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Development of reductive dimetallation reactions

Research Project

Project/Area Number 16H06593
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Synthetic chemistry
Research InstitutionHokkaido University

Principal Investigator

DOI Ryohei  北海道大学, 薬学研究院, 助教 (40780052)

Project Period (FY) 2016-08-26 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords還元的カップリング / ニッケル触媒 / アルキン / ニッケル / 還元剤 / カップリング反応 / 合成化学 / 有機化学
Outline of Final Research Achievements

The reductive dimetallation reaction has, unfortunately, never been realized. Instead, I have successfully developed nickel-catalyzed reductive carboxylation of ynamide with carbon dioxide. Interestingly, the regioselectivity of the carboxylation was controlled by reductant. I have already reported reductive carboxylation with zinc powder to afford dehydroamino acid at Chemical Communication. I will also prepare manuscript of reductive carboxylation using organozinc reagent. I will conduct intramolecular reaction instead of intermolecular one to achieve reductive dimetallation.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • Research Products

    (2 results)

All 2017

All Journal Article (2 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 2 results)

  • [Journal Article] Nickel-Catalyzed Hydrocarboxylation of Ynamides with CO2 and H2O: An Observation of Unexpected Regioselectivity2017

    • Author(s)
      Ryohei Doi, Iman Abdullah, Takahisa Taniguchi, Nozomi Saito, Yoshihiro Sato
    • Journal Title

      Chemical Communications

      Volume: 53 Issue: 55 Pages: 7720-7723

    • DOI

      10.1039/c7cc03127k

    • NAID

      120006488397

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ligand-free Suzuki?Miyaura coupling using ruthenium(0) nanoparticles and a continuously irradiating microwave system2017

    • Author(s)
      Akiyama Toshiki、Taniguchi Takahisa、Saito Nozomi、Doi Ryohei、Honma Tetsuo、Tamenori Yusuke、Ohki Yuuta、Takahashi Naoyuki、Fujioka Hiromichi、Sato Yoshihiro、Arisawa Mitsuhiro
    • Journal Title

      Green Chemistry

      Volume: 19 Issue: 14 Pages: 3357-3369

    • DOI

      10.1039/c7gc01166k

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research

URL: 

Published: 2016-09-02   Modified: 2019-03-29  

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