| Project/Area Number |
16H07089
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
General internal medicine(including psychosomatic medicine)
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| Research Institution | Kagoshima University |
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Principal Investigator |
KANDA DAISUKE 鹿児島大学, 医歯学総合研究科, 特任助教 (00781361)
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| Project Period (FY) |
2016-08-26 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 動脈硬化 / 末梢動脈疾患 / 活性化マクロファージ / マクロファージ |
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| Outline of Final Research Achievements |
Recently, the number of peripheral artery disease (PAD) is increasing dramatically. Since PAD is characterized by severe and poor prognosis, it is crucial to develop a new simple strategy to diagnose PAD by using blood sample. Recently, we demonstrated that folic acid receptor be-ta (FR be-ta) is upregulated in the activated macrophage and is related to atherosclerosis. Therefore, we hypothesized that measurement of soluble FR be-ta is useful to diagnose PAD. We measured serum soluble FR be-ta concentration and compare tis level between patients with and without PAD. Unfortunately, due to the shortage of the number of cases, we cannot obtained the significant difference.
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