Development of reductive dimetallation reactions
| Project/Area Number |
16H06593
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Synthetic chemistry
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| Research Institution | Hokkaido University |
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Principal Investigator |
DOI Ryohei 北海道大学, 薬学研究院, 助教 (40780052)
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| Project Period (FY) |
2016-08-26 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 還元的カップリング / ニッケル触媒 / アルキン / ニッケル / 還元剤 / カップリング反応 / 合成化学 / 有機化学 |
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| Outline of Final Research Achievements |
The reductive dimetallation reaction has, unfortunately, never been realized. Instead, I have successfully developed nickel-catalyzed reductive carboxylation of ynamide with carbon dioxide. Interestingly, the regioselectivity of the carboxylation was controlled by reductant. I have already reported reductive carboxylation with zinc powder to afford dehydroamino acid at Chemical Communication. I will also prepare manuscript of reductive carboxylation using organozinc reagent. I will conduct intramolecular reaction instead of intermolecular one to achieve reductive dimetallation.
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Report
(3 results)
Research Products
(2 results)
