| Project/Area Number |
16H06604
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Periodontology
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| Research Institution | Hokkaido University |
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Principal Investigator |
Nishida Erika 北海道大学, 大学病院, 医員 (50779882)
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| Project Period (FY) |
2016-08-26 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 歯周組織再生 / スキャフォールド / ナノカーボン / 酸化グラフェン / 抗菌性 / Ag / イングロース / 歯学 / 再生医学 |
|---|
| Outline of Final Research Achievements |
In this study, we aimed to demonstrate the periodontal regeneration effect by creating Ag supported nanocarbon scaffold. No cytotoxicity was observed in GO and Ag/GO scaffolds, and bacterial growth inhibitory effect was observed in Ag/GO scaffold in bacterial culture test. In the histological observation in rats, the biocompatibility of GO and Ag/GO scaffolds was better than that of collagen scaffolds. In dog extraction tooth extraction, there was no significant difference in bone regeneration at GO, Ag/GO scaffold.
From the above, it was suggested that the GO coating improves the properties of the scaffold and that the Ag/GO scaffold could exhibit antibacterial properties.
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