Developmental interaction between the thalamus and the cerebral cortex
Project/Area Number |
16H06822
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Research Category |
Grant-in-Aid for Research Activity Start-up
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Allocation Type | Single-year Grants |
Research Field |
Neurochemistry/Neuropharmacology
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Research Institution | Kanazawa University |
Principal Investigator |
Ebisu Haruka 金沢大学, 医学系, 博士研究員 (40780226)
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Project Period (FY) |
2016-08-26 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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Keywords | 視床 / 神経科学 / 大脳皮質 |
Outline of Final Research Achievements |
We uncovered the mechanism underlying pattern formation of the mouse thalamus. Our analysis using Foxp2 (R552H) knock-in mice revealed that Foxp2 is necessary for posterior thalamic differentiation. Thalamus-specific loss-of-function studies using in utero electroporation showed that Foxp2 is important thalamus-autonomously. Injection of neuronal tracers revealed that the thalamocortical projection was also controlled by Foxp2. These results indicate that Foxp2 is an important regulator for pattern formation of the thalamus.
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Report
(3 results)
Research Products
(5 results)
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[Journal Article] Immunostaining of sulfatide-storing macrophages in gallbladder of a patient with metachromatic leukodystrophy2016
Author(s)
Inoue N., Ikawa Y., Sato A., Yokoi A., Kuroda M., Nomura K., Sakai S., Tajima H., Ikeda H., Ebisu H., Kawasaki H., Ohta T. and Yachie A.
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Journal Title
Pediatric Neurology
Volume: 64
Pages: e3-e4
DOI
Related Report
Peer Reviewed
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