| Project/Area Number |
16H06642
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Collagenous pathology/Allergology
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2016-08-26 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 高安動脈炎 / 自己抗体 / 内科 / 免疫学 / 循環器 / 膠原病 |
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| Outline of Final Research Achievements |
We established a method to identify autoantigens expressed on the endothelial cell surface by using retroviral vector and flow cytometry (SARF), and identified two membrane proteins as novel autoantigens in Takayasu arteritis. Each of these novel autoantibodies were detected in 36.9% and 30.4 % of patients with Takayasu arteritis. Meanwhile, they were rarely detected in other autoimmune diseases including giant cell arteritis, suggesting their high specificities in Takayasu arteritis. Each of these autoantibodies were correlated with specific clinical features and vascular legions, thus it would be possible to subclassify Takayasu arteritis by these autoantibodies. Both of autoantibodies was further revealed to possess pathogenic roles including activation of endothelial cells upon stimulation by tumor necrosis factor α (TNFα).
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