Research on the mechanism(s) underlying amelioration of pathological model of cerebral stroke by fully hydrogenated oil
| Project/Area Number |
16K00817
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Eating habits
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| Research Institution | Gifu Pharmaceutical University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 完全水添油脂 / SHRSP / ステアリン酸 / 植物ステロール / 脂質栄養 / DHA / 飽和脂肪酸 / 脳卒中 / 食素材 |
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| Outline of Final Research Achievements |
Fully hydrogenated canola oil (FHCO) ameliorate the pathology of spontaneously hypertensive rats stroke-prone (SHRSP). Then, elevating docosahexaenoic acid (DHA) level and decreasing phytosterol level in rat tissue were observed, suggesting that these alteration of tissue lipid levels might be related with the amelioration. FHCO diet increased the level of feces and fat level in feces, leading to promote the selective elimination and accumulation in rat tissue. However, FHCO diet without DHA was also seen the recover from some illness, so we further checked the investigation about the mechanisms of FHCO
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| Academic Significance and Societal Importance of the Research Achievements |
本研究は、完全水添油脂がSHRSPという特殊な病態モデルラットの病態を、特殊な排泄促進により改善することを証明している。ヒトを含んだ他の動物種にも直接適応することが難しいのは、他の検討から明らかではあるが、90％以上も飽和脂肪酸を含むFHCO単独給餌でいくつかの病態改善作用が認められることは、FHCO、もしくは、飽和脂肪酸の適量摂取により引き起こされる未知の生理作用が存在する可能性があり、栄養学的に新たな展開が期待される。
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Report
(4 results)
Research Products
(5 results)
