Research Project
Grant-in-Aid for Research Activity Start-up
We developed patient-derived xenograft tumor models from clinical samples of colon cancer patients. We did in vivo chemotherapy experiments using the PDX models treated with irinotecan which is one of the standard chemotherapy drugs in clinical practice of colon cancer treatment. Cancer stem cells were sorted by FACS (fluorescence activated cell sorting) and transcriptomic analysis of the sorted cells was subsequently done. Then, we have identified CDKN3 as a new mechanism of chemotherapy resistance in colon cancer cells. CDKN3 is one of the downstream targets of transcription factor E2F4 which I previously reported as a key transcription factor in the mechanism of chemotherapy resistance.
All 2017
All Presentation (2 results) (of which Int'l Joint Research: 2 results)