A novel intracellular membrane traffic-dependent regulation of cancer stem cell properties
| Project/Area Number |
16H06969
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Tumor biology
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| Research Institution | Kobe University |
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Principal Investigator |
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| Project Period (FY) |
2016-08-26 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 低分子量Gタンパク質 / ARFファミリー / がん幹細胞 / がん / 細胞内小胞輸送 / シグナル伝達 / 小胞輸送 / 癌 / ガン幹細胞 |
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| Outline of Final Research Achievements |
Cancer stem cells possess anti-apoptotic property. In order to develop effective drugs targeting cancer stem cells, it is important to elucidate the mechanism of anti-apoptotic property. We investigated the function of ARL11, a tumor-suppressor gene belonging to RAB/ARF GTPase family involved in intracellular membrane traffic. We found that the active form of ARL11 interacts with an actin-binding protein and induces apoptotic membrane blebbing. The inactive form of ARL11 localizes to a nuclear body involved in apoptosis. Our studies implicate that the interaction between ARL11 and the actin-binding protein and the intracellular localization of ARL11 are involved in anti-apoptotic property.
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Report
(3 results)
Research Products
(3 results)
