Development of novel antimicrobial hybrid biomaterial aiming at application to osteomyelitis of jaw

• Project/Area Number: 16H07458
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Surgical dentistry
• Research Institution: National Defense Medical College
• Principal Investigator: MURAKAMI Kaoru 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究施設、病院並びに防衛, 病院 歯科口くう外科, 講師 (50778462)
• Project Period (FY): 2016-08-26 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000); Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 抗菌性 / 銀ナノ粒子 / 生体材料 / 骨補填材 / 顎骨骨髄炎

Outline of Final Research Achievements

Jaw osteomyelitis is a typical odontogenic infection, and it is often difficult to treat. We focused on silver nanoparticles with high antibacterial activity to control jaw osteomyelitis and developed the method to synthesize silver nanoparticles conveniently and efficiently. It was confirmed that biocompatible chitosan with nanoporous surface structure , β-TCP, atelocollagen sponge have strong antibacterial activity

Research Products

• [Journal Article] Behavior of Nitrate-Nitrogen and Nitrite-Nitrogen in Drinking Water (2018)
  • Author(s): Sato Yoko, Ishihara masayuki, Fukuda Koichi, Nakamura Shingo, Murakami Kaoru, Yokoe Hidetaka
  • Journal Title: Biocontrol Science Volume: in press
  • NAID: 130007485548
  • Peer Reviewed / Open Access
• [Journal Article] Stability of Weakly Acidic Hypochlorous Acid Solution with Microbicidal Activity (2017)
  • Author(s): Ishihara Masayuki、Murakami Kaoru、Fukuda Koichi、Nakamura Shingo、Kuwabara Masahiro、Hattori Hidemi、Fujita Masanori、Kiyosawa Tomoharu、Yokoe Hidetaka
  • Journal Title: Biocontrol Science Volume: 22 Issue: 4 Pages: 223-227
  • DOI: 10.4265/bio.22.223
  • NAID: 130006285032
  • ISSN: 1342-4815, 1884-0205
  • Peer Reviewed / Open Access
• [Journal Article] 一般歯科治療に起因した広範な顔面・頸部および縦郭気腫の2例 (2017)
  • Author(s): 村上馨，吉川秀明，峯村周，山村浩史，砂川雄貴，木村康，横江秀隆
  • Journal Title: 防衛医科大学校雑誌 Volume: 42（4） Pages: 183-188
  • Peer Reviewed
• [Journal Article] Cleansing technique using high-velocity steam?air micromist jet spray (2017)
  • Author(s): Fukuda Koichi、Ishihara Masayuki、Murakami Kaoru、Nakamura Shingo、Sato Yoko、Kuwabara Masahiro、Fujita Masanori、Kiyosawa Tomoharu、Yokoe Hidetaka
  • Journal Title: Journal of Medical Engineering & Technology Volume: 41 Issue: 7 Pages: 522-528
  • DOI: 10.1080/03091902.2017.1364309
  • Peer Reviewed / Open Access