Alcohol metabolism gene polymorphism and alcohol consumption affect serum magnesium concentration in head and neck cancer cases
| Project/Area Number |
16H06774
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
ARIIZUMI Yosuke 東京医科歯科大学, 大学院医歯学総合研究科, 講師 (30444110)
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| Project Period (FY) |
2016-08-26 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 低マグネシウム血症 / 飲酒 / 遺伝子多型 / 頭頸部癌 / 腎機能障害 / シスプラチン / 化学療法 / マグネシウム / ALDH2遺伝子 / ADH1B遺伝子 / 化学放射線療法 |
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| Outline of Final Research Achievements |
A study was conducted to measure the polymorphism of alcohol metabolism - related genes and the influence of alcohol consumption on hypomagnesemia in head and neck cancer patients receiving cisplatin administration. Alcohol metabolism is affected by the ALDH2 / ADH1B gene, so magnesium is considered to be affected as well. About 20 cases of genetic tests are done at the time of the report, but we can not draw a conclusion because there are only a few cases of hypomagnesemia. We plan to add cases in the future.
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Report
(3 results)
Research Products
(12 results)
