Influences of microglial lysosome dysfunction on the pathogenesis of autism spectrum disorders
| Project/Area Number |
16H06829
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Psychiatric science
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| Research Institution | Kanazawa University |
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Principal Investigator |
Zhu Hong 金沢大学, 子どものこころの発達研究センター, 博士研究員 (90778614)
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| Project Period (FY) |
2016-08-26 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 自閉スペクトラム症 / ミクログリア |
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| Outline of Final Research Achievements |
To clarify whether lysosomal dysfunction in microglia was involved in the pathogenesis of developmental disorders, we tried to established experimental models by injecting pregnant rats with poly (I:C) (polyinosinic-polycytidylic acid). By immunohistochemical staining of embryonic brains, we find out changes in lysosome-related proteins as follows: (1) Heat shock protein 70 expression was augmented in the vascular wall. (2) Lysosomal stress-related Gpnmb (glycoprotein non-metastatic melanoma B) expression was enhanced in glial cells. These data suggest that lysosomal membranes become destabilized during the pathogenesis of developmental disorders.
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Report
(3 results)
Research Products
(1 results)
