Development of reductive dimetallation reactions

Research Project

Project/Area Number	16H06593
Research Category	Grant-in-Aid for Research Activity Start-up
Allocation Type	Single-year Grants
Research Field	Synthetic chemistry
Research Institution	Hokkaido University
Principal Investigator	DOI Ryohei 北海道大学, 薬学研究院, 助教 (40780052)
Project Period (FY)	2016-08-26 – 2018-03-31
Project Status	Completed (Fiscal Year 2017)
Budget Amount *help	¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000) Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords	還元的カップリング / ニッケル触媒 / アルキン / ニッケル / 還元剤 / カップリング反応 / 合成化学 / 有機化学
Outline of Final Research Achievements	The reductive dimetallation reaction has, unfortunately, never been realized. Instead, I have successfully developed nickel-catalyzed reductive carboxylation of ynamide with carbon dioxide. Interestingly, the regioselectivity of the carboxylation was controlled by reductant. I have already reported reductive carboxylation with zinc powder to afford dehydroamino acid at Chemical Communication. I will also prepare manuscript of reductive carboxylation using organozinc reagent. I will conduct intramolecular reaction instead of intermolecular one to achieve reductive dimetallation.