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The role of a transcriptional factor GATA3 in maxillofacial development

Research Project

Project/Area Number 16H07149
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Morphological basic dentistry
Research InstitutionTohoku University (2017)
Tohoku Medical and Pharmaceutical University (2016)

Principal Investigator

Otsuki Akihito  東北大学, 東北メディカル・メガバンク機構, 助教 (30778022)

Project Period (FY) 2016-08-26 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
KeywordsGATA3 / 転写制御 / 発生・分化 / ゲノム
Outline of Final Research Achievements

GATA3 is a zinc finger transcription factor that plays a crucial role in embryonic tissue development. Here, we analyzed the expression profile of GATA3 in pharyngeal arch, and demonstrate that Gata3 hypomorphic mutant mice exhibit neonatal lethality associated with oral and renal malformation. Moreover, we found that the 662-kb Gata3 yeast artificial chromosome (YAC) recapitulated Gata3 expression in pharyngeal arch and renal tubules. A transgenic rescue mouse line generated by breeding the hypomorphic mutant with a transgenic mouse line bearing the YAC construct survived to adulthood. These result shows a crucial role for GATA3 in maxillofacial development.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • Research Products

    (9 results)

All 2018 2017 2016

All Journal Article (5 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 5 results,  Open Access: 4 results,  Acknowledgement Compliant: 2 results) Presentation (4 results)

  • [Journal Article] Derepression of the DNA Methylation Machinery of the <i>Gata1</i> Gene Triggers the Differentiation Cue for Erythropoiesis2017

    • Author(s)
      Yu L, Takai J, Otsuki A, Katsuoka F, Suzuki M, Katayama S, Nezu M, Engel JD, Moriguchi T, Yamamoto M.
    • Journal Title

      Mol Cell Biol

      Volume: 37 Issue: 8 Pages: 592-616

    • DOI

      10.1128/mcb.00592-16

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] GATA2 haploinsufficiency accelerates EVI1-driven leukemogenesis2017

    • Author(s)
      Katayama Saori、Suzuki Mikiko、Yamaoka Ayaka、Keleku-Lukwete Nadine、Katsuoka Fumiki、Otsuki Akihito、Kure Shigeo、Engel James Douglas、Yamamoto Masayuki
    • Journal Title

      Blood

      Volume: 130 Issue: 7 Pages: 908-919

    • DOI

      10.1182/blood-2016-12-756767

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Halofuginone enhances the chemo-sensitivity of cancer cells by suppressing NRF2 accumulation.2017

    • Author(s)
      Tsuchida K, Tsujita T, Hayashi M, Ojima A, Keleku-Lukwete N, Katsuoka F, Otsuki A, Kikuchi H, Oshima Y, Suzuki M, Yamamoto M.
    • Journal Title

      Free Radic Biol Med

      Volume: 103 Pages: 236-247

    • DOI

      10.1016/j.freeradbiomed.2016.12.041

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Gata3 Hypomorphic Mutant Mice Rescued with a Yeast Artificial Chromosome Transgene Suffer a Glomerular Mesangial Cell Defect.2016

    • Author(s)
      Moriguchi T, Yu L, Otsuki A, Ainoya K, Lim KC, Yamamoto M, Engel JD.
    • Journal Title

      Mol Cell Biol

      Volume: 36 Issue: 17 Pages: 2272-2281

    • DOI

      10.1128/mcb.00173-16

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Overview of redox regulation by Keap1-Nrf2 system in toxicology and cancer2016

    • Author(s)
      Suzuki M, Otsuki A, Keleku-Lukwete N, Yamamoto M
    • Journal Title

      Current Opinion in Toxicology

      Volume: 1 Pages: 29-36

    • DOI

      10.1016/j.cotox.2016.10.001

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] Maf認識配列を介した転写制御の破綻によって生じる致死的表現型の解析.2018

    • Author(s)
      大槻晃史, 勝岡史城, 山本雅之
    • Organizer
      第2回酸素生物学 & ダイイングコード合同若手会議
    • Related Report
      2017 Annual Research Report
  • [Presentation] Maf認識配列 (MARE) を介した転写制御の破綻によって生じる致死的表現型の解析2017

    • Author(s)
      大槻晃史, 勝岡史城, 山本雅之.
    • Organizer
      2017年度生命科学系学会合同年次大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 転写因子GATA3低発現マウスはメサンギウム増殖性糸球体腎炎を呈する2016

    • Author(s)
      森口尚, 于磊, 大槻晃史, 山本雅之, エンゲル ジェームスダグラス
    • Organizer
      第89回生化学会大会
    • Place of Presentation
      仙台国際センター・東北大学川内北キャンパス (仙台市)
    • Year and Date
      2016-09-25
    • Related Report
      2016 Annual Research Report
  • [Presentation] 生体の酸化ストレス防御においてNrf2-sMafへテロ二量体によって認識される特殊なシス配列の重要性.2016

    • Author(s)
      大槻晃史, 鈴木未来子, 勝岡史城, 守田匡伸, 清水律子, 山本雅之
    • Organizer
      第89回生化学会大会
    • Place of Presentation
      仙台国際センター・東北大学川内北キャンパス(仙台市)
    • Year and Date
      2016-09-25
    • Related Report
      2016 Annual Research Report

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Published: 2016-09-02   Modified: 2019-03-29  

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