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Alcohol metabolism gene polymorphism and alcohol consumption affect serum magnesium concentration in head and neck cancer cases

Research Project

Project/Area Number 16H06774
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Otorhinolaryngology
Research InstitutionTokyo Medical and Dental University

Principal Investigator

ARIIZUMI Yosuke  東京医科歯科大学, 大学院医歯学総合研究科, 講師 (30444110)

Project Period (FY) 2016-08-26 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords低マグネシウム血症 / 飲酒 / 遺伝子多型 / 頭頸部癌 / 腎機能障害 / シスプラチン / 化学療法 / マグネシウム / ALDH2遺伝子 / ADH1B遺伝子 / 化学放射線療法
Outline of Final Research Achievements

A study was conducted to measure the polymorphism of alcohol metabolism - related genes and the influence of alcohol consumption on hypomagnesemia in head and neck cancer patients receiving cisplatin administration. Alcohol metabolism is affected by the ALDH2 / ADH1B gene, so magnesium is considered to be affected as well. About 20 cases of genetic tests are done at the time of the report, but we can not draw a conclusion because there are only a few cases of hypomagnesemia. We plan to add cases in the future.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • Research Products

    (12 results)

All 2018 2017 2016

All Journal Article (7 results) (of which Peer Reviewed: 1 results) Presentation (5 results)

  • [Journal Article] The Present Status of Endoscopic Surgery for Sinonasal Tumors in Japan―A Nationwide Questionnaire Survey―2018

    • Author(s)
      花澤 豊行、丹生 健一、朝蔭 孝宏、小林 正佳、中川 隆之、鴻 信義、藤本 保志、児玉 悟、讃岐 徹治、田中 秀峰、有泉 陽介
    • Journal Title

      Nippon Jibiinkoka Gakkai Kaiho

      Volume: 121 Issue: 2 Pages: 119-126

    • DOI

      10.3950/jibiinkoka.121.119

    • NAID

      130006449176

    • ISSN
      0030-6622, 1883-0854
    • Related Report
      2017 Annual Research Report
  • [Journal Article] 今月の主題 咽頭・頸部食道癌の診断と治療 主題 咽頭癌の内視鏡診断─経鼻内視鏡2017

    • Author(s)
      川田 研郎、東海林 裕、岡田 隆平、清川 佑介、有泉 陽介、朝蔭 孝宏、伊藤 崇、河野 辰幸、岡田 卓也、中島 康晃、山口 和哉、川村 雄大、奥田 将史、久米 雄一郎、了徳寺 大郎、星野 明弘
    • Journal Title

      胃と腸

      Volume: 52 Issue: 13 Pages: 1665-1673

    • DOI

      10.11477/mf.1403201239

    • ISSN
      0536-2180, 1882-1219
    • Year and Date
      2017-12-25
    • Related Report
      2017 Annual Research Report
  • [Journal Article] Pediatric head and neck tumors2017

    • Author(s)
      有泉陽介, 朝蔭孝宏
    • Journal Title

      耳鼻咽喉科・頭頸部外科

      Volume: 89 Issue: 2 Pages: 140-144

    • DOI

      10.11477/mf.1411201172

    • ISSN
      0914-3491, 1882-1316
    • Year and Date
      2017-02-20
    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
  • [Journal Article] Study of Cases of Peritonsillar Abscess in the Tokyo Nishitama Area2017

    • Author(s)
      高橋 亮介、有泉 陽介、岸根 有美、冨田 誠、小田 智三
    • Journal Title

      Nippon Jibiinkoka Gakkai Kaiho

      Volume: 120 Issue: 6 Pages: 817-824

    • DOI

      10.3950/jibiinkoka.120.817

    • NAID

      130005773924

    • ISSN
      0030-6622, 1883-0854
    • Related Report
      2017 Annual Research Report
  • [Journal Article] A Case of Osteosarcoma of the Temporal Region Arising in Fibrous Dysplasia2017

    • Author(s)
      清川 佑介、有泉 陽介、野村 文敬、田崎 彰久、岡田 隆平、角田 篤信、岸本 誠司、朝蔭 孝宏
    • Journal Title

      Practica Oto-Rhino-Laryngologica

      Volume: 110 Issue: 11 Pages: 765-771

    • DOI

      10.5631/jibirin.110.765

    • NAID

      130006191469

    • ISSN
      0032-6313, 1884-4545
    • Related Report
      2017 Annual Research Report
  • [Journal Article] The effects of transoral surgery for the recurrent hypopharyngeal cancer after radiation therapy with cetuximab2017

    • Author(s)
      野村 文敬、河野 辰幸、岸本 誠司、朝蔭 孝宏、杉本 太郎、川田 研郎、角 卓郎、有泉 陽介、清川 佑介、田崎 彰久、岡田 隆平、服部 夏子
    • Journal Title

      Toukeibu Gan

      Volume: 43 Issue: 1 Pages: 28-32

    • DOI

      10.5981/jjhnc.43.28

    • NAID

      130006895190

    • ISSN
      1349-5747, 1881-8382
    • Related Report
      2017 Annual Research Report
  • [Journal Article] The safety of CRT with high-dose cisplatin for head and neck cancers in a community hospital and the renal protection effect with magnesium2016

    • Author(s)
      有泉陽介, 高橋亮介, 立石優美子, 山田雅人
    • Journal Title

      Toukeibu Gan

      Volume: 42 Issue: 3 Pages: 349-354

    • DOI

      10.5981/jjhnc.42.349

    • NAID

      130005279544

    • ISSN
      1349-5747, 1881-8382
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Presentation] 早期下咽頭癌に対する放射線療法治療成績の後方視的検討2017

    • Author(s)
      有泉 陽介, 中川 恵子, 清川 佑介, 立石 優美子, 野村 文敬, 岡田 隆平, 田崎 彰久, 吉村 亮一, 朝蔭 孝宏
    • Organizer
      頭頸部癌学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 下咽頭に発生した神経鞘腫の一例2017

    • Author(s)
      田崎彰久、清川佑介、野村文敬、岡田隆平、有泉陽介、朝蔭孝宏
    • Organizer
      日本頭頸部外科学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 舌根表在癌拾い上げに置ける上部消化管経鼻内視鏡による中咽頭反転法の有用性2017

    • Author(s)
      川田研郎、河野辰幸、杉本太郎、岡田隆平、野村文敬、清川佑介、有泉陽介、朝蔭孝宏
    • Organizer
      第41回日本頭頸部癌学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 治療強度が減弱されたにもかかわらず良好な経過をたどったHPV陽性中咽頭癌の一例2017

    • Author(s)
      朝守 智明, 野村 文敬, 有泉 陽介, 清川 佑介, 田崎 彰久, 岡田 隆平, 朝蔭 孝宏
    • Organizer
      第41回日本頭頸部癌学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ELPS+ESDを行った下咽頭〜食道を往来する下咽頭癌の1例2017

    • Author(s)
      川田研郎、中島康晃、東海林裕、星野明弘、岡田卓也、了徳寺大郎、奥田将史、久米雄一郎、Andres Mora、川村雄大、山口和哉、岡田隆平、野村文敬、清川佑介、有泉陽介、朝蔭孝宏、伊藤崇、河野辰幸
    • Organizer
      第18回頭頸部表在癌研究会
    • Related Report
      2017 Annual Research Report

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Published: 2016-09-02   Modified: 2019-03-29  

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