T, Nakagawa Y, Murota H, Sakaguchi S, Asada H, Katayama I
  • Journal Title: J Dermatol Sci Volume: 86 Issue: 3 Pages: 222-229
  • DOI: 10.1016/j.jdermsci.2017.03.007
  • Peer Reviewed / Open Access
• [Journal Article] Systemic activation of NRF2 alleviates lethal autoimmune inflammation in Scurfy mice (2017)
  • Author(s): Suzuki T, Murakami S, Biswal SS, Sakaguchi S, Harigae H, Yamamoto M, Motohashi H
  • Journal Title: Mol Cell Biol Volume: 37 Issue: 15
  • DOI: 10.1128/mcb.00063-17
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Lamtor1 Is Critically Required for CD4+ T Cell Proliferation and Regulatory T Cell Suppressive Function. (2017)
  • Author(s): Hosokawa T, Kimura T, Nada S, Okuno T, Ito D, Kang S, Nojima S, Yamashita K, Nakatani T, Hayama Y, Kato Y, Kinehara Y, Nishide M, Mikami N, Koyama S, Takamatsu H, Okuzaki D, Ohkura N, Sakaguchi S, Okada M, Kumanogoh A.
  • Journal Title: J Immunol. Volume: 199 Issue: 6 Pages: 2008-2019
  • DOI: 10.4049/jimmunol.1700157
  • Peer Reviewed / Open Access
• [Journal Article] Molecular control of regulatory T cell development and function. (2017)
  • Author(s): Kitagawa Y, Sakaguchi S.
  • Journal Title: Curr Opin Immunol. Volume: 49 Pages: 64-70
  • DOI: 10.1016/j.coi.2017.10.002
  • Peer Reviewed / Open Access
• [Journal Article] Slc3a2 Mediates Branched-Chain Amino-Acid-Dependent Maintenance of Regulatory T Cells. (2017)
  • Author(s): Ikeda K, Kinoshita M, Kayama H, Nagamori S, Kongpracha P, Umemoto E, Okumura R, Kurakawa T, Murakami M, Mikami N, Shintani Y, Ueno S, Andou A, Ito M, Tsumura H, Yasutomo K, Ozono K, Takashima S, Sakaguchi S, Kanai Y, Takeda K.
  • Journal Title: Cell Reports Volume: 21 Issue: 7 Pages: 1824-1838
  • DOI: 10.1016/j.celrep.2017.10.082
  • Peer Reviewed / Open Access
• [Journal Article] UVB Exposure Prevents Atherosclerosis by Regulating Immunoinflammatory Responses. (2017)
  • Author(s): Sasaki, N., T. Yamashita, K. Kasahara, A. Fukunaga, T. Yamaguchi, T. Emoto, K. Yodoi, T. Matsumoto, K. Nakajima, T. Kita, M. Takeda, T. Mizoguchi, T. Hayashi, Y. Sasaki, M. Hatakeyama, K. Taguchi, K. Washio, S. Sakaguchi, B. Malissen, C. Nishigori, and K.I. Hirata
  • Journal Title: Arterioscler Thromb Vasc Biol Volume: 37(1) Issue: 1 Pages: 66-74
  • DOI: 10.1161/atvbaha.116.308063
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] ICOS+ Foxp3+ TILs in gastric cancer are prognostic markers and effector regulatory T cells associated with Helicobacter pylori. (2017)
  • Author(s): 長瀬 博次
  • Journal Title: Int J Cancer Volume: 140(3) Issue: 3 Pages: 686-695
  • DOI: 10.1002/ijc.30475
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Regulatory T cells in cancer immunotherapy (2017)
  • Author(s): Tanaka, A., and Sakaguchi, S.
  • Journal Title: Cell Research Volume: 27 Issue: 1 Pages: 109-118
  • DOI: 10.1038/cr.2016.151
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] T Regulatory Cells Support Plasma Cell Populations in the Bone Marrow. (2017)
  • Author(s): Glatman Zaretsky A, Konradt C, Depis F, Wing JB, Goenka R, Atria DG, Silver JS, Cho S, Wolf AI, Quinn WJ, Engiles JB, Brown DC, Beiting D, Erikson J, Allman D, Cancro MP, Sakaguchi S, Lu LF, Benoist CO, Hunter CA.
  • Journal Title: Cell Reports Volume: 18 Issue: 8 Pages: 906-916
  • DOI: 10.1016/j.celrep.2017.01.067
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Utility of CD127 combined with FOXP3 for identification of operational tolerance after liver transplantation. (2016)
  • Author(s): Nafady-Hego H, Li Y, Ohe H, Elgendy H, Zhao X, Sakaguchi S, Bishop GA, Koshiba T.
  • Journal Title: Transplant Immunology Volume: 36 Pages: 1-8
  • DOI: 10.1016/j.trim.2016.04.005
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Induction of autoimmune disease by deletion of CTLA-4 in mice in adulthood. (2016)
  • Author(s): Klocke K, Sakaguchi S, Holmdahl R, Wing K.
  • Journal Title: PNAS Volume: 113(17) Issue: 17
  • DOI: 10.1073/pnas.1603892113
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Immuno-Navigator, a batch-corrected coexpression database, reveals cell type-specific gene networks in the immune system. (2016)
  • Author(s): Vandenbon A, Dinh VH, Mikami N, Kitagawa Y, Teraguchi S, Ohkura N, Sakaguchi S.
  • Journal Title: Proc Natl Acad Sci U S A. Volume: 113(17) Issue: 17
  • DOI: 10.1073/pnas.1604351113
  • Peer Reviewed / Open Access
• [Journal Article] Dysbiosis contributes to arthritis development via activation of autoreactive T cells in the intestine. (2016)
  • Author(s): Maeda Y, Kurakawa T, Umemoto E, Motooka D, Ito Y, Gotoh K, Hirota K, Matsushita M, Furuta Y, Narazaki M, Sakaguchi N, Kayama H, Nakamura S, Iida T, Saeki Y, Kumanogoh A, Sakaguchi S, and Takeda K
  • Journal Title: Arthritis Rheum Volume: 68 Issue: 11 Pages: 2646-2661
  • DOI: 10.1002/art.39783
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Effector regulatory T cells reflect the equilibrium between antitumor immunity and autoimmunity in adult T cell leukemia. (2016)
  • Author(s): Ureshino H, Shindo T, Nishikawa H, Watanabe N, Watanabe E, Satoh N, Kitaura K, Kitamura H, Doi K, Nagase K, Kimura H, Samukawa M, Kusunoki S, Miyahara M, Shin-I T, Suzuki R, Sakaguchi S, Kimura S.
  • Journal Title: Cancer Immunol Res. Volume: 4 Pages: 644-649
  • Peer Reviewed / Open Access
• [Journal Article] Loss of the Protein Tyrosine Phosphatase PTPN22 Reduces Mannan-Induced Autoimmune Arthritis in SKG Mice. (2016)
  • Author(s): Sood S, Brownlie RJ, Garcia C, Cowan G, Salmond RJ, Sakaguchi S, Zamoyska R.
  • Journal Title: J Immunol Volume: 197 Issue: 2 Pages: 429-40
  • DOI: 10.4049/jimmunol.1502656
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Antibody to CMRF35-Like Molecule 2, CD300e A Novel Biomarker Detected in Patients with Fulminant Type 1 Diabetes. (2016)
  • Author(s): Haseda F, Imagawa A, Nishikawa H, Mitsui S, Tsutsumi C, Fujisawa R, Sano H, Murase-Mishiba Y, Terasaki J, Sakaguchi S, Hanafusa T.
  • Journal Title: PLOS ONE Volume: 11 Issue: 8 Pages: e0160576-e0160576
  • DOI: 10.1371/journal.pone.0160576
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Combination of IL-2, rapamycin, DNA methyltransferase and histone deacetylase inhibitors for the expansion of human regulatory T cells. (2016)
  • Author(s): Miyara M, Chader D, Burlion A, Goldstein J, Sterlin D, Norol F, Trebeden-Negre H, Claer L, Sakaguchi S, Marodon G, Amoura Z, Gorochov G.
  • Journal Title: Oncotarget. Volume: 8 Issue: 62 Pages: 104733-104744
  • DOI: 10.18632/oncotarget.10914
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The Proportion of Regulatory T Cells in Patients with Rheumatoid Arthritis: A Meta-Analysis. (2016)
  • Author(s): Morita T, Shima Y, Wing JB, Sakaguchi S, Ogata A, Kumanogoh A
  • Journal Title: PLOS one Volume: 11 Issue: 9 Pages: e0162306-e0162306
  • DOI: 10.1371/journal.pone.0162306
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Identification of novel and noninvasive biomarkers of acute cellular rejection after liver transplantation by protein microarray (2016)
  • Author(s): Okubo, K., Wada, H., Tanaka, A., Eguchi, E., Hamaguchi, M., Tomokuni, A., Tomimaru, Y., Asaoka, T., Hama, N., Kawamoto, K., Kobayashi, S., Marubashi, S., Nagano, H., Sakaguchi, N., Nishikawa, H., Doki, Y., Mori, M., Sakaguchi, S.
  • Journal Title: Transplant Direct Volume: 2 Issue: 12 Pages: e118-e118
  • DOI: 10.1097/txd.0000000000000630
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Two FOXP3(+)CD4(+) T cell subpopulations distinctly control the prognosis of colorectal cancers. (2016)
  • Author(s): Saito, T., Nishikawa, H., Wada, H., Nagano, Y., Sugiyama, D., Atarashi, K., Maeda, Y., Hamaguchi, M., Ohkura, N., Sato, E., Nagase, H., Nishimura, J., Yamamoto, H., Takiguchi, S., Tanoue, T., Suda, W., Morita, H., Hattori, M., Honda, K., Mori, M., Doki, Y., Sakaguchi, S.
  • Journal Title: Nat. Med Volume: 22 Issue: 6 Pages: 679-684
  • DOI: 10.1038/nm.4086
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] Treg-specific epigenetic variations and susceptibility to common autoimmune diseases (2021)
  • Author(s): Shimon Sakaguchi
  • Organizer: Immunogenomics of Disease: Accelerating to Patient Benefit
  • Int'l Joint Research / Invited
• [Presentation] Discovery of T-Regulatory Cells and Their Role in The Immune System (2021)
  • Author(s): Shimon Sakaguchi
  • Organizer: UCL Immunology Society
  • Int'l Joint Research / Invited
• [Presentation] Molecular targeting of Treg cells for controlling immune responses (2020)
  • Author(s): Shimon Sakaguchi
  • Organizer: JSA/WAO Joint Congress 2020
  • Int'l Joint Research / Invited
• [Presentation] 制御性T細胞による免疫応答制御 (2020)
  • Author(s): 坂口志文
  • Organizer: 第27回大阪小児感染免疫カンファレンス
  • Invited
• [Presentation] Basic aspects of Treg biology related to self-tolerance and autoimmune disease, and Treg-based therapeutic approach to autoimmune diseases (2020)
  • Author(s): Shimon Sakaguchi
  • Organizer: Rheuma Tolerance for Cure Annual Meeting
  • Int'l Joint Research / Invited
• [Presentation] 制御性T細胞をターゲットとした抗腫瘍免疫 (2020)
  • Author(s): 大倉永也
  • Organizer: 日本がん免疫学会
  • Invited
• [Presentation] Molecular targeting of regulatory T cells for treatment of immunological diseases. (2020)
  • Author(s): Shimon Sakaguchi
  • Organizer: FOCIS
  • Int'l Joint Research / Invited
• [Presentation] Control of immune responses by regulatory T cells (2020)
  • Author(s): Shimon Sakaguchi
  • Organizer: Robert Koch Lecture
  • Int'l Joint Research / Invited
• [Presentation] 制御性T細胞、その価値は？ (2020)
  • Author(s): 大倉永也
  • Organizer: バイオセラピー学会2020
  • Invited
• [Presentation] Multi-layer omics analysis reveals myasthenia gravis specific neuronal molecular regulation pattern (2019)
  • Author(s): Yoshiaki Yasumizu
  • Organizer: 第60回日本神経学会学術大会
• [Presentation] Phosphoinositide-3-kinase δ as a regulator of regulatory T cell immunosuppression (2019)
  • Author(s): Ee Lyn Lim
  • Organizer: The Signal Transduction in the Immune System Conference
  • Int'l Joint Research
• [Presentation] Exploring regulatory T-cell function and phenotype via mass cytometry. (2019)
  • Author(s): James Wing
  • Organizer: 8th Annual Fluidigm Mass Cytometry Summit
  • Int'l Joint Research
• [Presentation] 制御性T細胞を標的としたsingle cell解析の実際 (2019)
  • Author(s): 大倉永也
  • Organizer: シングルセルゲノミクス研究会
  • Invited
• [Presentation] 制御性T細胞を標的とした臨床応用への取り組み (2019)
  • Author(s): 大倉永也
  • Organizer: 皮膚疾患治療最前線2019
  • Invited
• [Presentation] 何が制御性T細胞の分化をドライブするのか？- 微量RNA-seq, single cell RNA-seqによるmaster regulatorの探索 (2019)
  • Author(s): 大倉永也
  • Organizer: 日本生化学会
  • Invited
• [Presentation] Cancer immunotherapy targeting regulatory T cells (2019)
  • Author(s): Atsushi Tanaka
  • Organizer: 第78回日本癌学会学術総会
• [Presentation] Regulatory T cell manipulation for enhancing anti-tumor immune activity (2019)
  • Author(s): Naganari Ohkura
  • Organizer: 18th Surugadai International Symposium & Joint Usage/Research Program of Medical Research Institute International Symposium
  • Invited
• [Presentation] CTLA-4-dependent trogocytosis promotes the interactions between Tregs and Antigen-presenting cells (2019)
  • Author(s): Tekguc Murat
  • Organizer: The 48th Annual Meeting of The Japanese Society for Immunology
• [Presentation] Single-cell transcriptomic atlas of thymic Treg development (2019)
  • Author(s): Yoshiaki Yasumizu, Naganari Ohkura, Yamami Nakamura, Atsushi Tanaka, Shimon Sakaguchi
  • Organizer: The 48th Annual Meeting of The Japanese Society for Immunology
• [Presentation] A crucial role of the conserved non-coding sequences Foxp3-CNS0 and -CNS3 in the lineage specification of thymic Foxp3+ regulatory T cells (2019)
  • Author(s): Ryoji Kawakami
  • Organizer: The 48th Annual Meeting of The Japanese Society for Immunology
• [Presentation] Exploring regulatory T-cell function and phenotype via mass cytometry (2019)
  • Author(s): James Wing
  • Organizer: The 48th Annual Meeting of The Japanese Society for Immunology
• [Presentation] High dimensional analysis of T-follicular regulatory cells (2019)
  • Author(s): James Wing
  • Organizer: The 48th Annual Meeting of The Japanese Society for Immunology
• [Presentation] EPIGENETIC LANDSCAPE OF FOXP3 ENHANCER SITES DURING THYMIC FOXP3+ TREG DEVELOPMENT OF CNS0-AND CNS3-DEFICIENT MICE (2018)
  • Author(s): R. Kawakami, Y. Kitagawa, K. Hirota, H. Watanabe, G. Kondo, K. Chen, N. Ohkura, S. Sakaguchi
  • Organizer: the 6th Annual Meeting of the International Cytokine & Interferon Society (Cytokines 2018)
  • Int'l Joint Research
• [Presentation] Distinct transcriptional regulation in tumor-infiltrating regulatory T cells. (2018)
  • Author(s): Yujiro KIdani, YohkoKitagawa, Naganari Ohkura, Shimon Sakaguchi
  • Organizer: The 47th Annual Meeting of The Japanese Society for Immunology
• [Presentation] T-follicuiar regulatory cells in human blood. (2018)
  • Author(s): James B Wing, Shimon Sakaguchi
  • Organizer: The 47th Annual Meeting of The Japanese Society for Immunology
• [Presentation] Dendritic cells expressing a unique set of genes associated with immunological tolerance are specialized to expand thymus-derived Foxp3+ regulatory T cells in the ultraviolet B-exposed skin. (2018)
  • Author(s): Sayuri Yamazaki, Mizuyu Odanaka, Akiko Nishioka,Hiroaki Shime,Hiroaki Henmi, Masaki Imai,Tsuneyasu Kaisho, Naganari Ohkura Shimon Sakaguchi, Akimichi Morita
  • Organizer: The 47th Annual Meeting of The Japanese Society for Immunology
• [Presentation] A new feature of regulatory Tcells in human head and neck cancer. (2018)
  • Author(s): Takuma Matoba, Masaki Imai, Naganari Ohkura, Daisuke Kawakita, Kei Ijichi, Tatsuya Toyama, Akimichi Morita, Shingo Murakami, Shimon Sakagichi, Sayuri Yamazaki
  • Organizer: The 47th Annual Meeting of The Japanese Society for Immunology
• [Presentation] A role of Ripk3 and Gsdmd in the development of autoimmune arthritis in SKG mice (2018)
  • Author(s): Yusuke Takeuchi, Hitomi Watanabe, Gen Kondo, Noriko Sakaguchi, Shimon Sakaguchi, Tsuneyo Mimori,Keiji Hirota:
  • Organizer: The 47th Annual Meeting of The Japanese Society for Immunology
• [Presentation] Satb1-mediated regulation of GM-CSF and PD-1 in effector Th17 cells in experimental autoimmune encephalomyelitis (2018)
  • Author(s): Keiko Yasuda, Yohko Kitagawa, Ryoji Kawakami, Hitomi Watanabe, Gen Kondo, Terumi Kohwi-Shigematsu, Shimon Sakaguchi
  • Organizer: The 47th Annual Meeting of The Japanese Society for Immunology
• [Presentation] Distinct transcriptional regulation in tumor-infiltrating regulatory T cells. (2018)
  • Author(s): Yujiro Kidani, Yohko Kitagawa, Naganari Ohkura, Shimon Sakaguchi
  • Organizer: The 8th NIF Winter School on Advanced Immunology 2019
  • Int'l Joint Research
• [Presentation] High dimensional analysis of T-follicular regulatory cells. (2018)
  • Author(s): James B Wing, Naganari Ohkura, Shimon Sakaguchi
  • Organizer: Keystone symposia: B Cell-T Cell Interactions
  • Int'l Joint Research
• [Presentation] Treg-specific control of TCR signaling molecules (2017)
  • Author(s): Atsushi Tanaka
  • Organizer: 第46回日本免疫学会総会・学術総会
• [Presentation] Epigenomic signatures of extrathymic-derived regulatory T-cells (2017)
  • Author(s): Ryoji Kawakami, Norihisa Mikami, Atsushi Sugimoto, Naganari Ohkura, Shimon Sakaguchi
  • Organizer: 第46回日本免疫学会総会・学術総会
• [Presentation] Significance of the regulatory T cell-specific epigenetics in autoimmune disease susceptibility (2017)
  • Author(s): Yoshiaki Yasumizu, Naganari Ohkura, Yohko Kitagawa, Shimon Sakaguchi
  • Organizer: 第46回日本免疫学会総会・学術総会
• [Presentation] Satb1 controls the differentiation and terminal effector function of Th17 cells (2017)
  • Author(s): Keiko Yasuda, Yohko Kitagawa, Shimon Sakaguchi
  • Organizer: 第46回日本免疫学会総会・学術総会
• [Presentation] Soluble form of CTLA-4 facilitates M2 macrophage differentiation, preferentially inhibiting Th1 but not Th2 in auto-inflammatory condition (2017)
  • Author(s): Motonao Osaki
  • Organizer: The 6th NIF Winter School on Advanced Immunology
• [Presentation] SKGマウスの関節炎に関わるILCsサブセット (2016)
  • Author(s): 廣田圭司、伊藤能永、近藤玄、田中淳、坂口教子、坂口志文
  • Organizer: Kyoto T Cell Conference
• [Presentation] Selective control of regulatory T cells through TCR signaling molecule. (2016)
  • Author(s): 田中淳、西川博嘉、野口晋佐、高橋直人、坂口教子、坂口志文
  • Organizer: Kyoto T Cell Conference
• [Presentation] Selective control of regulatory T cells through TCR signaling molecule. (2016)
  • Author(s): Atsushi Tanaka
  • Organizer: 16th International Congress of Immunology
  • Int'l Joint Research
• [Presentation] Inflammatory circuit of Th17 cells, fibroblast-like synoviocytes, and ILCs in the development of autoimmune arthritis. (2016)
  • Author(s): Keiji Hirota
  • Organizer: 16th International Congress of Immunology
  • Int'l Joint Research
• [Presentation] Epigenetic control of regulatory T cell identity and its assortiation with autoimmune diseases in human. (2016)
  • Author(s): Yohko Kitagawa, Naganari Ohkura, Yujiro Kidani, Shimon Sakaguchi
  • Organizer: 第４５回日本免疫学会総会・学術集会
• [Presentation] A distinct subset of CD25 negative T-follicular regulatory cells localizes in the germinal centers (2016)
  • Author(s): James Badger Wing, Hannah Hume, Michela Locci, Yohko Kitagawa, Christopher Tay, Kyoko Matsuda, Takeshi Inoue, Tomohiro Kurosaki, Shane Crotty, Cevayir Coban, Naganari Ohkura, Shimon Sakaguchi
  • Organizer: 第４５回日本免疫学会総会・学術集会
• [Presentation] Soluble form of CTLA-4 produced by regulatory T cells facilitates M2 macrophage differentiation in auto-inflammatory condition. (2016)
  • Author(s): Motonao Osaki, Shimon Sakaguchi
  • Organizer: 第４５回日本免疫学会総会・学術集会
• [Presentation] Specific transcriptional regulation of tumor infiltrating regulatory T cells. (2016)
  • Author(s): Yujiro Kidani, Yohko Kitagawa, Naganari Ohkura, Shimon Sakaguchi
  • Organizer: 第４５回日本免疫学会総会・学術集会
• [Presentation] Role of CTLA-4 in controlling expression of costimulatory molecules by antigen-presenting cells. (2016)
  • Author(s): Murat Tekguc, James Badger Wing, Motonao Osaki, Shimon Sakaguchi
  • Organizer: 第４５回日本免疫学会総会・学術集会
• [Presentation] Regulatory T cell precursors develop from negative selected CCR7+ Helios+ medullary thymocytes. (2016)
  • Author(s): Daniel Y. Hu, Stephen R. Daley, Christopher C. Goodnow, Naganari Ohkura, Shimon Sakaguchi
  • Organizer: 第４５回日本免疫学会総会・学術集会
• [Book] 臨床免疫・アレルギー科 Vol75 No.3 (2021)
  • Author(s): 三上統久・坂口志文
  • Total Pages: 6
  • Publisher: 科学評論社
• [Book] 臨床免疫・アレルギー科 Vol75 No.3 (2021)
  • Author(s): 安水良明・大倉永也
  • Total Pages: 3
  • Publisher: 科学評論社
• [Book] 週刊医学のあゆみVol.274 No.11 (2020)
  • Author(s): 大倉永也・坂口志文
  • Total Pages: 5
  • Publisher: 医歯薬出版
• [Book] 週刊医学のあゆみ Vol.275 No.1 (2020)
  • Author(s): 三上統久・坂口志文
  • Total Pages: 5
  • Publisher: 医歯薬出版
• [Book] 実験医学 Vol.38 No.17（増刊） (2020)
  • Author(s): 三上統久・坂口志文
  • Total Pages: 5
  • Publisher: 羊土社
• [Patent(Industrial Property Rights)] 制御性T細胞の作製法 (2018)
  • Inventor(s): 坂口 志文、三上 統久
  • Industrial Property Rights Holder: 坂口 志文、三上 統久
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2018-155507
  • Filing Date: 2018