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A study of the combined effects of soy isoflavones and indigestible food components for prevention of osteoporosis.

Research Project

Project/Area Number 16K00901
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Eating habits
Research InstitutionNational Institutes of Biomedical Innovation, Health and Nutrition

Principal Investigator

Tousen Yuko  国立研究開発法人医薬基盤・健康・栄養研究所, 国立健康・栄養研究所 食品保健機能研究部, 室長 (20360092)

Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywords閉経後骨粗鬆症 / 大豆イソフラボン / 難消化性食品 / 腸内細菌叢 / エクオール / 骨密度 / 難消化性グルカン / 炎症 / 骨代謝 / 骨粗鬆症 / 腸内細菌 / 閉経後女性 / 難消化性食品成分 / 食物繊維
Outline of Final Research Achievements

In the present study, we demonstrated that the combination of indigestible food components and soy isoflavone might prevent osteoporosis through prebiotic effect. We examined the modulation of microbiota to understand the mechanism underlying the prebiotic effect of this combination on bone metabolism in ovariectomised (OVX) mice. The combination of daidzein and indigestible glucan enhanced the production of equol by modulating the microbiota and mitigated the OVX-induced decline in bone mineral density of mice.

Academic Significance and Societal Importance of the Research Achievements

ダイゼインと難消化性グルカンの併用摂取は、腸内細菌叢の変化を介してエクオール産生を亢進させるとともに、骨密度の低下を防ぐ可能性が示唆された。本研究成果は、プレバイオティクス作用により腸内細菌叢の変化を介して、骨密度低下を防いでいる点が学術的に優れていると考えられる。また、本研究成果は閉経後骨粗鬆症の予防における食生活の重要性を示すものであり、社会的にも意義があると思われる。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (18 results)

All 2019 2018 2017 2016

All Journal Article (7 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 7 results,  Open Access: 4 results) Presentation (10 results) (of which Int'l Joint Research: 3 results,  Invited: 1 results) Book (1 results)

  • [Journal Article] Resistant starch attenuates bone Loss in ovariectomised mice by regulating the intestinal microbiota and bone-marrow inflammation.2019

    • Author(s)
      Tousen Y, Matsumoto Y, Nagahata Y, Kobayashi I, Inoue M, Ishimi Y.
    • Journal Title

      Nutrients.

      Volume: 11(2) Issue: 2 Pages: 297-297

    • DOI

      10.3390/nu11020297

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] β-Carotene prevents bone loss in hind limb unloading mice2018

    • Author(s)
      Matsumoto Yu, Tousen Y and Ishimi Y.
    • Journal Title

      Journal of Clinical Biochemistry and Nutrition

      Volume: 63 Issue: 1 Pages: 42-49

    • DOI

      10.3164/jcbn.17-86

    • NAID

      130007387114

    • ISSN
      0912-0009, 1880-5086
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effect of daidzein and equol on DNA replication in MCF-7 cells2018

    • Author(s)
      Tsuji Mako、Tanaka Tomoki、Nagashima Ryosuke、Sagisaka Yuka、Tousen Yuko、Nishide Yoriko、Ishimi Yoshiko、Ishimi Yukio
    • Journal Title

      Journal of Biochemistry

      Volume: 163 Issue: 5 Pages: 371-380

    • DOI

      10.1093/jb/mvy006

    • NAID

      40021555315

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The effects of green kiwifruit combined with isoflavones on equol production, bone turnover and gut microflora in healthy postmenopausal women.2018

    • Author(s)
      Kruger MC, Middlemiss C, Katsumata S, Tousen Y, Ishimi Y.
    • Journal Title

      Asia Pacific Journal of Clinical Nutrition

      Volume: 27(2) Pages: 347-358

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effects of Siberian Ginseng on Hepatic Drug Metabolizing Enzymes and Bone Mineral Density in Ovariectomized Mice2017

    • Author(s)
      東泉 裕子, 松本 雄宇, 西出 依子,山内 淳,竹林 純,渕野 裕之,河野徳昭,吉松 嘉代,川原 信夫,石見 佳子.
    • Journal Title

      The Japanese Journal of Nutrition and Dietetics

      Volume: 75 Issue: 6 Pages: 151-163

    • DOI

      10.5264/eiyogakuzashi.75.151

    • NAID

      130006313505

    • ISSN
      0021-5147, 1883-7921
    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The combined effects of soya isoflavones and resistant starch on equol production and trabecular bone loss in ovariectomised mice.2016

    • Author(s)
      Tousen Y, Matsumoto Y, Matsumoto C, Nishide Y, Nagahata Y, Kobayashi I, Ishimi Y
    • Journal Title

      Br J Nutr.

      Volume: 116(2) Issue: 2 Pages: 247-57

    • DOI

      10.1017/s0007114516001537

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Combined effects of soy isoflavones and milk basic protein on bone mineral density in hind-limb unloaded mice2016

    • Author(s)
      Matsumoto Y, Tousen Y, Nishide Y, Tadashi M, Kato K, Ishimi Y
    • Journal Title

      Journal of Clinical Biochemistry and Nutrition

      Volume: 58 Issue: 2 Pages: 141-145

    • DOI

      10.3164/jcbn.14-137

    • NAID

      130005132518

    • ISSN
      0912-0009, 1880-5086
    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Presentation] 閉経後モデルマウスにおける葛の花由来イソフラボン抽出物の安全性・有効性評価-大豆イソフラボンとの比較-.2018

    • Author(s)
      東泉裕子、西出依子、竹林純、梅垣敬三、渕野裕之、河野徳昭、乾貴幸、吉松嘉代、川原信夫、石見佳子.
    • Organizer
      第72回日本栄養・食糧学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 骨の健康を維持する機能性宇宙食に関する研究「機能性宇宙食開発の最前線:人類を火星に送るための食材開発」2018

    • Author(s)
      石見佳子、東泉裕子、松本雄宇
    • Organizer
      第72回日本栄養・食糧学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 非荷重モデルマウスの骨密度低下に対するβ-カロテン摂取の影響2018

    • Author(s)
      東泉裕子、松本雄宇、石見佳子
    • Organizer
      第65回日本栄養改善学会学術総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Assessment of safety and efficacy of phytoestrogen, isoflavone, on bone metabolism in animal models.2018

    • Author(s)
      Ishimi Y、Tousen Y.
    • Organizer
      8th Annual World Congress of Molecular & Cell Biology-2018.
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Study on functional space foods focused on bone health.2018

    • Author(s)
      Ishimi Y、Tousen Y.
    • Organizer
      Memorial Symposium for the Establishment of Institute of Space Nutrition of Tokushima University
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] エゾウコギ摂取が閉経後モデルマウスの肝臓薬物代謝酵素および骨密度に及ぼす影響2017

    • Author(s)
      東泉裕子、松本雄宇、西出依子、山内淳、竹林純、渕野裕之、河野徳昭、吉松嘉代、川原信夫、石見佳子
    • Organizer
      第71回日本栄養・食糧学会大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 正常及び閉経後骨粗鬆症モデルマウスにおける甘草抽出物の安全性及び有効性評価2017

    • Author(s)
      東泉裕子、松本雄宇、山内淳、竹林純、渕野裕之、河野徳昭、吉松嘉代、川原信夫、石見佳子
    • Organizer
      第64回日本栄養改善学会学術総会
    • Related Report
      2017 Research-status Report
  • [Presentation] The effects of resistant starch on bone loss via intestinal microbiota and inflammation in ovariectomised mice.2017

    • Author(s)
      Tousen Y、Matsumoto Y、Nagahata Y、Ishimi Y
    • Organizer
      ブエノスアイレス/アルゼンチン(IUNS 21回 国際栄養学会議)
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] レジスタントスターチによる腸内細菌を介した骨代謝調節作用2016

    • Author(s)
      東泉 裕子、松本 雄宇、長畑 雄也、石見 佳子
    • Organizer
      第63回日本栄養改善学会学術総会
    • Place of Presentation
      リンクステーションホール青森(青森県青森市)
    • Related Report
      2016 Research-status Report
  • [Presentation] 腸内細菌を介した難消化性糖質の骨代謝調節作用2016

    • Author(s)
      東泉裕子
    • Organizer
      日本応用糖質科学会東日本支部シンポジウム
    • Place of Presentation
      東京大学(東京都文京区)
    • Related Report
      2016 Research-status Report
    • Invited
  • [Book] 内分泌・糖尿病・代謝内科2017

    • Author(s)
      石見佳子、東泉裕子
    • Total Pages
      4
    • Publisher
      科学評論社
    • Related Report
      2017 Research-status Report

URL: 

Published: 2016-04-21   Modified: 2020-03-30  

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