Evaluation of nutritional status by analysis of stable isotope ratio and trance elements in scalp hair and application to medical cares
| Project/Area Number |
16K00863
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Eating habits
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| Research Institution | Health Sciences University of Hokkaido |
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Principal Investigator |
ENDO Tetsuya 北海道医療大学, 薬学部, 准教授 (10133216)
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| Co-Investigator(Kenkyū-buntansha) |
木村 治 北海道医療大学, 薬学部, 講師 (10418882)
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| Research Collaborator |
KIMURA Osamu
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2018: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 頭髪 / 炭素安定同位体 / 窒素安定同位体 / 微量元素 / 経腸栄養 / 中心静脈栄養 / 糖尿病 / クローン病 / 経腸栄養剤 / 中心静脈栄養剤 / 窒素安定同位体比 / 炭素安定同位体比 / エネルギー / 安定同位体 / 静脈経腸栄養 / アミノ酸 |
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| Outline of Final Research Achievements |
The aim of the study by measuring carbon and nitrogen stable isotopes and trace elements in the scalp hair is the evaluation of patient's nutritional status and application to diagnosis and treatment of diseases related to food. The main targets are patients who have been under nutritional management for a long time with enteral nutrition or total parenteral nutrition, diabetes patients, and Crohn's disease patients.
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| Academic Significance and Societal Importance of the Research Achievements |
頭髪は血液と比べて採取が容易で、感染の心配もない。また保存や運搬も容易である。頭髪は１月に約１cm伸長することから、長期間の情報を得ることが可能である。慢性的な疾病の診断や栄養状態の推定に適した生体試料である。本研究では、頭髪中の炭素および窒素安定同位体と各種微量元素を測定することで、食に関する疾病を診断を試みた。
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Report
(4 results)
Research Products
(17 results)
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[Journal Article] Nutritional assessment using stable isotope ratios of carbon and nitrogen in the scalp hair of geriatric patients who received enteral and parenteral nutrition formulas2017
Author(s)
Hayasaka, M., Ogasawara, H., Hotta, Y., Tsukagoshi, K., Kimura, O., Kura, T., Tarumi, T., Muramatsu, H., and Endo, T.
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Journal Title
Clin. Nutr.
Volume: 36
Issue: 6
Pages: 1661-1668
DOI
Related Report
Peer Reviewed
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[Journal Article] Correlation between mercury concentration, and stable isotope ratios of carbon and nitrogen of amino acids in scalp hair from whale meat eaters and heavy fisheaters.2017
Author(s)
Endo, T., Hayasaka, M., Ogasawara, H., Hotta, Y., Kimura, O., Petzke, K,J.
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Journal Title
Rapid Commun. Mass Spectrom
Volume: 31
Issue: 9
Pages: 745-752
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Uptake of perfluorooctanoic acid by Caco-2 cells: Involvement of organic anion transporting polypeptides2017
Author(s)
Kimura, O., Fuji, Y., Haraguchi, K., Kato, Y., Ohta, C., Koga, K., Endo, T
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Journal Title
Toxicol. Let.
Volume: 印刷中
Related Report
Peer Reviewed / Acknowledgement Compliant
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