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Development of therapeutic strategy with exercise-induced adipokine for nonalcoholic fatty liver disease

Research Project

Project/Area Number 16H07070
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Gastroenterology
Research InstitutionSaga University

Principal Investigator

Hirokazu Takahashi  佐賀大学, 医学部, 講師 (20607783)

Research Collaborator TANAKA Kenichi  佐賀大学, 医学部 内科学講座 肝臓・糖尿病・内分泌内科
Goodyear Laurie J  Harvard Medical School, Joslin Diabetes Center Section on Integrative Physiology and Metabolism
Xue Ruidan  Fudan University, Division of Metabolism and Endocrinology
Project Period (FY) 2016-08-26 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords非アルコール性脂肪性肝疾患 / 運動療法 / 肥満 / 糖尿病 / アディポカイン / NASH / 消化器病学 / トランスレーショナルリサーチ / 非アルコール性脂肪肝炎 / 医学 / 肝臓病学
Outline of Final Research Achievements

It is well known that adipose tissue secretes several cytokines as known as adipokine; however, effect of exercise training on adipokine secretion remains unclear. We obtained the fat tissue from mice and human after training and performed microArray analysis to investigate the putative adipokines. We also analyzed correlation between running distance of mice and mRNA expression of putative adipokines in adipose tissue. Consequently, Tgfb2, Gas6, Gpx3 and Lpl were identified as candidates.TGFb2 and GPX3 recombinant protein failed to change glucose and lipid metabolism of hepatocytes, whereas GAS6 increased mitochondrial function and Glut2 expression.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • Research Products

    (6 results)

All 2017 2016 Other

All Int'l Joint Research (2 results) Presentation (4 results)

  • [Int'l Joint Research] Joslin Diabetes Center/Ohio State University(アメリカ合衆国)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] Fudan University(中国)

    • Related Report
      2017 Annual Research Report
  • [Presentation] 運動惹起性アディポカインの探索2017

    • Author(s)
      高橋宏和,江口有一郎,Goodyear Laurie,安西慶三
    • Organizer
      第60回日本糖尿病学会年次学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 脂肪組織における運動効果と運動惹起性アディポカインの探索2017

    • Author(s)
      高橋宏和,江口有一郎,Goodyear Laurie,安西慶三
    • Organizer
      第37回 日本肥満学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 運動惹起性アディポカインの探索2017

    • Author(s)
      高橋宏和
    • Organizer
      第9回分子骨格筋代謝研究会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 脂肪組織における運動効果と運動惹起性アディポカインの探索2016

    • Author(s)
      高橋宏和、江口有一郎、Laurie J Goodyear、 安西慶三
    • Organizer
      第37回 日本肥満学会
    • Place of Presentation
      東京ファッションタウン
    • Year and Date
      2016-10-07
    • Related Report
      2016 Annual Research Report

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Published: 2016-09-02   Modified: 2021-12-27  

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