Circulating Level of Pigment Epithelium-derived Factor Is Associated with Vascular Function and Structure

• Project/Area Number: 16H07000
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Cardiovascular medicine
• Research Institution: Hiroshima University
• Principal Investigator: Kajikawa Masato 広島大学, 病院(医), 助教 (80777293)
• Project Period (FY): 2016-08-26 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000); Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 色素上皮由来因子 / 血管内皮機能 / 終末糖化産物 / 動脈硬化 / 動脈硬化危険因子

Outline of Final Research Achievements

The role of PEDF in cardiovascular disease is still controversial. The purpose of this study was to evaluate the associations between serum levels of PEDF and vascular function and structure. We measured serum levels of PEDF, assessed vascular function by measurements of FMD and nitroglycerine-induced vasodilation in the brachial artery, and measured brachial artery IMT in 150 subjects who underwent health examinations. Univariate regression analysis revealed that serum level of PEDF was significantly correlated with body mass index, high-density lipoprotein cholesterol, glucose, FMD, nitroglycerine-induced vasodilation, and brachial artery IMT. Multivariate analysis revealed that serum levels of PEDF remained an independent predictor of nitroglycerine-induced vasodilation and brachial artery IMT after adjustment of cardiovascular risk factors, while serum level of PEDF was not associated with FMD. The serum level of PEDF may be a new biochemical marker of atherosclerosis.

Research Products

• [Journal Article] Response to "circulating level of pigment epithelium-derived factor is associated with vascular function and structure: Methodological issues" (2016)
  • Author(s): Kajikawa M, Hida E, Kihara Y, Yamagishi SI, Higashi Y
  • Journal Title: Int J Cardiol Volume: - Pages: 121-121
  • DOI: 10.1016/j.ijcard.2016.10.100
  • Peer Reviewed / Open Access
• [Journal Article] Circulating Level of Pigment Epithelium-derived Factor Is Associated with Vascular Function and Structure: a Cross-sectional Study. (2016)
  • Author(s): Masato Kajikawa, Tatsuya Maruhashi, Yumiko Iwamoto, Akimichi Iwamoto, Nozomu Oda, Shinji Kishimoto, Shogo Matsui, Yoshiki Aibara, Takayuki Hidaka, Yasuki Kihara, Kazuaki Chayama, Chikara Goto, Kensuke Noma, Ayumu Nakashima, Takanori Matsui, Sho-ichi Yamagishi, Yukihito Higashi.
  • Journal Title: International Journal of Cardiology Volume: 225 Pages: 91-95
  • DOI: 10.1016/j.ijcard.2016.09.123
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] Vascular function is impaired in subjects with decreased circulating level of pigment epithelium-derived factor (2017)
  • Author(s): Masato Kajikawa, Yukihito Higashi, Tatsuya Maruhashi, Shinji Kishimoto, Shogo Matsui, Haruki Hashimoto, Farina Mohamad Yusoff, Takayuki Hidaka, Kensuke Noma, Ayumu Nakashima, Takanori Matsui, Sho-ichi Yamagishi, Yasuki Kihara
  • Organizer: 90th Scientific Sessions, American Heart Association
  • Int'l Joint Research