Screening of factors required for uptake of vitamin A into hepatic stellate cells
| Project/Area Number |
16K00872
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Eating habits
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
松浦 知和 東京慈恵会医科大学, 医学部, 教授 (30199749)
岩本 武夫 東京慈恵会医科大学, 医学部, 教授 (90568891)
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| Project Period (FY) |
2016-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | ビタミンA / 肝臓 / 星細胞 / 北極圏 / 放射能 / 遺伝子 / 酵素 / 蛋白質 / 栄養学 / 医療・福祉 |
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| Outline of Final Research Achievements |
Vitamin A is a fat-soluble vitamin required for many physiological functions, however, excess intake of vitamin A causes hypervitaminosis A. Polar bears, the top predators in the Arctic, take a large amount of vitamin A but they do not suffer from hypervitaminosis A. We analyzed vitamin A-esterifying enzyme, LRAT, and revealed that LRAT activities of liver microsome fractions from polar bears were considerably lower than those obtained from rats. LRAT and cellular retinol-binding protein (CRBP) I were well co-localized. The CRBP I effectively conveys retinol to the LRAT, thereby alleviating the low enzymatic activity of LRAT in polar bear livers.
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| Academic Significance and Societal Importance of the Research Achievements |
分厚い脂肪に覆われたアザラシなどを捕食するホッキョクグマは、必然的に高濃度のビタミンAを摂取することになり、ビタミンA過剰症の危機にさらされたが、進化の過程で効率的なビタミンA貯蔵能力を獲得することで、その地位を維持することが可能になったと考えられる。本研究で得られたビタミンA貯蔵に関する知見は、ヒトにおけるビタミンA過剰症や欠乏症の解決にも役立つと思われる。
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Report
(5 results)
Research Products
(21 results)
