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Elucidation of the pathogenesis of proteasome inhibitor-induced taste disorders

Research Project

Project/Area Number 16H07326
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Environmental and hygienic pharmacy
Research InstitutionKyoto Pharmaceutical University

Principal Investigator

Ohishi Akihiro  京都薬科大学, 薬学部, 助教 (70780089)

Project Period (FY) 2016-08-26 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords味覚 / 抗がん剤 / 副作用 / 味覚障害 / 薬学
Outline of Final Research Achievements

Although anticancer drugs induce taste disorder, the mechanism of its onset is unknown. Therefore, there is no effective therapy for them. Aim of the present study is to elucidate the expression profiles of taste disorder and mechanism of it induced by bortezomib. Behavioral test showed that bortezomib administration induced increase of sour taste sensitivity in bortezomib-administered mice. Immunohistochemical analyses suggested that the taste alteration was result from the increase of the PKD2L1, one of the sour taste receptors. These findings would contribute to elucidate the pathophysiology of taste disorders induced by anticancer drugs.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • Research Products

    (5 results)

All 2017

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (4 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Bortezomib alters sour taste sensitivity in mice2017

    • Author(s)
      AkihiroOhishi、Kentaro Nishida、Karin Miyamoto、Mizuka Imai、Ryoko Nakanishi、Kyoko Kobayashi、Akiko Hayashi、Kazuki Nagasawa
    • Journal Title

      Toxicology Reports

      Volume: 4 Pages: 172-180

    • DOI

      10.1016/j.toxrep.2017.03.003

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Bortezomibはマウスの酸味感受性を可逆的に増大させる2017

    • Author(s)
      ○岩村 萌美, 大石 晃弘, 小林 恭子, 林 亜希子, 西田 健太朗, 長澤 一樹
    • Organizer
      日本薬学会第137年会(仙台)
    • Place of Presentation
      仙台国際センター
    • Year and Date
      2017-03-24
    • Related Report
      2016 Annual Research Report
  • [Presentation] Bortezomib alters sour taste sensitivity in mice.2017

    • Author(s)
      Akihiro Ohishi, Kentaro Nishida, Kazuki Nagasawa
    • Organizer
      International Symposium on Olfaction and Taste
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Bortezomib はマウスの酸味感受性を可逆的に増大させる.2017

    • Author(s)
      岩村 萌美, 大石 晃弘, 小林 恭子, 林 亜希子, 西田 健太朗, 長澤 一樹
    • Organizer
      日本薬学会第137年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] シスプラチン投与マウスにおける苦味感受性の変化2017

    • Author(s)
      牧野 愛美, 大石 晃弘, 林 亜希子, 小林 恭子, 西田 健太朗, 長澤 一樹
    • Organizer
      日本薬学会第137年会
    • Related Report
      2017 Annual Research Report

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Published: 2016-09-02   Modified: 2019-03-29  

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