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Exploring the neural mechanism of stuttering: individual differences in motor controls of speech, upper and lower limbs

Research Project

Project/Area Number 16K00366
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Kansei informatics
Research InstitutionGunma University

Principal Investigator

Toyomura Akira  群馬大学, 大学院保健学研究科, 准教授 (90421990)

Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Discontinued (Fiscal Year 2019)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2019: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywords吃音 / 対面会話 / 扁桃体 / 下肢運動 / マインドフルネス / 吃音の有症率と発症率 / 発話運動の模倣 / 聴覚フィードバック / 吃音(どもること) / Event-Related Potential / functional MRI / 運動時の脳計測 / 音声の生成と知覚 / マインドフルネス瞑想法 / NeuroFeedback / 聴覚誘発電位 / 運動制御 / 脳波 / fMRI / 上肢 / 下肢 / ニューロフィードバック / 発話 / 事象関連電位 / 情動 / 脳計測
Outline of Final Research Achievements

Stuttering frequency in adults who stutter and their amygdala activity were significantly correlated under the pseudo face-to-face communication. In order to measure brain activity during lower-limb movement, we developed an MR-compatible, cylindrical treadmill device and evaluated it in the real MRI scanner environment. Eight weeks of mindfulness meditation practice has significantly influenced the speech perception and production processes via auditory feedback. At the time of health care examination for 3-year-old children, the stuttering rate was 1.41% and the recovery rate was 82.8%. The recovery rate was significantly different depending on the language development at the 1.5-year health checkup. There was hemispheric laterality in the speech motor area during speech imitation. It was different depending on the familiarity level of the language.

Academic Significance and Societal Importance of the Research Achievements

吃音は発話流暢性の障害であり,言語に関係なく世界に共通して吃音話者がいると考えられるが,吃音そのものの理解やメカニズムの解明は遅れている。社会における吃音の認知度も依然として低い。吃音に関する生理や行動の記述と,データに基づいたメカニズムの考察は,将来的には吃音への対応方法の改善につながると考える。本研究は吃音話者の神経活動や行動特性等を多角的に調査して,吃音のメカニズムの一部を明らかにすることを目標とした。

Report

(4 results)
  • 2019 Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (23 results)

All 2019 2018 2017 2016 Other

All Int'l Joint Research (4 results) Journal Article (6 results) (of which Peer Reviewed: 6 results,  Open Access: 2 results,  Acknowledgement Compliant: 1 results) Presentation (13 results) (of which Int'l Joint Research: 2 results,  Invited: 1 results)

  • [Int'l Joint Research] Macquarie University(オーストラリア)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] Max Planck Institute(ドイツ)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] Macquarie University(オーストラリア)

    • Related Report
      2017 Research-status Report
  • [Int'l Joint Research] University of Hull(英国)

    • Related Report
      2017 Research-status Report
  • [Journal Article] Altered auditory feedback perception following an 8-week mindfulness meditation practice2019

    • Author(s)
      Miyashiro D, Toyomura A, Haitani T, Kumano H.
    • Journal Title

      Int J Psychophysiol

      Volume: 138 Pages: 38-46

    • DOI

      10.1016/j.ijpsycho.2019.01.010

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hemispheric laterality of the motor cortex involved in imitation of lip movement2018

    • Author(s)
      Toyomura A., Fujii T., Kuriki S.
    • Journal Title

      Acoustical Science and Technology

      Volume: 39 Issue: 6 Pages: 432-435

    • DOI

      10.1250/ast.39.432

    • ISSN
      0369-4232, 1346-3969, 1347-5177
    • Year and Date
      2018-11-01
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Turning a cylindrical treadmill with feet: An MR-compatible device for assessment of the neural correlates of lower-limb movement2018

    • Author(s)
      Akira Toyomura, Koichi Yokosawa, Atsushi Shimojo, Tetsunoshin Fujii, Shinya Kuriki
    • Journal Title

      Journal of Neuroscience Methods

      Volume: 307 Pages: 14-22

    • DOI

      10.1016/j.jneumeth.2018.06.006

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Speech Disfluency-dependent Amygdala Activity in Adults Who Stutter: Neuroimaging of Interpersonal Communication in MRI Scanner Environment2018

    • Author(s)
      Toyomura A, Fujii T, Yokosawa K, Kuriki S
    • Journal Title

      Neuroscience

      Volume: 374 Pages: 144-154

    • DOI

      10.1016/j.neuroscience.2018.01.037

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Children who stutter at 3 years of age: A community-based study2018

    • Author(s)
      Shimada M, Toyomura A, Fujii T, Minami T
    • Journal Title

      Journal of Fluency Disorders

      Volume: 56 Pages: 45-54

    • DOI

      10.1016/j.jfludis.2018.02.002

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Fluctuation of Lower Limb Movement in the MRI Bore: Different Contributions of the Cortical and Subcortical Locomotor Regions2017

    • Author(s)
      Toyomura A, Yokosawa K, Kuriki S
    • Journal Title

      Advanced Biomedical Engineering

      Volume: 6 Issue: 0 Pages: 15-20

    • DOI

      10.14326/abe.6.15

    • NAID

      130005402002

    • ISSN
      2187-5219
    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] Timing disorder of adults who stutter: Evidence from bimanual coordination tasks2018

    • Author(s)
      Toyomura A., Fujii T., Sowman PF.
    • Organizer
      IFA World Congress 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Tele-therapy of a child who stutters: a case study using sound recording and e-mail2018

    • Author(s)
      Shimada M., Fujii T., Toyomura A.
    • Organizer
      IFA World Congress 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 下肢運動に関連する脳活動を計測するための手法の検討2018

    • Author(s)
      豊村暁、横澤宏一、下條暁司、藤井哲之進、栗城眞也
    • Organizer
      第12回Motor Control研究会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 呼吸に同期した純音の提示による数息観時のマインドワンダリング抑制効果の検討2018

    • Author(s)
      星野孝文、豊村暁、寺内萌絵、髙橋徹、廣神佑香、成島響子、灰谷知純、熊野宏昭、三井真一
    • Organizer
      第65回北関東医学会総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 脳波を用いたマインドフルネス瞑想中のニューロフィードバックに関する研究2018

    • Author(s)
      寺内萌絵、豊村暁、星野孝文、髙橋徹、成島響子、廣神佑香、灰谷知純、三井真一、熊野宏昭
    • Organizer
      第65回北関東医学会総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] バイオフィードバックを用いた数息観時のマインドワンダリング抑制効果の検討2018

    • Author(s)
      星野孝文、豊村暁、寺内萌絵、髙橋徹、廣神佑香、成島響子、灰谷知純、熊野宏昭、三井真一
    • Organizer
      日本生体医工学会関東支部 若手研究者発表会2018
    • Related Report
      2018 Annual Research Report
  • [Presentation] 話者の声の大きさと好みの大きさの関係についての考察2018

    • Author(s)
      豊村 暁, 藤井哲之進, Kazuyo Nakabayashi, David R Smith, 外山淳, 川端康弘
    • Organizer
      日本音響学会2018年春季研究発表会
    • Related Report
      2017 Research-status Report
  • [Presentation] 口唇運動の模倣に関与する神経機構の検討2017

    • Author(s)
      豊村暁,藤井哲之進,栗城眞也
    • Organizer
      日本音響学会2017年春季研究発表会
    • Place of Presentation
      川崎市
    • Year and Date
      2017-03-15
    • Related Report
      2016 Research-status Report
  • [Presentation] 対面会話中の吃頻度に相関する扁桃体の活動2017

    • Author(s)
      豊村暁, 藤井哲之進, 横澤宏一, 栗城眞也
    • Organizer
      日本吃音・流暢性障害学会第5回大会
    • Related Report
      2017 Research-status Report
  • [Presentation] マインドフルネス瞑想訓練による聴覚フィードバック知覚の変化2017

    • Author(s)
      宮代大輝, 豊村暁, 灰谷知純, 熊野宏昭
    • Organizer
      日本吃音・流暢性障害学会第5回大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 吃音のメカニズムに関する研究の紹介2016

    • Author(s)
      豊村暁
    • Organizer
      北見吃音サロン「なんだろう?吃音 ~早期発見と早期支援の必要性,社会的支援の意義を考える」
    • Place of Presentation
      北見市
    • Year and Date
      2016-10-15
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] Fluctuation of lower limb movement in the MRI Bore: Different contributions of the cortical and subcortical locomotor region.2016

    • Author(s)
      Toyomura A, Yokosawa K, Kuriki S
    • Organizer
      生体医工学シンポジウム2016
    • Place of Presentation
      所沢市
    • Year and Date
      2016-09-17
    • Related Report
      2016 Research-status Report
  • [Presentation] 遅延聴覚フィードバック音声に対する聴覚誘発電位の測定方法についての検討2016

    • Author(s)
      豊村暁, 宮代大輝, 栗城眞也
    • Organizer
      第4回吃音・流暢性障害学会
    • Place of Presentation
      所沢市
    • Year and Date
      2016-09-02
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2022-02-21  

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