Hepatocellular carcinoma with vessels that encapsulated tumor clusters is associated with poor prognosis and recurrence after living donor liver transplantation.

Research Project

Project/Area Number	16H07052
Research Category	Grant-in-Aid for Research Activity Start-up
Allocation Type	Single-year Grants
Research Field	Digestive surgery
Research Institution	Kyushu University
Principal Investigator	HARADA Noboru 九州大学, 医学研究院, 准教授 (80419580)
Project Period (FY)	2016-08-26 – 2018-03-31
Project Status	Completed (Fiscal Year 2017)
Budget Amount *help	¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000) Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords	肝細胞癌 / 生体肝移植 / 類洞様血管構造 / 再発 / 脈管浸潤 / 無再発生存率 / 肝移植 / 肝血管類洞 / 類洞様血管 / 転移 / 解剖学的血管構築 / 血管新生
Outline of Final Research Achievements	As for the results, there was more tumor aggressive grade such as low differentiation, more than tumor diameter 5cm, and the progressed stage of a disease in VETC(+, 17) group than those of VETC(-, 95) group after a living donor liver transplantation for the hepatocellular carcinoma. Five-year recurrence-free survival (RFS) was significantly better in the VETC(-) than VETC(+) group after living donor liver transplantation (52.9% vs. 85.0%, p<0.001). Then, Five-year overall survival (OS) was significantly better in the VETC(-) than VETC(+) group after living donor liver transplantation (70.1% vs. 91.3%, p<0.01).Multivariate analysis showed that VETC(+) was an independent predictor of worse RFS. In conclusion, VETC(+) structure was the poorer recurrence factor in hepatocellular patients after living donor liver transplantation.