| Project/Area Number |
16H07431
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Radiation science
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| Research Institution | Southen Tohoku Research Institute for Neuroscience |
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Principal Investigator |
Tominaga Takahiro 一般財団法人脳神経疾患研究所, 南東北創薬・サイクロトロン研究所, 助手 (50778602)
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| Co-Investigator(Renkei-kenkyūsha) |
FURUMOTO Shozo 東北大学, サイクロトロン・ラジオアイソトープセンター, 教授 (00375198)
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| Project Period (FY) |
2016-08-26 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 腫瘍イメージング / ミトコンドリア / ホスホニウム / PET |
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| Outline of Final Research Achievements |
In this study, we evaluated 18F-labeled phosphonium derivatives as a tumor imaging agent. We synthesized various phosphonium derivatives and performed biological evaluation. Among them, 18F-TAP-D was selected as a candidate for a tumor imaging agent. In the cellular uptake study, good uptake of 18F-TAP-D was observed in tumor cells. However, we could not confirm the specific radioactivity accumulation to the tumor in the PET study with tumor-bearing mice.
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