| Project/Area Number |
16H07197
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Prosthodontics/ Dental materials science and
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| Research Institution | Showa University |
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Principal Investigator |
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| Research Collaborator |
Ishihara Kazuhiko 東京大学, 大学院工学系研究科マテリアル工学専攻
Inoue Yuuki 東京大学, 大学院工学系研究科マテリアル工学専攻
Kuwata Hirotaka 昭和大学, 口腔微生物学教室
Morisaki Hirobumi 昭和大学, 口腔微生物学教室
Yamamoto Takashi サンメディカル株式会社
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| Project Period (FY) |
2016-08-26 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | MPCポリマー / PMMA / デンチャープラーク / バイオマテリアル / バイオフィルム / 抗バイオフィルム / 義歯 / 歯科材料 |
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| Outline of Final Research Achievements |
The anti-adhesive effect against plaque accumulation, biofilm formation was inhibited more than 90% on the PMBPAz-coated surface compared to uncoated surfaces. And the PMBPAz-coating surface showed suppression of plaque accumulation even after the 1 week soaking stress. Moreover, The clinical evaluation revealed that biofilm formation on the PMBPAz-treated denture surface after 2 weeks of use was significantly inhibited compared with the original denture surface. The amount of biofilm on the PMBPAz-treated denture surfaces decreased to approximately one-fifth of that on original denture surfaces.Therefore, Remarkable and long-term inhibition of Denture plaque accumulation on PMMA surfaces can be achieved using the PMBPAz coating.
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