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Evaluation of nutritional status by analysis of stable isotope ratio and trance elements in scalp hair and application to medical cares

Research Project

Project/Area Number 16K00863
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Eating habits
Research InstitutionHealth Sciences University of Hokkaido

Principal Investigator

ENDO Tetsuya  北海道医療大学, 薬学部, 准教授 (10133216)

Co-Investigator(Kenkyū-buntansha) 木村 治  北海道医療大学, 薬学部, 講師 (10418882)
Research Collaborator KIMURA Osamu  
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2018: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords頭髪 / 炭素安定同位体 / 窒素安定同位体 / 微量元素 / 経腸栄養 / 中心静脈栄養 / 糖尿病 / クローン病 / 経腸栄養剤 / 中心静脈栄養剤 / 窒素安定同位体比 / 炭素安定同位体比 / エネルギー / 安定同位体 / 静脈経腸栄養 / アミノ酸
Outline of Final Research Achievements

The aim of the study by measuring carbon and nitrogen stable isotopes and trace elements in the scalp hair is the evaluation of patient's nutritional status and application to diagnosis and treatment of diseases related to food. The main targets are patients who have been under nutritional management for a long time with enteral nutrition or total parenteral nutrition, diabetes patients, and Crohn's disease patients.

Academic Significance and Societal Importance of the Research Achievements

頭髪は血液と比べて採取が容易で、感染の心配もない。また保存や運搬も容易である。頭髪は1月に約1cm伸長することから、長期間の情報を得ることが可能である。慢性的な疾病の診断や栄養状態の推定に適した生体試料である。本研究では、頭髪中の炭素および窒素安定同位体と各種微量元素を測定することで、食に関する疾病を診断を試みた。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (17 results)

All 2019 2018 2017 2016 Other

All Int'l Joint Research (2 results) Journal Article (8 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 8 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (7 results)

  • [Int'l Joint Research] German Institute of Human Nutrition/Potsdom-Rehbruecke(ドイツ)

    • Related Report
      2016 Research-status Report
  • [Int'l Joint Research]

    • Related Report
      2016 Research-status Report
  • [Journal Article] Assessment of diabetics by the quantification of essential elements and stable isotope ratios of carbon and nitrogen in scalp hair2019

    • Author(s)
      Hotta Yohei、Fujino Ryoji、Kimura Osamu、Fujii Yukiko、Haraguchi Koichi、Endo Tetsuya
    • Journal Title

      Obesity Medicine

      Volume: 印刷中 Pages: 100106-100106

    • DOI

      10.1016/j.obmed.2019.100106

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Essential and non-essential elements in scalp hair of diabetes: Correlation with glycated hemoglobin (HbA1c)2018

    • Author(s)
      Hotta, Y., Fujino, R., Kimura, O., Endo, T.
    • Journal Title

      Bio. Pharmacol. Bull.

      Volume: 41 Pages: 1034-1039

    • NAID

      130007387184

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Stable isotope ratios of carbon, nitrogen and selenium concentration in the scalp hair of Crohn's disease patients who ingested the elemental diet Elental ?2018

    • Author(s)
      Ogasawara Hideki、Hayasaka Moriaki、Maemoto Atsuo、Furukawa Shigeru、Ito Takahiro、Kimura Osamu、Endo Tetsuya
    • Journal Title

      Rapid Communications in Mass Spectrometry

      Volume: 33 Issue: 1 Pages: 41-48

    • DOI

      10.1002/rcm.8296

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nutritional assessment using stable isotope ratios of carbon and nitrogen in the scalp hair of geriatric patients who received enteral and parenteral nutrition formulas2017

    • Author(s)
      Hayasaka, M., Ogasawara, H., Hotta, Y., Tsukagoshi, K., Kimura, O., Kura, T., Tarumi, T., Muramatsu, H., and Endo, T.
    • Journal Title

      Clin. Nutr.

      Volume: 36 Issue: 6 Pages: 1661-1668

    • DOI

      10.1016/j.clnu.2016.10.017

    • Related Report
      2017 Research-status Report 2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Correlation between mercury concentration, and stable isotope ratios of carbon and nitrogen of amino acids in scalp hair from whale meat eaters and heavy fisheaters.2017

    • Author(s)
      Endo, T., Hayasaka, M., Ogasawara, H., Hotta, Y., Kimura, O., Petzke, K,J.
    • Journal Title

      Rapid Commun. Mass Spectrom

      Volume: 31 Issue: 9 Pages: 745-752

    • DOI

      10.1002/rcm.7841

    • Related Report
      2017 Research-status Report 2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Uptake of perfluorooctanoic acid by Caco-2 cells: Involvement of organic anion transporting polypeptides2017

    • Author(s)
      Kimura, O., Fuji, Y., Haraguchi, K., Kato, Y., Ohta, C., Koga, K., Endo, T
    • Journal Title

      Toxicol. Let.

      Volume: 印刷中

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] 経腸栄養剤投与患者の頭髪中窒素および炭素安定同位体比を用いた栄養状態の評価2016

    • Author(s)
      早坂敬明、木村治、倉敏郎、遠藤哲也
    • Journal Title

      医療薬学

      Volume: 42 Pages: 151-159

    • NAID

      130005440134

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Metal concentraions in the liver and stable isotope ratios of carbon and nitrogen in the muscle of silvertip sharks (Carchhinus albimarginatus) culled off Ishigaki Island, Japan: Changes with growth2016

    • Author(s)
      Tetsuya Endo, Osamu Kimura, Chiho Ohta, Nobuyuki Koga, Yoshihisa Kato, Yukiko Fujii, Koichi Haraguchi
    • Journal Title

      PlOS ONE

      Volume: 11

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 中心静脈栄養輸液製剤により長期間栄養管理を受けた高齢者の頭髪中炭素・窒素の安定同位体比の変化2019

    • Author(s)
      木村治、堀田洋平、垂水隆志、五十君篤哉、早坂敬明、浜上尚也、遠藤哲也
    • Organizer
      第3回日本老年薬学会学術大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 陽イオン含有内服薬とハイネイーゲルおよびマーメッドとの配合におけるLST値の変化2017

    • Author(s)
      早坂敬明、金崎修治、松田純和、齋藤靖弘、内山絵里、菅沼宏之、岩岡敦子、 梅田あかね、今井隆樹、木村治、遠藤哲也、武田清孝
    • Organizer
      日本静脈経腸栄養学会
    • Place of Presentation
      岡山
    • Year and Date
      2017-02-23
    • Related Report
      2016 Research-status Report
  • [Presentation] 長期静脈栄養管理によるセレン欠乏の2例報告2017

    • Author(s)
      遠藤 哲也
    • Organizer
      第22回PEG・在宅医療学会 札幌
    • Related Report
      2017 Research-status Report
  • [Presentation] 長期静脈栄養管理によるセレン欠乏の1例報告 患者頭髪中の微量元素と炭素および窒素安定同位体の分析ついて2017

    • Author(s)
      藤野 陵二、村松 博士、木村 治、佐藤 英二、遠藤 哲也
    • Organizer
      第27回日本医療薬学年会
    • Related Report
      2017 Research-status Report
  • [Presentation] 成分栄養剤服用による頭髪中窒素・炭素の安定同位体比とセレンの変化について2017

    • Author(s)
      小笠原英樹、井上純孝、木村 治、遠藤 哲也
    • Organizer
      第27回日本医療薬学年会
    • Related Report
      2017 Research-status Report
  • [Presentation] 糖尿病患者頭髪中の微量元素とHbA1cとの関係について2016

    • Author(s)
      藤野 陵二、堀田 洋平、木村 治、佐藤 英二、遠藤 哲也
    • Organizer
      日本医療薬学会第26回
    • Place of Presentation
      京都
    • Year and Date
      2016-09-17
    • Related Report
      2016 Research-status Report
  • [Presentation] 糖尿病患者の頭髪成分分析について-安定同位体と微量元素分析による健常人との比較-(第二報)2016

    • Author(s)
      堀田 洋平、藤野 陵二、早坂 敬明、小笠原 英樹、塚越 建介、木村 治、垂水 隆志、遠藤 哲也
    • Organizer
      第59回糖尿病学会
    • Place of Presentation
      京都
    • Year and Date
      2016-05-19
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2020-03-30  

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