| Project/Area Number |
16H07326
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Environmental and hygienic pharmacy
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| Research Institution | Kyoto Pharmaceutical University |
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Principal Investigator |
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| Project Period (FY) |
2016-08-26 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 味覚 / 抗がん剤 / 副作用 / 味覚障害 / 薬学 |
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| Outline of Final Research Achievements |
Although anticancer drugs induce taste disorder, the mechanism of its onset is unknown. Therefore, there is no effective therapy for them. Aim of the present study is to elucidate the expression profiles of taste disorder and mechanism of it induced by bortezomib. Behavioral test showed that bortezomib administration induced increase of sour taste sensitivity in bortezomib-administered mice. Immunohistochemical analyses suggested that the taste alteration was result from the increase of the PKD2L1, one of the sour taste receptors. These findings would contribute to elucidate the pathophysiology of taste disorders induced by anticancer drugs.
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