Developmental interaction between the thalamus and the cerebral cortex

• Project/Area Number: 16H06822
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Neurochemistry/Neuropharmacology
• Research Institution: Kanazawa University
• Principal Investigator: Ebisu Haruka 金沢大学, 医学系, 博士研究員 (40780226)
• Project Period (FY): 2016-08-26 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000); Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 視床 / 神経科学 / 大脳皮質

Outline of Final Research Achievements

We uncovered the mechanism underlying pattern formation of the mouse thalamus. Our analysis using Foxp2 (R552H) knock-in mice revealed that Foxp2 is necessary for posterior thalamic differentiation. Thalamus-specific loss-of-function studies using in utero electroporation showed that Foxp2 is important thalamus-autonomously. Injection of neuronal tracers revealed that the thalamocortical projection was also controlled by Foxp2. These results indicate that Foxp2 is an important regulator for pattern formation of the thalamus.

Research Products

• [Journal Article] Pathophysiological analyses of periventricular nodular heterotopia using gyrencephalic mammals (2017)
  • Author(s): Matsumoto N., Hoshiba Y., Morita K., Uda N., Hirota M., Minamikawa M., Ebisu H., Shinmyo Y. and Kawasaki H.
  • Journal Title: Human Molecular Genetics Volume: 26 Issue: 6 Pages: 1173-1181
  • DOI: 10.1093/hmg/ddx038
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Foxp2 regulates identities and projection patterns of thalamic nuclei during development (2017)
  • Author(s): Ebisu H., Iwai-Takekoshi L., Fujita-Jimbo E., Momoi T. and Kawasaki H.
  • Journal Title: Cerebral Cortex Volume: 印刷中 Pages: 3648-3659
  • DOI: 10.1093/cercor/bhw187
  • NAID: 120006334915
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Immunostaining of sulfatide-storing macrophages in gallbladder of a patient with metachromatic leukodystrophy (2016)
  • Author(s): Inoue N., Ikawa Y., Sato A., Yokoi A., Kuroda M., Nomura K., Sakai S., Tajima H., Ikeda H., Ebisu H., Kawasaki H., Ohta T. and Yachie A.
  • Journal Title: Pediatric Neurology Volume: 64 Pages: e3-e4
  • DOI: 10.1016/j.pediatrneurol.2016.08.006
  • Peer Reviewed
• [Journal Article] Sox11 balances dendritic morphogenesis with neuronal migration in the developing cerebral cortex (2016)
  • Author(s): Hoshiba Y., Toda T., Ebisu H., Wakimoto M., Yanagi S. and Kawasaki H.
  • Journal Title: Journal of Neuroscience Volume: 36 Issue: 21 Pages: 5775-5784
  • DOI: 10.1523/jneurosci.3250-15.2016
  • NAID: 120005830579
  • Peer Reviewed / Acknowledgement Compliant
• [Book] Brain Evolution by Design (2017)
  • Author(s): Shinmyo Y., Masuda K., Hoshiba Y., Ebisu H. and Kawasaki H.
  • Publisher: Springer Publishers