Novel method for caries prevention focusing on pathogenic bacterial biofilm formation
| Project/Area Number |
16H07386
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Fukuoka Dental College |
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Principal Investigator |
Arita Ken-ichi 福岡歯科大学, 口腔歯学部, 助教 (90780205)
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| Project Period (FY) |
2016-08-26 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | う蝕 / バイオフィルム / 病原微生物 / 低分子化合物 / Tfh / クラススイッチ / IgA / う蝕原性菌 / 動物実験 / 感染実験 / 免疫学 / 微生物 / 蛋白質 / 感染症 / 歯学 / 細菌 / 細胞 / 阻害剤 / 薬学 |
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| Outline of Final Research Achievements |
The most common infections of the oral cavity, known as dental caries, are closely related to biofilm formation of cariogenic bacteria. We tested the ability of small compounds to prevent S. mutans biofilm formation. We found the small compound inhibit biofilm formation in a dose dependent manner. In addition, we have obtained some interested result about the important antigens related to pathogenic bacteria for B cell class switch response and T cell activation.
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Report
(3 results)
Research Products
(23 results)
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[Presentation] Investigation of mechanisms underlying the T cell response in oral candidasis.2017
Author(s)
Sonoko Tasaki, Tamaki Cho, Jun-ichi Nagao, Yuka Narita, Marie Hashimoto, Shojiro Ikezaki, Kanae Yasumatsu, keita Toyoda, Ken-ichi Arita-Morioka, Hiroshi Kojima, Yoshihiko Tanaka.
Organizer
The 46th Annual Meeting of The Japanese Society for Immunology, (Sendai).
Related Report
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[Presentation] A novel alternative splicing of T-cell signaling molecule modulates TCR-mediated responses in Th2 cells.2017
Author(s)
Shojiro Ikezaki, Junichi Nagao, Marie Hashimoto, Sonoko Tasaki, Kanae Yasumatsu, K Toyoda, Yuka Narita, Kenichi Arita-Morioka, Tamaki Cho, Yoshihiko Tanaka.
Organizer
The 46th Annual Meeting of The Japanese Society for Immunology, (Sendai).
Related Report
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[Presentation] Role of a novel immune signaling molecule in Th2-type response.2016
Author(s)
Hashimoto, M., Nagao, J., Ikezaki, S., Tasaki, S., Narita, Y., Arita (Morioka), K., Yasumatsu, K., Cho, T., Yuasa, K., Tanaka, Y.
Organizer
45th Annual Meeting Japan. Soc. Immunology.
Place of Presentation
Okinawa
Year and Date
2016-12-05
Related Report
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[Presentation] Investigation of the mechanism of T cell response in oral candidasis.2016
Author(s)
Tasaki, S., Cho, T., Nagao, J., Narita, Y., Hashimoto, M., Ikezaki, S., Yasumatsu, K., Arita (Morioka), K., Kojima, H., Tanaka, Y.
Organizer
45th Annual Meeting Japan. Soc. Immunology
Place of Presentation
Okinawa
Year and Date
2016-12-05
Related Report
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