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Identification of organ inductive hair follicle stem cells and its regulation mechanism

Research Project

Project/Area Number 16H07454
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field General medical chemistry
Research InstitutionInstitute of Physical and Chemical Research

Principal Investigator

Takeo Makoto  国立研究開発法人理化学研究所, 多細胞システム形成研究センター, 研究員 (50782116)

Project Period (FY) 2016-08-26 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords毛包上皮性幹細胞 / 毛包 / 培養 / 器官再生 / 毛包幹細胞 / 毛包上皮幹細胞
Outline of Final Research Achievements

The aims of this project are to elucidate the mechanism underlying the organ induction ability of hair follicle epithelial stem cells (EpiSCs) and simultaneously maintain undifferentiated status and proliferative capacity and apply to achieve hair follicle regeneration as a milestone of next generation regenerative medicine. We successfully established the culture method of bulge cells, in which EpiSCs harbors, and identified the candidate cell population for organ inductive EpiSCs and the signaling pathways involved in simultaneously maintain undifferentiated status and proliferative capacity of EpiSCs. Moreover, we confirmed that epithelial cells isolated from human scalp hair follicle can be cultured using similar culture condition. This study showed the possibility of realization of follicular organ regenerative medicine along with the academic knowledge of adult tissue stem cells that bosses the ability to induce three dimensional organs.

Academic Significance and Societal Importance of the Research Achievements

本研究により、周期的な毛包再生能を維持したまま毛包上皮性幹細胞を増幅できる培養方法の開発に成功するとともに、長期間の器官誘導能力の維持にはCD34/ Itga6/Itgb 5三重陽性細胞が重要であることが明らかとなった。
本成果は、毛包上皮性幹細胞の周期的な毛包再生や分化、運命決定のメカニズムや、上皮性幹細胞間の細胞系譜の理解などの幹細胞生物学研究に大きな貢献するとともに、本研究により確立された培養方法を応用することで、少数の毛包から大量の再生毛包を人為的に製造できることから、世界初の器官再生医療である毛包器官再生医療(毛髪再生)の実現に大きく貢献すると期待される

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • Research Products

    (6 results)

All 2017

All Presentation (4 results) (of which Int'l Joint Research: 2 results,  Invited: 4 results) Book (2 results)

  • [Presentation] Functional ectodermal organ regeneration from organ-inductive stem cells and bioengineering a 3D integumentary organ system from iPS cells2017

    • Author(s)
      Takashi Tsuji
    • Organizer
      CiRA 2017 International Symposium
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Functional ectodermal organ regeneration by bioengineered organ germs between epithelial and mesenchymal stem cells2017

    • Author(s)
      Takashi Tsuji
    • Organizer
      CDB Sympodium 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 次世代再生医療としての器官再生研究の戦略と展開2017

    • Author(s)
      辻 孝
    • Organizer
      第464日本皮膚科学会大阪地方会における第24回小林浩記念講演
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 上皮・間葉相互作用における器官再生の戦略と展開2017

    • Author(s)
      辻 孝
    • Organizer
      日本組織培養学会、日本組織培養学会第90回大会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Book] Organ Regeneration Based on Developmental Biology2017

    • Author(s)
      Takashi Tsuji
    • Total Pages
      257
    • Publisher
      NewYork on America: Humana Press
    • ISBN
      9811037663
    • Related Report
      2017 Annual Research Report
  • [Book] Organ Regeneration : 3D Stem Cell Culture & Manipulation.2017

    • Author(s)
      Takashi Tsuji
    • Total Pages
      248
    • Publisher
      NewYork on America: Humana Press
    • ISBN
      1493969471
    • Related Report
      2017 Annual Research Report

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Published: 2016-09-02   Modified: 2023-03-23  

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