Development of therapeutic strategy with exercise-induced adipokine for nonalcoholic fatty liver disease
| Project/Area Number |
16H07070
|
|---|
| Research Category |
Grant-in-Aid for Research Activity Start-up
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Gastroenterology
|
|---|
| Research Institution | Saga University |
|---|
Principal Investigator |
|
|---|
| Research Collaborator |
TANAKA Kenichi 佐賀大学, 医学部 内科学講座 肝臓・糖尿病・内分泌内科
Goodyear Laurie J Harvard Medical School, Joslin Diabetes Center Section on Integrative Physiology and Metabolism
Xue Ruidan Fudan University, Division of Metabolism and Endocrinology
|
|---|
| Project Period (FY) |
2016-08-26 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
|---|
| Keywords | 非アルコール性脂肪性肝疾患 / 運動療法 / 肥満 / 糖尿病 / アディポカイン / NASH / 消化器病学 / トランスレーショナルリサーチ / 非アルコール性脂肪肝炎 / 医学 / 肝臓病学 |
|---|
| Outline of Final Research Achievements |
It is well known that adipose tissue secretes several cytokines as known as adipokine; however, effect of exercise training on adipokine secretion remains unclear. We obtained the fat tissue from mice and human after training and performed microArray analysis to investigate the putative adipokines. We also analyzed correlation between running distance of mice and mRNA expression of putative adipokines in adipose tissue. Consequently, Tgfb2, Gas6, Gpx3 and Lpl were identified as candidates.TGFb2 and GPX3 recombinant protein failed to change glucose and lipid metabolism of hepatocytes, whereas GAS6 increased mitochondrial function and Glut2 expression.
|
Report
(3 results)
Research Products
(6 results)
