Evaluationt of regeneration of periodontal tissue of antibacterial scaffold using Ag/nanocarbon and
| Project/Area Number |
16H06604
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Periodontology
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| Research Institution | Hokkaido University |
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Principal Investigator |
Nishida Erika 北海道大学, 大学病院, 医員 (50779882)
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| Project Period (FY) |
2016-08-26 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 歯周組織再生 / スキャフォールド / ナノカーボン / 酸化グラフェン / 抗菌性 / Ag / イングロース / 歯学 / 再生医学 |
|---|
| Outline of Final Research Achievements |
In this study, we aimed to demonstrate the periodontal regeneration effect by creating Ag supported nanocarbon scaffold. No cytotoxicity was observed in GO and Ag/GO scaffolds, and bacterial growth inhibitory effect was observed in Ag/GO scaffold in bacterial culture test. In the histological observation in rats, the biocompatibility of GO and Ag/GO scaffolds was better than that of collagen scaffolds. In dog extraction tooth extraction, there was no significant difference in bone regeneration at GO, Ag/GO scaffold.
From the above, it was suggested that the GO coating improves the properties of the scaffold and that the Ag/GO scaffold could exhibit antibacterial properties.
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Report
(3 results)
Research Products
(19 results)
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[Journal Article] Dose effects of beta-tricalcium phosphate nanoparticles on biocompatibility and bone conductive ability of three-dimensional collagen scaffolds2017
Author(s)
S Murakami, H Miyaji, E Nishida, K Kawamoto, S Miyata, H Takita, T Akasaka, B Fugetsu, T Iwanaga, H Hongo, N Amizuka, T Sugaya, M Kawanami.
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Journal Title
Dental Materials Journal
Volume: 36
Issue: 5
Pages: 573-583
DOI
NAID
ISSN
0287-4547, 1881-1361
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Bone Induction by α-tricalcium Phosphate Microparticle Emulsion Containing Simvastatin2017
Author(s)
A Tateyema, A Kato, H Miyaji, E Nishida, Y Iwasaki, S Fujii, K Kawamoto, K Shitomi, T Furihata, K Mayumi, T Sugaya
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Journal Title
Nano Biomedicine
Volume: 9
Pages: 69-76
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Modification of composite resin surface with carbon nanotubes enhances cell proliferation2016
Author(s)
S Tanaka, H Miyaji, E Nishida, K Inoue, S Miyata, A Kato, I Kanayama, S Murakami, K Kawamoto, B Fugetsu, T Tanaka, H Takita, T Iizuka, M Kawanami
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Journal Title
Nano Biomedicine
Volume: 8
Pages: 27-34
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Periodontal tissue engineering by nano beta-tricalcium phosphate scaffold and fibroblast growth factor-2 in one-wall infrabony defects of dogs2016
Author(s)
K Ogawa, H Miyaji, A Kato, Y Kosen, T Momose, T Yoshida, E Nishida, S Miyata, S Murakami, H Takita, B Fugetsu, T Sugaya, M Kawanami
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Journal Title
J Periodont Res
Volume: 51
Issue: 6
Pages: 758-767
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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