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Satisfaction and usefulness of low potassium vegetables for patients with chronic kidney disease

Research Project

Project/Area Number 16K00871
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Eating habits
Research InstitutionTeikyo University

Principal Investigator

Uchida Shunya  帝京大学, 医学部, 教授 (50151882)

Co-Investigator(Kenkyū-buntansha) 柴田 茂  帝京大学, 医学部, 教授 (60508068)
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2017: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords慢性腎臓病 / 血液透析 / 高カリウム血症 / 低カリウム野菜 / 生活の質 / 機能性食品
Outline of Final Research Achievements

Hemodialysis patients exceed 330,000 as the terminal stage of chronic kidney disease (CKD). Hyperkalemia, a complication of CKD, has made CKD patients restricted to take fresh vegetables. We examined the satisfaction and usefulness of incorporating low potassium vegetables made possible by hydroponic culture.
First, the questionnaire revealed that both patients and healthcare practioners are nervous about hyperkalemia and feel stressful about its management. Next, we conducted the clinical study on satisfaction and usefulness of low potassium vegetables in maintenance hemodialysis patients. The feedback on eating low potassium lettuce for three months was favorable, and the voice that low potassium vegetables were useful for the potassium management of patients was high. Low potassium vegetables are expected to complement potassium management in CKD patients including maintenance hemodialysis patients.

Academic Significance and Societal Importance of the Research Achievements

透析患者さんは、血液のカリウム値が高くなって不整脈や心臓停止を起こすことがあるため、カリウムの管理はとても重要です。生野菜をそのまま食べることができないことから食事の楽しみが制限されています。
近年、水耕栽培によりカリウム量を大幅に少なくした野菜が生産され販売されるようになりました。この研究では、血液透析患者さんにその低カリウム野菜を食べていただき、その前後での印象をお尋ねしました。その結果、生野菜の触感を楽しむことができ、また長く保存できると好意的な意見で、さらなる種類の増加と普及を望んでいました。今後の透析患者さんのカリウム管理に低カリウム野菜は役に立つと期待されます。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (18 results)

All 2019 2018 2017 2016 Other

All Journal Article (15 results) (of which Int'l Joint Research: 3 results,  Open Access: 6 results,  Peer Reviewed: 9 results) Presentation (1 results) (of which Invited: 1 results) Remarks (2 results)

  • [Journal Article] Emergence of Smoldering ANCA-associated Glomerulonephritis during the Clinical Course of Mixed Connective Tissue Disease and Sjögren's Syndrome2018

    • Author(s)
      Morimoto C, Fujigaki Y, Tamura Y, Ota T, Shibata S, Asako K, Kikuchi H, Kono H, Kondo F, Yamaguchi Y, Uchida S.
    • Journal Title

      Internal Medicine

      Volume: 57 Issue: 12 Pages: 1757-1762

    • DOI

      10.2169/internalmedicine.9844-17

    • NAID

      130007397142

    • ISSN
      0918-2918, 1349-7235
    • Year and Date
      2018-06-15
    • Related Report
      2017 Research-status Report
    • Open Access
  • [Journal Article] Association of cholesterol efflux capacity with plasmalogen levels of high-density lipoprotein: A cross-sectional study in chronic kidney disease patients.2018

    • Author(s)
      Maeba R, Kojima KI, Nagura M, Komori A, Nishimukai M, Okazaki T, Uchida S.
    • Journal Title

      Atherosclerosis

      Volume: 270 Pages: 102-109

    • Related Report
      2017 Research-status Report
  • [Journal Article] Uric acid in the follow-up determines 30% decline in estimated GFR over 2 years: A propensity score analysis2017

    • Author(s)
      Chang WX, Xu N, Kumagai T, Iijima R, Waki K, Yamanaka M, Nagura M, Arai S, Tamura Y, Shibata S, Fujigaki Y, Uchida S.
    • Journal Title

      Kidney & blood pressure research

      Volume: 42 Issue: 6 Pages: 1053

    • DOI

      10.1159/000485593

    • NAID

      130005859009

    • Related Report
      2017 Research-status Report
    • Open Access / Int'l Joint Research
  • [Journal Article] Unique proximal tubular cell injury and the development of acute kidney injury in adult patients with minimal change nephrotic syndrome2017

    • Author(s)
      Fujigaki Y, Tamura Y, Nagura M, Arai S, Ota T, Shibata S, Kondo F, Yamaguchi Y, Uchida S.
    • Journal Title

      BMC nephrology

      Volume: 18 Issue: 1 Pages: 339-339

    • DOI

      10.1186/s12882-017-0756-6

    • Related Report
      2017 Research-status Report
    • Open Access
  • [Journal Article] Discontinuation of Hemodialysis in a Patient with Anti-GBM Disease by the Treatment with Corticosteroids and Plasmapheresis despite Several Predictors for Dialysis-Dependence.2017

    • Author(s)
      Fujigaki Y, Morimoto C, Iino R, Taniguchi K, Kawamorita Y, Asakawa S, Toyoki D, Miyano S, Fujii W, Ota T, Shibata S, Uchida S.
    • Journal Title

      Case reports in nephrology

      Volume: 2017 Pages: 7143649-7143649

    • DOI

      10.1155/2017/7143649

    • Related Report
      2017 Research-status Report
  • [Journal Article] Renoprotective effect of topiroxostat via antioxidant activity in puromycin aminonucleoside nephrosis rats2017

    • Author(s)
      Kawamorita Y, Shiraishi T, Tamura Y, Kumagai T, Shibata S, Fujigaki Y, Hosoyamada M, Nakagawa T, Uchida S.
    • Journal Title

      Physiological reports

      Volume: 5 Issue: 15 Pages: e13358-e13358

    • DOI

      10.14814/phy2.13358

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Insulin stimulates uric acid reabsorption via regulating urate transporter 1 and ATP-binding cassette subfamily G member 22017

    • Author(s)
      Toyoki D, Shibata S, Kuribayashi-Okuma E, Xu N, Ishizawa K, Hosoyamada M, Uchida S.
    • Journal Title

      American journal of physiology. Renal physiology.

      Volume: 313 Issue: 3 Pages: 826-834

    • DOI

      10.1152/ajprenal.00012.2017

    • URL

      https://pure.teikyo.jp/en/publications/d06c4a71-34cf-4f10-975e-deddfb7da550

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] A Rare Adult Case with Diffuse Segmental Membranous Glomerulonephritis2017

    • Author(s)
      Fujigaki Y, Tamura Y, Shibata S, Kondo F, Iwakura T, Kojima K, Yamaguchi Y, Uchida S.
    • Journal Title

      Internal Medicine

      Volume: 56 Issue: 13 Pages: 1691-1695

    • DOI

      10.2169/internalmedicine.56.8298

    • NAID

      130006858086

    • ISSN
      0918-2918, 1349-7235
    • Related Report
      2017 Research-status Report
    • Open Access
  • [Journal Article] Immunohistochemical and in situ hybridization study of urate transporters GLUT9/URATv1, ABCG2, and URAT1 in the murine brain.2016

    • Author(s)
      Tomioka NH, Tamura Y, Takada T, Shibata S, Suzuki H, Uchida S, Hosoyamada M.
    • Journal Title

      Fluids Barriers CNS.2016 Dec 12

      Volume: 3(1) Pages: 22-22

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Potassium depletion stimulates Na-Cl cotransporter via phosphorylation and inactivation of the ubiquitin ligase Kelch-like 32016

    • Author(s)
      Kenichi Ishizawa, Ning Xu, Johannes Loffing, Richard P. Lifton, Toshiro Fujita, Shunya Uchida, Shigeru Shibata.
    • Journal Title

      Biochem Biophys Res Commun. 2016 Nov

      Volume: 480 Issue: 4 Pages: 745

    • DOI

      10.1016/j.bbrc.2016.10.127

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Pathological implications of linear immunoglobulin G staining on the glomerular capillary walls in a case of infection-related glomerulonephritis2016

    • Author(s)
      Yoshihide Fujigaki, Yosuke Kawamorita, Hiromi Yamaguchi, Shigeyuki Arai, Yoshifuru Tamura, Tatsuru Ota, Shigeru Shibata, Fukuo Kondo, Yutaka Yamaguchi, Shunya Uchida.
    • Journal Title

      Pathology International Pathol Int. 2016 Sep

      Volume: 66 Issue: 9 Pages: 524

    • DOI

      10.1111/pin.12441

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] The Impact of Normal Range of Serum Phosphorus on the Incidence of End-Stage Renal Disease by A Propensity Score Analysis.2016

    • Author(s)
      Chang W-X, Xu N, Kumagai T, Shiraishi T, Kikuyama T, Omizo H, Sakai K, Arai S, Tamura Y, Ota T, Shibata S, Fujigaki Y, Shen Z-Y, Uchida S.
    • Journal Title

      PLoS ONE. 2016 Apr 28

      Volume: 11(4) Pages: 0154469-0154469

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Uric acid metabolism of kidney and intestine in a rat model of chronic kidney disease.Nucleosides,2016

    • Author(s)
      Nagura, M, Tamura Y, Kumagai T, Hosoyamada M, Uchida S.
    • Journal Title

      Nucleotides and Nucleic Acids, 2016 Dec

      Volume: 35(10-12) Pages: 550-558

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Urat1-Uox double knockout mice are experimental animal models of renal hypouricemia and exercise-induced acute kidney injury. Nucleosides,2016

    • Author(s)
      Hosoyamada M, Tsurumi Y, Hirano H, Tomioka N, Sekine Y, Morisaki T, Uchida S.
    • Journal Title

      Nucleotides and Nucleic Acids, 2016 Dec

      Volume: 35(10-12) Pages: 543-549

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Stimulation of V1a receptor increases renal uric acid clearance via urate transporters: Insight into pathogenesis of hypouricemia in SIADH2016

    • Author(s)
      Taniguchi K, Tamura Y, Kumagai T, Shibata S, Uchida S.
    • Journal Title

      Clin Exp Nephrol. 2016 Dec

      Volume: 20(6) Pages: 845-852

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Presentation] 血液透析患者に対する低カリウム野菜の有用性について~アンケート 調査と臨床試験の結果から2019

    • Author(s)
      内田俊也、奈倉倫人、秋山留美、柴田 茂
    • Organizer
      第4回全国低カリウム野菜フォーラム
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Remarks] 低カリウム野菜フォーラムを開催しました

    • URL

      https://www.teikyo-u.ac.jp/campus_news/itabashi/2019/0417_8191.html

    • Related Report
      2018 Annual Research Report
  • [Remarks] 全国低カリウム野菜研究会

    • URL

      http://teikariyasai.jp/profile/

    • Related Report
      2018 Annual Research Report

URL: 

Published: 2016-04-21   Modified: 2020-03-30  

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