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Inhibition of denture plaque deposition on complete dentures by 2-methacryloyloxyethyl phosphorylcholine polymer coating

Research Project

Project/Area Number 16H07196
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Prosthodontics/ Dental materials science and
Research InstitutionShowa University

Principal Investigator

Ikeya Kenji  昭和大学, 歯学部, 助教 (30783344)

Research Collaborator 石原 一彦  東京大学, 大学院工学系研究科マテリアル工学専攻, 教授
井上 祐貴  東京大学, 大学院工学系研究科マテリアル工学専攻, 助教
桑田 啓貴  昭和大学, 口腔微生物学教室, 教授
森崎 弘史  昭和大学, 口腔微生物学教室, 講師
山本 隆司  サンメディカル株式会社
Project Period (FY) 2016-08-26 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
KeywordsPMBPAz / MPCポリマー / デンチャープラーク / PMBPAzポリマー / 超親水性ポリマー / バイオマテリアル / denture plaque / biomaterial / 歯学 / バイオ関連機器
Outline of Final Research Achievements

The mean ±SD percentage of plaque index was 40.7% ±19.9% on the mucosal surfaces and 28.0% ±16.8% on the polished surfaces of the control denture. The mean percentage of plaque index of PMBPAz-treated dentures significantly decreased to 17.4%% ±12.0% on the mucosal surfaces (P<.001) and 15.0% ±9.9% on the polished surfaces (P<.05). These results demonstrated the effectiveness of the treatment with the PMBPAz to inhibit the bacterial plaque deposition on complete dentures.
Denture plaque-associated infection is an issue of considerable importance for denture wearers. Treatment with PMBPAz on denture surfaces is a promising, straightforward, and safe method of preventing microbial contamination on removable dentures.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • Research Products

    (5 results)

All 2018 2017 2016

All Journal Article (2 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 2 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (3 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Inhibition of denture plaque deposition on complete dentures by 2-methacryloyloxyethyl phosphorylcholine polymer coating: A clinical study2018

    • Author(s)
      Ikeya K
    • Journal Title

      The Journal of Prosthetic Dentistry

      Volume: 119(1) Issue: 1 Pages: 67-74

    • DOI

      10.1016/j.prosdent.2017.02.012

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] 2-Methacryloyloxyethyl phosphorylcholine polymer treatment of complete dentures to inhibit denture plaque deposition2016

    • Author(s)
      Ikeya K, Fukunishi M, Iwasa F, Inoue Y, Ishihara K, Baba K
    • Journal Title

      Journal of visualized experience

      Volume: 118 Issue: 118

    • DOI

      10.3791/54965

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] MPCポリマーによる”汚れない補綴装置”の開発2017

    • Author(s)
      久志本(高橋)那奈,岩佐文則,池谷賢二,福西美弥
    • Organizer
      第33回歯科医学を中心とした総合的な研究を推進する集い
    • Related Report
      2017 Annual Research Report
  • [Presentation] MPCポリマーを用いた汚れない義歯の開発2017

    • Author(s)
      福西美弥,池谷賢二,岩佐文則,馬場一美
    • Organizer
      第28回日本老年歯科医学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] The Development of Immaculate Denture with the 2-Methacryloyloxyethyl Phosphorylcholine Polymer2017

    • Author(s)
      Ikeya K, Fukunishi M, Iwasa F, Baba K
    • Organizer
      International Conference, 2017 Advances in Functional Material
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research

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Published: 2016-09-02   Modified: 2019-03-29  

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