| Project/Area Number |
16H07504
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Immunology
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| Research Institution | National Institutes of Biomedical Innovation, Health and Nutrition |
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Principal Investigator |
IIJIMA NORIFUMI 国立研究開発法人医薬基盤・健康・栄養研究所, 医薬基盤研究所 ワクチン・アジュバント研究センター, サブプロジェクトリーダー (40612552)
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| Co-Investigator(Renkei-kenkyūsha) |
Okuzaki Daisuke 大阪大学, 微生物病研究所 遺伝情報実センター ゲノム解析室, 助教 (00346131)
Tsuneki Masayuki 昭和大学, 歯学部口腔病理学部門, 助教 (40714944)
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| Project Period (FY) |
2016-08-26 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 組織局在型メモリー T 細胞 / 粘膜免疫 / 組織局在型 T 細胞 / 組織常在型 T 細胞 |
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| Outline of Final Research Achievements |
Herpes simplex virus type 2 (HSV-2) is known to cause genital herpes by recurrent activation. So far, effective vaccine against HSV-2 is not available. Towards developing vaccines to prevent HSV transmission and disease, a clear understanding of the mechanism by which immune responses are mediated within the relevant mucosal sites is necessary.
Until now, we have found that tissue-resident memory T cells (TRM) form the cluster “memory lymphocyte clusters (MLC)” beneath mucosal epithelium in mouse model of attenuated HSV immunization and HSV+ patients. In the present study, we performed RNA-sequencing analysis to identify virus transcript in vaginal tissues following HSV-2 infection. In addition, we analyzed viral antigen which is recognized by CD4+ TRM in vaginal tissue following HSV-2 infection. The data in this study clearly provide further important evidence to dissect the effector function of CD4+TRM in the near future.
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